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TSH Levels as an Independent Risk Factor for NAFLD and Liver Fibrosis in the General Population
Thyroid hormones may be a risk factor for the development of non-alcoholic fatty liver disease (NAFLD) and its progression to liver fibrosis. The aim of this study is to investigate the relationship between thyroid stimulating hormone (TSH) levels, NAFLD, and liver fibrosis in the general population...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267939/ https://www.ncbi.nlm.nih.gov/pubmed/34209831 http://dx.doi.org/10.3390/jcm10132907 |
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author | Martínez-Escudé, Alba Pera, Guillem Costa-Garrido, Anna Rodríguez, Lluís Arteaga, Ingrid Expósito-Martínez, Carmen Torán-Monserrat, Pere Caballería, Llorenç |
author_facet | Martínez-Escudé, Alba Pera, Guillem Costa-Garrido, Anna Rodríguez, Lluís Arteaga, Ingrid Expósito-Martínez, Carmen Torán-Monserrat, Pere Caballería, Llorenç |
author_sort | Martínez-Escudé, Alba |
collection | PubMed |
description | Thyroid hormones may be a risk factor for the development of non-alcoholic fatty liver disease (NAFLD) and its progression to liver fibrosis. The aim of this study is to investigate the relationship between thyroid stimulating hormone (TSH) levels, NAFLD, and liver fibrosis in the general population. A descriptive cross-sectional study was performed in subjects aged 18–75 years randomly selected from primary care centers between 2012 and 2016. Each subject underwent clinical evaluation, physical examination, blood tests and transient elastography. Descriptive and multivariate logistic regression analyses were used to identify factors associated with NAFLD and fibrosis. We included 2452 subjects (54 ± 12 years; 61% female). Subjects with TSH ≥ 2.5 μIU/mL were significantly associated with obesity, atherogenic dyslipidemia, metabolic syndrome (MetS), hypertransaminasemia and altered cholesterol and triglycerides. The prevalence of NAFLD and liver fibrosis was significantly higher in subjects with TSH ≥ 2.5 (μIU/mL). We found a 1.5 times increased risk of NAFLD, 1.8 and 2.3 times increased risk of liver fibrosis for cut-off points of ≥8.0 kPa and ≥9.2 kPa, respectively, in subjects with TSH ≥ 2.5 μIU/mL compared with TSH < 2.5 μIU/mL (control group), independent of the presence of MetS. These findings remained significant when stratifying TSH, with values ≥ 10 μIU/mL. |
format | Online Article Text |
id | pubmed-8267939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82679392021-07-10 TSH Levels as an Independent Risk Factor for NAFLD and Liver Fibrosis in the General Population Martínez-Escudé, Alba Pera, Guillem Costa-Garrido, Anna Rodríguez, Lluís Arteaga, Ingrid Expósito-Martínez, Carmen Torán-Monserrat, Pere Caballería, Llorenç J Clin Med Article Thyroid hormones may be a risk factor for the development of non-alcoholic fatty liver disease (NAFLD) and its progression to liver fibrosis. The aim of this study is to investigate the relationship between thyroid stimulating hormone (TSH) levels, NAFLD, and liver fibrosis in the general population. A descriptive cross-sectional study was performed in subjects aged 18–75 years randomly selected from primary care centers between 2012 and 2016. Each subject underwent clinical evaluation, physical examination, blood tests and transient elastography. Descriptive and multivariate logistic regression analyses were used to identify factors associated with NAFLD and fibrosis. We included 2452 subjects (54 ± 12 years; 61% female). Subjects with TSH ≥ 2.5 μIU/mL were significantly associated with obesity, atherogenic dyslipidemia, metabolic syndrome (MetS), hypertransaminasemia and altered cholesterol and triglycerides. The prevalence of NAFLD and liver fibrosis was significantly higher in subjects with TSH ≥ 2.5 (μIU/mL). We found a 1.5 times increased risk of NAFLD, 1.8 and 2.3 times increased risk of liver fibrosis for cut-off points of ≥8.0 kPa and ≥9.2 kPa, respectively, in subjects with TSH ≥ 2.5 μIU/mL compared with TSH < 2.5 μIU/mL (control group), independent of the presence of MetS. These findings remained significant when stratifying TSH, with values ≥ 10 μIU/mL. MDPI 2021-06-29 /pmc/articles/PMC8267939/ /pubmed/34209831 http://dx.doi.org/10.3390/jcm10132907 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Martínez-Escudé, Alba Pera, Guillem Costa-Garrido, Anna Rodríguez, Lluís Arteaga, Ingrid Expósito-Martínez, Carmen Torán-Monserrat, Pere Caballería, Llorenç TSH Levels as an Independent Risk Factor for NAFLD and Liver Fibrosis in the General Population |
title | TSH Levels as an Independent Risk Factor for NAFLD and Liver Fibrosis in the General Population |
title_full | TSH Levels as an Independent Risk Factor for NAFLD and Liver Fibrosis in the General Population |
title_fullStr | TSH Levels as an Independent Risk Factor for NAFLD and Liver Fibrosis in the General Population |
title_full_unstemmed | TSH Levels as an Independent Risk Factor for NAFLD and Liver Fibrosis in the General Population |
title_short | TSH Levels as an Independent Risk Factor for NAFLD and Liver Fibrosis in the General Population |
title_sort | tsh levels as an independent risk factor for nafld and liver fibrosis in the general population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267939/ https://www.ncbi.nlm.nih.gov/pubmed/34209831 http://dx.doi.org/10.3390/jcm10132907 |
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