Cargando…

A conditional multi-trait sequence GWAS discovers pleiotropic candidate genes and variants for sheep wool, skin wrinkle and breech cover traits

BACKGROUND: Imputation to whole-genome sequence is now possible in large sheep populations. It is therefore of interest to use this data in genome-wide association studies (GWAS) to investigate putative causal variants and genes that underpin economically important traits. Merino wool is globally so...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bolormaa, Sunduimijid, Swan, Andrew A., Stothard, Paul, Khansefid, Majid, Moghaddar, Nasir, Duijvesteijn, Naomi, van der Werf, Julius H. J., Daetwyler, Hans D., MacLeod, Iona M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268212/ https://www.ncbi.nlm.nih.gov/pubmed/34238208 http://dx.doi.org/10.1186/s12711-021-00651-0

Ejemplares similares

Multiple-trait QTL mapping and genomic prediction for wool traits in sheep
por: Bolormaa, Sunduimijid, et al.
Publicado: (2017)

Genomic prediction based on selected variants from imputed whole-genome sequence data in Australian sheep populations
por: Moghaddar, Nasir, et al.
Publicado: (2019)

Accuracy of imputation to whole-genome sequence in sheep
por: Bolormaa, Sunduimijid, et al.
Publicado: (2019)

Genome-wide comparative analyses of correlated and uncorrelated phenotypes identify major pleiotropic variants in dairy cattle
por: Xiang, Ruidong, et al.
Publicado: (2017)

Genomic prediction of the polled and horned phenotypes in Merino sheep
por: Duijvesteijn, Naomi, et al.
Publicado: (2018)

Detailed phenotyping identifies genes with pleiotropic effects on body composition
por: Bolormaa, Sunduimijid, et al.
Publicado: (2016)

Expression quantitative trait loci in sheep liver and muscle contribute to variations in meat traits
por: Yuan, Zehu, et al.
Publicado: (2021)

Using imputed whole-genome sequence data to improve the accuracy of genomic prediction for parasite resistance in Australian sheep
por: Al Kalaldeh, Mohammad, et al.
Publicado: (2019)

Genome-wide fine-mapping identifies pleiotropic and functional variants that predict many traits across global cattle populations
por: Xiang, Ruidong, et al.
Publicado: (2021)

Comparing allele specific expression and local expression quantitative trait loci and the influence of gene expression on complex trait variation in cattle
por: Khansefid, Majid, et al.
Publicado: (2018)

Accuracy of Genomic Prediction for Milk Production Traits in Philippine Dairy Buffaloes
por: Herrera, Jesus Rommel V., et al.
Publicado: (2021)

Mutant alleles differentially shape fitness and other complex traits in cattle
por: Xiang, Ruidong, et al.
Publicado: (2021)

A Multi-Trait, Meta-analysis for Detecting Pleiotropic Polymorphisms for Stature, Fatness and Reproduction in Beef Cattle
por: Bolormaa, Sunduimijid, et al.
Publicado: (2014)

Eating Time as a Genetic Indicator of Methane Emissions and Feed Efficiency in Australian Maternal Composite Sheep
por: Sepulveda, Boris J., et al.
Publicado: (2022)

Quantifying the contribution of sequence variants with regulatory and evolutionary significance to 34 bovine complex traits
por: Xiang, Ruidong, et al.
Publicado: (2019)

GWAS hints at pleiotropic roles for FLOWERING LOCUS T in flowering time and yield-related traits in canola
por: Raman, Harsh, et al.
Publicado: (2019)

Pleiotropic Effects of Trait-Associated Genetic Variation on DNA Methylation: Utility for Refining GWAS Loci
por: Hannon, Eilis, et al.
Publicado: (2017)

Effect direction meta-analysis of GWAS identifies extreme, prevalent and shared pleiotropy in a large mammal
por: Xiang, Ruidong, et al.
Publicado: (2020)

Meta‐analysis of genetic parameters for growth traits in meat, wool and dual‐purpose sheep breeds in the world using a random‐effects model
por: Abasi‐Mousa, Sara, et al.
Publicado: (2022)

Regulatory and coding genome regions are enriched for trait associated variants in dairy and beef cattle
por: Koufariotis, Lambros, et al.
Publicado: (2014)

Selection for complex traits leaves little or no classic signatures of selection
por: Kemper, Kathryn E, et al.
Publicado: (2014)

Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits
por: Bone, William P., et al.
Publicado: (2021)

Sharing of either phenotypes or genetic variants can increase the accuracy of genomic prediction of feed efficiency
por: Bolormaa, Sunduimijid, et al.
Publicado: (2022)

Whole-genome re-sequencing association study on yearling wool traits in Chinese fine-wool sheep
por: Zhao, Hongchang, et al.
Publicado: (2021)

Non-additive genetic variation in growth, carcass and fertility traits of beef cattle
por: Bolormaa, Sunduimijid, et al.
Publicado: (2015)

Discovering of Genomic Variations Associated to Growth Traits by GWAS in Braunvieh Cattle
por: Zepeda-Batista, José Luis, et al.
Publicado: (2021)

Leveraging pleiotropy to discover and interpret GWAS results for sleep-associated traits
por: Chun, Sung, et al.
Publicado: (2022)

Genome-Wide Scan of Wool Production Traits in Akkaraman Sheep
por: Arzik, Yunus, et al.
Publicado: (2023)

Rare Variants in Transcript and Potential Regulatory Regions Explain a Small Percentage of the Missing Heritability of Complex Traits in Cattle
por: Gonzalez-Recio, Oscar, et al.
Publicado: (2015)

Multi-breed genomic prediction using Bayes R with sequence data and dropping variants with a small effect
por: van den Berg, Irene, et al.
Publicado: (2017)

Accuracy of pedigree and genomic predictions of carcass and novel meat quality traits in multi-breed sheep data assessed by cross-validation
por: Daetwyler, Hans D, et al.
Publicado: (2012)

Genome variants associated with RNA splicing variations in bovine are extensively shared between tissues
por: Xiang, Ruidong, et al.
Publicado: (2018)

GWAS for the composite traits of hematuria and albuminuria
por: Gagliano Taliun, Sarah A., et al.
Publicado: (2023)

Genome-wide association studies detects candidate genes for wool traits by re-sequencing in Chinese fine-wool sheep
por: Zhao, Hongchang, et al.
Publicado: (2021)

Trait selection strategy in multi-trait GWAS: Boosting SNPs discoverability
por: Suzuki, Yuka, et al.
Publicado: (2023)

Association analysis of polymorphisms in six keratin genes with wool traits in sheep
por: Sulayman, Ablat, et al.
Publicado: (2018)

Complex trait architecture: the pleiotropic model revisited
por: North, T.-L., et al.
Publicado: (2015)

A scalable variational approach to characterize pleiotropic components across thousands of human diseases and complex traits using GWAS summary statistics
por: Zhang, Zixuan, et al.
Publicado: (2023)

BayesR3 enables fast MCMC blocked processing for largescale multi-trait genomic prediction and QTN mapping analysis
por: Breen, Edmond J., et al.
Publicado: (2022)

Polymorphisms of FST gene and their association with wool quality traits in Chinese Merino sheep
por: Ma, Guang-Wei, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_abrj7ds1fbq4fpjko8r87aloh5