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Brain Mechanisms of COVID-19-Sleep Disorders

2020 and 2021 have been unprecedented years due to the rapid spread of the modified severe acute respiratory syndrome coronavirus around the world. The coronavirus disease 2019 (COVID-19) causes atypical infiltrated pneumonia with many neurological symptoms, and major sleep changes. The exposure of...

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Autores principales: Semyachkina-Glushkovskaya, Oxana, Mamedova, Aysel, Vinnik, Valeria, Klimova, Maria, Saranceva, Elena, Ageev, Vasily, Yu, Tingting, Zhu, Dan, Penzel, Thomas, Kurths, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268116/
https://www.ncbi.nlm.nih.gov/pubmed/34203143
http://dx.doi.org/10.3390/ijms22136917
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author Semyachkina-Glushkovskaya, Oxana
Mamedova, Aysel
Vinnik, Valeria
Klimova, Maria
Saranceva, Elena
Ageev, Vasily
Yu, Tingting
Zhu, Dan
Penzel, Thomas
Kurths, Jürgen
author_facet Semyachkina-Glushkovskaya, Oxana
Mamedova, Aysel
Vinnik, Valeria
Klimova, Maria
Saranceva, Elena
Ageev, Vasily
Yu, Tingting
Zhu, Dan
Penzel, Thomas
Kurths, Jürgen
author_sort Semyachkina-Glushkovskaya, Oxana
collection PubMed
description 2020 and 2021 have been unprecedented years due to the rapid spread of the modified severe acute respiratory syndrome coronavirus around the world. The coronavirus disease 2019 (COVID-19) causes atypical infiltrated pneumonia with many neurological symptoms, and major sleep changes. The exposure of people to stress, such as social confinement and changes in daily routines, is accompanied by various sleep disturbances, known as ‘coronasomnia’ phenomenon. Sleep disorders induce neuroinflammation, which promotes the blood–brain barrier (BBB) disruption and entry of antigens and inflammatory factors into the brain. Here, we review findings and trends in sleep research in 2020–2021, demonstrating how COVID-19 and sleep disorders can induce BBB leakage via neuroinflammation, which might contribute to the ‘coronasomnia’ phenomenon. The new studies suggest that the control of sleep hygiene and quality should be incorporated into the rehabilitation of COVID-19 patients. We also discuss perspective strategies for the prevention of COVID-19-related BBB disorders. We demonstrate that sleep might be a novel biomarker of BBB leakage, and the analysis of sleep EEG patterns can be a breakthrough non-invasive technology for diagnosis of the COVID-19-caused BBB disruption.
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spelling pubmed-82681162021-07-10 Brain Mechanisms of COVID-19-Sleep Disorders Semyachkina-Glushkovskaya, Oxana Mamedova, Aysel Vinnik, Valeria Klimova, Maria Saranceva, Elena Ageev, Vasily Yu, Tingting Zhu, Dan Penzel, Thomas Kurths, Jürgen Int J Mol Sci Review 2020 and 2021 have been unprecedented years due to the rapid spread of the modified severe acute respiratory syndrome coronavirus around the world. The coronavirus disease 2019 (COVID-19) causes atypical infiltrated pneumonia with many neurological symptoms, and major sleep changes. The exposure of people to stress, such as social confinement and changes in daily routines, is accompanied by various sleep disturbances, known as ‘coronasomnia’ phenomenon. Sleep disorders induce neuroinflammation, which promotes the blood–brain barrier (BBB) disruption and entry of antigens and inflammatory factors into the brain. Here, we review findings and trends in sleep research in 2020–2021, demonstrating how COVID-19 and sleep disorders can induce BBB leakage via neuroinflammation, which might contribute to the ‘coronasomnia’ phenomenon. The new studies suggest that the control of sleep hygiene and quality should be incorporated into the rehabilitation of COVID-19 patients. We also discuss perspective strategies for the prevention of COVID-19-related BBB disorders. We demonstrate that sleep might be a novel biomarker of BBB leakage, and the analysis of sleep EEG patterns can be a breakthrough non-invasive technology for diagnosis of the COVID-19-caused BBB disruption. MDPI 2021-06-28 /pmc/articles/PMC8268116/ /pubmed/34203143 http://dx.doi.org/10.3390/ijms22136917 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Semyachkina-Glushkovskaya, Oxana
Mamedova, Aysel
Vinnik, Valeria
Klimova, Maria
Saranceva, Elena
Ageev, Vasily
Yu, Tingting
Zhu, Dan
Penzel, Thomas
Kurths, Jürgen
Brain Mechanisms of COVID-19-Sleep Disorders
title Brain Mechanisms of COVID-19-Sleep Disorders
title_full Brain Mechanisms of COVID-19-Sleep Disorders
title_fullStr Brain Mechanisms of COVID-19-Sleep Disorders
title_full_unstemmed Brain Mechanisms of COVID-19-Sleep Disorders
title_short Brain Mechanisms of COVID-19-Sleep Disorders
title_sort brain mechanisms of covid-19-sleep disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268116/
https://www.ncbi.nlm.nih.gov/pubmed/34203143
http://dx.doi.org/10.3390/ijms22136917
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