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Iron Chelator Induces Apoptosis in Osteosarcoma Cells by Disrupting Intracellular Iron Homeostasis and Activating the MAPK Pathway

Osteosarcoma is a common malignant bone tumor in clinical orthopedics. Iron chelators have inhibitory effects on many cancers, but their effects and mechanisms in osteosarcoma are still uncertain. Our in vitro results show that deferoxamine (DFO) and deferasirox (DFX), two iron chelators, significan...

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Detalles Bibliográficos
Autores principales:	Xue, Yanru, Zhang, Gejing, Zhou, Shoujie, Wang, Shenghang, Lv, Huanhuan, Zhou, Liangfu, Shang, Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268062/ https://www.ncbi.nlm.nih.gov/pubmed/34281233 http://dx.doi.org/10.3390/ijms22137168

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