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Immune Circuits to Shape Natural Killer Cells in Cancer
SIMPLE SUMMARY: Natural killer (NK) cells are circulating innate lymphocytes endowed with antitumoral functions. NK cells are the innate counterpart of effector T cells and among the first cells responding to infections and tumors. In this review, the immune circuits regulating the NK cell antitumor...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267947/ https://www.ncbi.nlm.nih.gov/pubmed/34203391 http://dx.doi.org/10.3390/cancers13133225 |
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author | Mattiola, Irene |
author_facet | Mattiola, Irene |
author_sort | Mattiola, Irene |
collection | PubMed |
description | SIMPLE SUMMARY: Natural killer (NK) cells are circulating innate lymphocytes endowed with antitumoral functions. NK cells are the innate counterpart of effector T cells and among the first cells responding to infections and tumors. In this review, the immune circuits regulating the NK cell antitumoral functions and the possible strategies to shape natural killing in cancer will be discussed. ABSTRACT: Natural killer (NK) cells are innate lymphoid cells playing an important role in anti-cancer immunity. NK cells are efficient in controlling the spreading of metastasis but are not very powerful in fighting against primary tumors. The NK cell capability to infiltrate and persist in the tumor microenvironment and to exert their antitumoral functions is often limited by tumor escape mechanisms. These tumor-mediated strategies not only induce NK cell tolerance but also interfere with the NK cell-dependent immune networking. This review will provide an overview of the tumor escape mechanisms impacting NK cells, identify the immune circuits regulating the NK cell-dependent antitumor immunity and revise the emerging therapeutic approaches to unleash NK cells in cancer. |
format | Online Article Text |
id | pubmed-8267947 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82679472021-07-10 Immune Circuits to Shape Natural Killer Cells in Cancer Mattiola, Irene Cancers (Basel) Review SIMPLE SUMMARY: Natural killer (NK) cells are circulating innate lymphocytes endowed with antitumoral functions. NK cells are the innate counterpart of effector T cells and among the first cells responding to infections and tumors. In this review, the immune circuits regulating the NK cell antitumoral functions and the possible strategies to shape natural killing in cancer will be discussed. ABSTRACT: Natural killer (NK) cells are innate lymphoid cells playing an important role in anti-cancer immunity. NK cells are efficient in controlling the spreading of metastasis but are not very powerful in fighting against primary tumors. The NK cell capability to infiltrate and persist in the tumor microenvironment and to exert their antitumoral functions is often limited by tumor escape mechanisms. These tumor-mediated strategies not only induce NK cell tolerance but also interfere with the NK cell-dependent immune networking. This review will provide an overview of the tumor escape mechanisms impacting NK cells, identify the immune circuits regulating the NK cell-dependent antitumor immunity and revise the emerging therapeutic approaches to unleash NK cells in cancer. MDPI 2021-06-28 /pmc/articles/PMC8267947/ /pubmed/34203391 http://dx.doi.org/10.3390/cancers13133225 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mattiola, Irene Immune Circuits to Shape Natural Killer Cells in Cancer |
title | Immune Circuits to Shape Natural Killer Cells in Cancer |
title_full | Immune Circuits to Shape Natural Killer Cells in Cancer |
title_fullStr | Immune Circuits to Shape Natural Killer Cells in Cancer |
title_full_unstemmed | Immune Circuits to Shape Natural Killer Cells in Cancer |
title_short | Immune Circuits to Shape Natural Killer Cells in Cancer |
title_sort | immune circuits to shape natural killer cells in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267947/ https://www.ncbi.nlm.nih.gov/pubmed/34203391 http://dx.doi.org/10.3390/cancers13133225 |
work_keys_str_mv | AT mattiolairene immunecircuitstoshapenaturalkillercellsincancer |