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The Role of Conventional and Stereotactic Microwave Ablation for Intrahepatic Cholangiocarcinoma

Background: The incidence and mortality of intrahepatic cholangiocarcinoma (ICCA) is increasing worldwide and curative treatment options are limited due to the aggressive tumor biology and often late diagnosis. Resection of the primary tumor remains the only curative therapy available, as the benefi...

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Autores principales: Kim-Fuchs, Corina, Candinas, Daniel, Lachenmayer, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268028/
https://www.ncbi.nlm.nih.gov/pubmed/34279447
http://dx.doi.org/10.3390/jcm10132963
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author Kim-Fuchs, Corina
Candinas, Daniel
Lachenmayer, Anja
author_facet Kim-Fuchs, Corina
Candinas, Daniel
Lachenmayer, Anja
author_sort Kim-Fuchs, Corina
collection PubMed
description Background: The incidence and mortality of intrahepatic cholangiocarcinoma (ICCA) is increasing worldwide and curative treatment options are limited due to the aggressive tumor biology and often late diagnosis. Resection of the primary tumor remains the only curative therapy available, as the benefit of palliative chemotherapy and radiotherapy is relatively small. In contrast to hepatocellular carcinoma, minimal-invasive thermal tumor ablation, and in particular stereotactic tumor ablation for small primary cancers or metastases, is not established and data are scarce. Methods: We conducted a literature review in the field of ICCA ablation and retrospective analysis of 10 patients treated by stereotactic microwave ablation (SMWA) for either primary ICCA or liver metastases of ICCA. Results: While current guidelines have no consensus for ablation of primary ICCA, some state that it might be an option in inoperable patients or those with recurrent disease. The literature review revealed 11 studies on microwave ablation for ICCA reporting that MWA for ICCA ≤ 5 cm might be safe and could be a treatment option for patients who are not candidates for surgery. No data has been published on stereotactic microwave ablation (SMWA) for ICCA. The analyses of our own data of 10 patients treated by SMWA for primary ICCA (n = 5) or recurrent ICCA (n = 5) show that the treatment is safe and efficient with short hospital stays and low complication rates. Conclusion: Although thermal ablation, and in particular SMWA, might be a minimally invasive and tissue-sparing curative treatment alternative for small ICCA in the diseased liver and ICCA metastases, the oncologic benefit still needs to be shown in larger studies with longer follow-up.
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spelling pubmed-82680282021-07-10 The Role of Conventional and Stereotactic Microwave Ablation for Intrahepatic Cholangiocarcinoma Kim-Fuchs, Corina Candinas, Daniel Lachenmayer, Anja J Clin Med Article Background: The incidence and mortality of intrahepatic cholangiocarcinoma (ICCA) is increasing worldwide and curative treatment options are limited due to the aggressive tumor biology and often late diagnosis. Resection of the primary tumor remains the only curative therapy available, as the benefit of palliative chemotherapy and radiotherapy is relatively small. In contrast to hepatocellular carcinoma, minimal-invasive thermal tumor ablation, and in particular stereotactic tumor ablation for small primary cancers or metastases, is not established and data are scarce. Methods: We conducted a literature review in the field of ICCA ablation and retrospective analysis of 10 patients treated by stereotactic microwave ablation (SMWA) for either primary ICCA or liver metastases of ICCA. Results: While current guidelines have no consensus for ablation of primary ICCA, some state that it might be an option in inoperable patients or those with recurrent disease. The literature review revealed 11 studies on microwave ablation for ICCA reporting that MWA for ICCA ≤ 5 cm might be safe and could be a treatment option for patients who are not candidates for surgery. No data has been published on stereotactic microwave ablation (SMWA) for ICCA. The analyses of our own data of 10 patients treated by SMWA for primary ICCA (n = 5) or recurrent ICCA (n = 5) show that the treatment is safe and efficient with short hospital stays and low complication rates. Conclusion: Although thermal ablation, and in particular SMWA, might be a minimally invasive and tissue-sparing curative treatment alternative for small ICCA in the diseased liver and ICCA metastases, the oncologic benefit still needs to be shown in larger studies with longer follow-up. MDPI 2021-07-01 /pmc/articles/PMC8268028/ /pubmed/34279447 http://dx.doi.org/10.3390/jcm10132963 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim-Fuchs, Corina
Candinas, Daniel
Lachenmayer, Anja
The Role of Conventional and Stereotactic Microwave Ablation for Intrahepatic Cholangiocarcinoma
title The Role of Conventional and Stereotactic Microwave Ablation for Intrahepatic Cholangiocarcinoma
title_full The Role of Conventional and Stereotactic Microwave Ablation for Intrahepatic Cholangiocarcinoma
title_fullStr The Role of Conventional and Stereotactic Microwave Ablation for Intrahepatic Cholangiocarcinoma
title_full_unstemmed The Role of Conventional and Stereotactic Microwave Ablation for Intrahepatic Cholangiocarcinoma
title_short The Role of Conventional and Stereotactic Microwave Ablation for Intrahepatic Cholangiocarcinoma
title_sort role of conventional and stereotactic microwave ablation for intrahepatic cholangiocarcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268028/
https://www.ncbi.nlm.nih.gov/pubmed/34279447
http://dx.doi.org/10.3390/jcm10132963
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