Mechanism of the Conformational Change of the Protein Methyltransferase SMYD3: A Molecular Dynamics Simulation Study

SMYD3 is a SET-domain-containing methyltransferase that catalyzes the transfer of methyl groups onto lysine residues of substrate proteins. Methylation of MAP3K2 by SMYD3 has been implicated in Ras-driven tumorigenesis, which makes SMYD3 a potential target for cancer therapy. Of all SMYD family prot...

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Detalles Bibliográficos
Autores principales: Sun, Jixue, Li, Zibin, Yang, Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267938/
https://www.ncbi.nlm.nih.gov/pubmed/34281237
http://dx.doi.org/10.3390/ijms22137185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267938/
https://www.ncbi.nlm.nih.gov/pubmed/34281237
http://dx.doi.org/10.3390/ijms22137185

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