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Cannabinoid Receptors in Myocardial Injury: A Brother Born to Rival

Cannabinoid receptors typically include type 1 (CB1) and type 2 (CB2), and they have attracted extensive attention in the central nervous system (CNS) and immune system. Due to more in-depth studies in recent years, it has been found that the typical CB1 and CB2 receptors confer functional importanc...

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Detalles Bibliográficos
Autores principales: Tang, Xinru, Liu, Zheng, Li, Xiaoqing, Wang, Jing, Li, Liliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268439/
https://www.ncbi.nlm.nih.gov/pubmed/34206926
http://dx.doi.org/10.3390/ijms22136886
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author Tang, Xinru
Liu, Zheng
Li, Xiaoqing
Wang, Jing
Li, Liliang
author_facet Tang, Xinru
Liu, Zheng
Li, Xiaoqing
Wang, Jing
Li, Liliang
author_sort Tang, Xinru
collection PubMed
description Cannabinoid receptors typically include type 1 (CB1) and type 2 (CB2), and they have attracted extensive attention in the central nervous system (CNS) and immune system. Due to more in-depth studies in recent years, it has been found that the typical CB1 and CB2 receptors confer functional importance far beyond the CNS and immune system. In particular, many works have reported the critical involvement of the CB1 and CB2 receptors in myocardial injuries. Both pharmacological and genetic approaches have been used for studying CB1 and CB2 functions in these studies, revealing that the brother receptors have many basic differences and sometimes antagonistic functions in a variety of myocardial injuries, despite some sequence or location identity they share. Herein, we introduce the general differences of CB1 and CB2 cannabinoid receptors, and summarize the functional rivalries between the two brother receptors in the setting of myocardial injuries. We point out the importance of individual receptor-based modulation, instead of dual receptor modulators, when treating myocardial injuries.
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spelling pubmed-82684392021-07-10 Cannabinoid Receptors in Myocardial Injury: A Brother Born to Rival Tang, Xinru Liu, Zheng Li, Xiaoqing Wang, Jing Li, Liliang Int J Mol Sci Review Cannabinoid receptors typically include type 1 (CB1) and type 2 (CB2), and they have attracted extensive attention in the central nervous system (CNS) and immune system. Due to more in-depth studies in recent years, it has been found that the typical CB1 and CB2 receptors confer functional importance far beyond the CNS and immune system. In particular, many works have reported the critical involvement of the CB1 and CB2 receptors in myocardial injuries. Both pharmacological and genetic approaches have been used for studying CB1 and CB2 functions in these studies, revealing that the brother receptors have many basic differences and sometimes antagonistic functions in a variety of myocardial injuries, despite some sequence or location identity they share. Herein, we introduce the general differences of CB1 and CB2 cannabinoid receptors, and summarize the functional rivalries between the two brother receptors in the setting of myocardial injuries. We point out the importance of individual receptor-based modulation, instead of dual receptor modulators, when treating myocardial injuries. MDPI 2021-06-26 /pmc/articles/PMC8268439/ /pubmed/34206926 http://dx.doi.org/10.3390/ijms22136886 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tang, Xinru
Liu, Zheng
Li, Xiaoqing
Wang, Jing
Li, Liliang
Cannabinoid Receptors in Myocardial Injury: A Brother Born to Rival
title Cannabinoid Receptors in Myocardial Injury: A Brother Born to Rival
title_full Cannabinoid Receptors in Myocardial Injury: A Brother Born to Rival
title_fullStr Cannabinoid Receptors in Myocardial Injury: A Brother Born to Rival
title_full_unstemmed Cannabinoid Receptors in Myocardial Injury: A Brother Born to Rival
title_short Cannabinoid Receptors in Myocardial Injury: A Brother Born to Rival
title_sort cannabinoid receptors in myocardial injury: a brother born to rival
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268439/
https://www.ncbi.nlm.nih.gov/pubmed/34206926
http://dx.doi.org/10.3390/ijms22136886
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