TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer

TENT4A (PAPD7) is a non-canonical poly(A) polymerase, of which little is known. Here, we show that TENT4A regulates multiple biological pathways and focuses on its multilayer regulation of translesion DNA synthesis (TLS), in which error-prone DNA polymerases bypass unrepaired DNA lesions. We show th...

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Detalles Bibliográficos
Autores principales: Swain, Umakanta, Friedlander, Gilgi, Sehrawat, Urmila, Sarusi-Portuguez, Avital, Rotkopf, Ron, Ebert, Charlotte, Paz-Elizur, Tamar, Dikstein, Rivka, Carell, Thomas, Geacintov, Nicholas E., Livneh, Zvi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267958/
https://www.ncbi.nlm.nih.gov/pubmed/34203408
http://dx.doi.org/10.3390/ijms22136957

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