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Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19

The gut microbiota is well known to exert multiple benefits on human health including protection from disease causing pathobiont microbes. It has been recognized that healthy intestinal microbiota is of great importance in the pathogenesis of COVID-19. Gut dysbiosis caused by various reasons is asso...

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Autores principales: Chen, Jiezhong, Vitetta, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268324/
https://www.ncbi.nlm.nih.gov/pubmed/34209870
http://dx.doi.org/10.3390/jcm10132903
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author Chen, Jiezhong
Vitetta, Luis
author_facet Chen, Jiezhong
Vitetta, Luis
author_sort Chen, Jiezhong
collection PubMed
description The gut microbiota is well known to exert multiple benefits on human health including protection from disease causing pathobiont microbes. It has been recognized that healthy intestinal microbiota is of great importance in the pathogenesis of COVID-19. Gut dysbiosis caused by various reasons is associated with severe COVID-19. Therefore, the modulation of gut microbiota and supplementation of commensal bacterial metabolites could reduce the severity of COVID-19. Many approaches have been studied to improve gut microbiota in COVID-19 including probiotics, bacterial metabolites, and prebiotics, as well as nutraceuticals and trace elements. So far, 19 clinical trials for testing the efficacy of probiotics and synbiotics in COVID-19 prevention and treatment are ongoing. In this narrative review, we summarize the effects of various approaches on the prevention and treatment of COVID-19 and discuss associated mechanisms.
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spelling pubmed-82683242021-07-10 Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19 Chen, Jiezhong Vitetta, Luis J Clin Med Review The gut microbiota is well known to exert multiple benefits on human health including protection from disease causing pathobiont microbes. It has been recognized that healthy intestinal microbiota is of great importance in the pathogenesis of COVID-19. Gut dysbiosis caused by various reasons is associated with severe COVID-19. Therefore, the modulation of gut microbiota and supplementation of commensal bacterial metabolites could reduce the severity of COVID-19. Many approaches have been studied to improve gut microbiota in COVID-19 including probiotics, bacterial metabolites, and prebiotics, as well as nutraceuticals and trace elements. So far, 19 clinical trials for testing the efficacy of probiotics and synbiotics in COVID-19 prevention and treatment are ongoing. In this narrative review, we summarize the effects of various approaches on the prevention and treatment of COVID-19 and discuss associated mechanisms. MDPI 2021-06-29 /pmc/articles/PMC8268324/ /pubmed/34209870 http://dx.doi.org/10.3390/jcm10132903 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Jiezhong
Vitetta, Luis
Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19
title Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19
title_full Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19
title_fullStr Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19
title_full_unstemmed Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19
title_short Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19
title_sort modulation of gut microbiota for the prevention and treatment of covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268324/
https://www.ncbi.nlm.nih.gov/pubmed/34209870
http://dx.doi.org/10.3390/jcm10132903
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