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Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer
Prognosis of gastric cancer is dramatically improved by early diagnosis. Correa’s cascade correlates the expression of some molecular markers with the progression of preneoplastic lesions toward carcinoma. This article reviews the diagnostic and prognostic values of molecular markers in complete (MU...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268370/ https://www.ncbi.nlm.nih.gov/pubmed/34206291 http://dx.doi.org/10.3390/ijms22136652 |
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author | Battista, Serena Ambrosio, Maria Raffaella Limarzi, Francesco Gallo, Graziana Saragoni, Luca |
author_facet | Battista, Serena Ambrosio, Maria Raffaella Limarzi, Francesco Gallo, Graziana Saragoni, Luca |
author_sort | Battista, Serena |
collection | PubMed |
description | Prognosis of gastric cancer is dramatically improved by early diagnosis. Correa’s cascade correlates the expression of some molecular markers with the progression of preneoplastic lesions toward carcinoma. This article reviews the diagnostic and prognostic values of molecular markers in complete (MUC2) and incomplete (MUC2, MUC5AC, and MUC6) intestinal metaplasia, gastric dysplasia/intra-epithelial neoplasia, and early gastric cancer. In particular, considering preinvasive neoplasia and early gastric cancer, some studies have demonstrated a correlation between molecular alterations and prognosis, for example, mucins phenotype in gastric dysplasia, and GATA6, TP53 mutation/LOH and MUC6 in early gastric cancer. Moreover, this review considers novelties from the literature regarding the (immuno)histochemical characterization of diffuse-type/signet ring cell gastric cancer, with particular attention to clinical outcomes of patients. The aim of this review is the evaluation of the state of the art regarding suitable biomarkers used in the pre-surgical phase, which can distinguish patients with different prognoses and help decide the best therapeutic strategy. |
format | Online Article Text |
id | pubmed-8268370 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82683702021-07-10 Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer Battista, Serena Ambrosio, Maria Raffaella Limarzi, Francesco Gallo, Graziana Saragoni, Luca Int J Mol Sci Review Prognosis of gastric cancer is dramatically improved by early diagnosis. Correa’s cascade correlates the expression of some molecular markers with the progression of preneoplastic lesions toward carcinoma. This article reviews the diagnostic and prognostic values of molecular markers in complete (MUC2) and incomplete (MUC2, MUC5AC, and MUC6) intestinal metaplasia, gastric dysplasia/intra-epithelial neoplasia, and early gastric cancer. In particular, considering preinvasive neoplasia and early gastric cancer, some studies have demonstrated a correlation between molecular alterations and prognosis, for example, mucins phenotype in gastric dysplasia, and GATA6, TP53 mutation/LOH and MUC6 in early gastric cancer. Moreover, this review considers novelties from the literature regarding the (immuno)histochemical characterization of diffuse-type/signet ring cell gastric cancer, with particular attention to clinical outcomes of patients. The aim of this review is the evaluation of the state of the art regarding suitable biomarkers used in the pre-surgical phase, which can distinguish patients with different prognoses and help decide the best therapeutic strategy. MDPI 2021-06-22 /pmc/articles/PMC8268370/ /pubmed/34206291 http://dx.doi.org/10.3390/ijms22136652 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Battista, Serena Ambrosio, Maria Raffaella Limarzi, Francesco Gallo, Graziana Saragoni, Luca Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer |
title | Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer |
title_full | Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer |
title_fullStr | Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer |
title_full_unstemmed | Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer |
title_short | Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer |
title_sort | molecular alterations in gastric preneoplastic lesions and early gastric cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268370/ https://www.ncbi.nlm.nih.gov/pubmed/34206291 http://dx.doi.org/10.3390/ijms22136652 |
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