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TSH Levels as an Independent Risk Factor for NAFLD and Liver Fibrosis in the General Population

Thyroid hormones may be a risk factor for the development of non-alcoholic fatty liver disease (NAFLD) and its progression to liver fibrosis. The aim of this study is to investigate the relationship between thyroid stimulating hormone (TSH) levels, NAFLD, and liver fibrosis in the general population...

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Autores principales: Martínez-Escudé, Alba, Pera, Guillem, Costa-Garrido, Anna, Rodríguez, Lluís, Arteaga, Ingrid, Expósito-Martínez, Carmen, Torán-Monserrat, Pere, Caballería, Llorenç
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267939/
https://www.ncbi.nlm.nih.gov/pubmed/34209831
http://dx.doi.org/10.3390/jcm10132907
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author Martínez-Escudé, Alba
Pera, Guillem
Costa-Garrido, Anna
Rodríguez, Lluís
Arteaga, Ingrid
Expósito-Martínez, Carmen
Torán-Monserrat, Pere
Caballería, Llorenç
author_facet Martínez-Escudé, Alba
Pera, Guillem
Costa-Garrido, Anna
Rodríguez, Lluís
Arteaga, Ingrid
Expósito-Martínez, Carmen
Torán-Monserrat, Pere
Caballería, Llorenç
author_sort Martínez-Escudé, Alba
collection PubMed
description Thyroid hormones may be a risk factor for the development of non-alcoholic fatty liver disease (NAFLD) and its progression to liver fibrosis. The aim of this study is to investigate the relationship between thyroid stimulating hormone (TSH) levels, NAFLD, and liver fibrosis in the general population. A descriptive cross-sectional study was performed in subjects aged 18–75 years randomly selected from primary care centers between 2012 and 2016. Each subject underwent clinical evaluation, physical examination, blood tests and transient elastography. Descriptive and multivariate logistic regression analyses were used to identify factors associated with NAFLD and fibrosis. We included 2452 subjects (54 ± 12 years; 61% female). Subjects with TSH ≥ 2.5 μIU/mL were significantly associated with obesity, atherogenic dyslipidemia, metabolic syndrome (MetS), hypertransaminasemia and altered cholesterol and triglycerides. The prevalence of NAFLD and liver fibrosis was significantly higher in subjects with TSH ≥ 2.5 (μIU/mL). We found a 1.5 times increased risk of NAFLD, 1.8 and 2.3 times increased risk of liver fibrosis for cut-off points of ≥8.0 kPa and ≥9.2 kPa, respectively, in subjects with TSH ≥ 2.5 μIU/mL compared with TSH < 2.5 μIU/mL (control group), independent of the presence of MetS. These findings remained significant when stratifying TSH, with values ≥ 10 μIU/mL.
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spelling pubmed-82679392021-07-10 TSH Levels as an Independent Risk Factor for NAFLD and Liver Fibrosis in the General Population Martínez-Escudé, Alba Pera, Guillem Costa-Garrido, Anna Rodríguez, Lluís Arteaga, Ingrid Expósito-Martínez, Carmen Torán-Monserrat, Pere Caballería, Llorenç J Clin Med Article Thyroid hormones may be a risk factor for the development of non-alcoholic fatty liver disease (NAFLD) and its progression to liver fibrosis. The aim of this study is to investigate the relationship between thyroid stimulating hormone (TSH) levels, NAFLD, and liver fibrosis in the general population. A descriptive cross-sectional study was performed in subjects aged 18–75 years randomly selected from primary care centers between 2012 and 2016. Each subject underwent clinical evaluation, physical examination, blood tests and transient elastography. Descriptive and multivariate logistic regression analyses were used to identify factors associated with NAFLD and fibrosis. We included 2452 subjects (54 ± 12 years; 61% female). Subjects with TSH ≥ 2.5 μIU/mL were significantly associated with obesity, atherogenic dyslipidemia, metabolic syndrome (MetS), hypertransaminasemia and altered cholesterol and triglycerides. The prevalence of NAFLD and liver fibrosis was significantly higher in subjects with TSH ≥ 2.5 (μIU/mL). We found a 1.5 times increased risk of NAFLD, 1.8 and 2.3 times increased risk of liver fibrosis for cut-off points of ≥8.0 kPa and ≥9.2 kPa, respectively, in subjects with TSH ≥ 2.5 μIU/mL compared with TSH < 2.5 μIU/mL (control group), independent of the presence of MetS. These findings remained significant when stratifying TSH, with values ≥ 10 μIU/mL. MDPI 2021-06-29 /pmc/articles/PMC8267939/ /pubmed/34209831 http://dx.doi.org/10.3390/jcm10132907 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Martínez-Escudé, Alba
Pera, Guillem
Costa-Garrido, Anna
Rodríguez, Lluís
Arteaga, Ingrid
Expósito-Martínez, Carmen
Torán-Monserrat, Pere
Caballería, Llorenç
TSH Levels as an Independent Risk Factor for NAFLD and Liver Fibrosis in the General Population
title TSH Levels as an Independent Risk Factor for NAFLD and Liver Fibrosis in the General Population
title_full TSH Levels as an Independent Risk Factor for NAFLD and Liver Fibrosis in the General Population
title_fullStr TSH Levels as an Independent Risk Factor for NAFLD and Liver Fibrosis in the General Population
title_full_unstemmed TSH Levels as an Independent Risk Factor for NAFLD and Liver Fibrosis in the General Population
title_short TSH Levels as an Independent Risk Factor for NAFLD and Liver Fibrosis in the General Population
title_sort tsh levels as an independent risk factor for nafld and liver fibrosis in the general population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267939/
https://www.ncbi.nlm.nih.gov/pubmed/34209831
http://dx.doi.org/10.3390/jcm10132907
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