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Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19
The gut microbiota is well known to exert multiple benefits on human health including protection from disease causing pathobiont microbes. It has been recognized that healthy intestinal microbiota is of great importance in the pathogenesis of COVID-19. Gut dysbiosis caused by various reasons is asso...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268324/ https://www.ncbi.nlm.nih.gov/pubmed/34209870 http://dx.doi.org/10.3390/jcm10132903 |
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author | Chen, Jiezhong Vitetta, Luis |
author_facet | Chen, Jiezhong Vitetta, Luis |
author_sort | Chen, Jiezhong |
collection | PubMed |
description | The gut microbiota is well known to exert multiple benefits on human health including protection from disease causing pathobiont microbes. It has been recognized that healthy intestinal microbiota is of great importance in the pathogenesis of COVID-19. Gut dysbiosis caused by various reasons is associated with severe COVID-19. Therefore, the modulation of gut microbiota and supplementation of commensal bacterial metabolites could reduce the severity of COVID-19. Many approaches have been studied to improve gut microbiota in COVID-19 including probiotics, bacterial metabolites, and prebiotics, as well as nutraceuticals and trace elements. So far, 19 clinical trials for testing the efficacy of probiotics and synbiotics in COVID-19 prevention and treatment are ongoing. In this narrative review, we summarize the effects of various approaches on the prevention and treatment of COVID-19 and discuss associated mechanisms. |
format | Online Article Text |
id | pubmed-8268324 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82683242021-07-10 Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19 Chen, Jiezhong Vitetta, Luis J Clin Med Review The gut microbiota is well known to exert multiple benefits on human health including protection from disease causing pathobiont microbes. It has been recognized that healthy intestinal microbiota is of great importance in the pathogenesis of COVID-19. Gut dysbiosis caused by various reasons is associated with severe COVID-19. Therefore, the modulation of gut microbiota and supplementation of commensal bacterial metabolites could reduce the severity of COVID-19. Many approaches have been studied to improve gut microbiota in COVID-19 including probiotics, bacterial metabolites, and prebiotics, as well as nutraceuticals and trace elements. So far, 19 clinical trials for testing the efficacy of probiotics and synbiotics in COVID-19 prevention and treatment are ongoing. In this narrative review, we summarize the effects of various approaches on the prevention and treatment of COVID-19 and discuss associated mechanisms. MDPI 2021-06-29 /pmc/articles/PMC8268324/ /pubmed/34209870 http://dx.doi.org/10.3390/jcm10132903 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chen, Jiezhong Vitetta, Luis Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19 |
title | Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19 |
title_full | Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19 |
title_fullStr | Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19 |
title_full_unstemmed | Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19 |
title_short | Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19 |
title_sort | modulation of gut microbiota for the prevention and treatment of covid-19 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268324/ https://www.ncbi.nlm.nih.gov/pubmed/34209870 http://dx.doi.org/10.3390/jcm10132903 |
work_keys_str_mv | AT chenjiezhong modulationofgutmicrobiotaforthepreventionandtreatmentofcovid19 AT vitettaluis modulationofgutmicrobiotaforthepreventionandtreatmentofcovid19 |