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APOE genotype dependent molecular abnormalities in the cerebrovasculature of Alzheimer’s disease and age-matched non-demented brains

Cerebrovascular dysfunction is a hallmark feature of Alzheimer's disease (AD). One of the greatest risk factors for AD is the apolipoprotein E4 (E4) allele. The APOE4 genotype has been shown to negatively impact vascular amyloid clearance, however, its direct influence on the molecular integrit...

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Detalles Bibliográficos
Autores principales:	Ojo, Joseph O., Reed, Jon M., Crynen, Gogce, Vallabhaneni, Prashanthi, Evans, James, Shackleton, Benjamin, Eisenbaum, Maximillian, Ringland, Charis, Edsell, Anastasia, Mullan, Michael, Crawford, Fiona, Bachmeier, Corbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268468/ https://www.ncbi.nlm.nih.gov/pubmed/34238312 http://dx.doi.org/10.1186/s13041-021-00803-9

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