Cargando…

Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer

Prognosis of gastric cancer is dramatically improved by early diagnosis. Correa’s cascade correlates the expression of some molecular markers with the progression of preneoplastic lesions toward carcinoma. This article reviews the diagnostic and prognostic values of molecular markers in complete (MU...

Descripción completa

Detalles Bibliográficos
Autores principales: Battista, Serena, Ambrosio, Maria Raffaella, Limarzi, Francesco, Gallo, Graziana, Saragoni, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268370/
https://www.ncbi.nlm.nih.gov/pubmed/34206291
http://dx.doi.org/10.3390/ijms22136652
_version_ 1783720342904111104
author Battista, Serena
Ambrosio, Maria Raffaella
Limarzi, Francesco
Gallo, Graziana
Saragoni, Luca
author_facet Battista, Serena
Ambrosio, Maria Raffaella
Limarzi, Francesco
Gallo, Graziana
Saragoni, Luca
author_sort Battista, Serena
collection PubMed
description Prognosis of gastric cancer is dramatically improved by early diagnosis. Correa’s cascade correlates the expression of some molecular markers with the progression of preneoplastic lesions toward carcinoma. This article reviews the diagnostic and prognostic values of molecular markers in complete (MUC2) and incomplete (MUC2, MUC5AC, and MUC6) intestinal metaplasia, gastric dysplasia/intra-epithelial neoplasia, and early gastric cancer. In particular, considering preinvasive neoplasia and early gastric cancer, some studies have demonstrated a correlation between molecular alterations and prognosis, for example, mucins phenotype in gastric dysplasia, and GATA6, TP53 mutation/LOH and MUC6 in early gastric cancer. Moreover, this review considers novelties from the literature regarding the (immuno)histochemical characterization of diffuse-type/signet ring cell gastric cancer, with particular attention to clinical outcomes of patients. The aim of this review is the evaluation of the state of the art regarding suitable biomarkers used in the pre-surgical phase, which can distinguish patients with different prognoses and help decide the best therapeutic strategy.
format Online
Article
Text
id pubmed-8268370
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-82683702021-07-10 Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer Battista, Serena Ambrosio, Maria Raffaella Limarzi, Francesco Gallo, Graziana Saragoni, Luca Int J Mol Sci Review Prognosis of gastric cancer is dramatically improved by early diagnosis. Correa’s cascade correlates the expression of some molecular markers with the progression of preneoplastic lesions toward carcinoma. This article reviews the diagnostic and prognostic values of molecular markers in complete (MUC2) and incomplete (MUC2, MUC5AC, and MUC6) intestinal metaplasia, gastric dysplasia/intra-epithelial neoplasia, and early gastric cancer. In particular, considering preinvasive neoplasia and early gastric cancer, some studies have demonstrated a correlation between molecular alterations and prognosis, for example, mucins phenotype in gastric dysplasia, and GATA6, TP53 mutation/LOH and MUC6 in early gastric cancer. Moreover, this review considers novelties from the literature regarding the (immuno)histochemical characterization of diffuse-type/signet ring cell gastric cancer, with particular attention to clinical outcomes of patients. The aim of this review is the evaluation of the state of the art regarding suitable biomarkers used in the pre-surgical phase, which can distinguish patients with different prognoses and help decide the best therapeutic strategy. MDPI 2021-06-22 /pmc/articles/PMC8268370/ /pubmed/34206291 http://dx.doi.org/10.3390/ijms22136652 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Battista, Serena
Ambrosio, Maria Raffaella
Limarzi, Francesco
Gallo, Graziana
Saragoni, Luca
Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer
title Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer
title_full Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer
title_fullStr Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer
title_full_unstemmed Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer
title_short Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer
title_sort molecular alterations in gastric preneoplastic lesions and early gastric cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268370/
https://www.ncbi.nlm.nih.gov/pubmed/34206291
http://dx.doi.org/10.3390/ijms22136652
work_keys_str_mv AT battistaserena molecularalterationsingastricpreneoplasticlesionsandearlygastriccancer
AT ambrosiomariaraffaella molecularalterationsingastricpreneoplasticlesionsandearlygastriccancer
AT limarzifrancesco molecularalterationsingastricpreneoplasticlesionsandearlygastriccancer
AT gallograziana molecularalterationsingastricpreneoplasticlesionsandearlygastriccancer
AT saragoniluca molecularalterationsingastricpreneoplasticlesionsandearlygastriccancer