Cargando…

The Role of Small Molecules and Their Effect on the Molecular Mechanisms of Early Retinal Organoid Development

Early in vivo embryonic retinal development is a well-documented and evolutionary conserved process. The specification towards eye development is temporally controlled by consecutive activation or inhibition of multiple key signaling pathways, such as the Wnt and hedgehog signaling pathways. Recentl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wagstaff, Ellie L., Heredero Berzal, Andrea, Boon, Camiel J. F., Quinn, Peter M. J., ten Asbroek, Anneloor L. M. A., Bergen, Arthur A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268497/ https://www.ncbi.nlm.nih.gov/pubmed/34209272 http://dx.doi.org/10.3390/ijms22137081

Ejemplares similares

An alternative approach to produce versatile retinal organoids with accelerated ganglion cell development
por: Wagstaff, Ellie L., et al.
Publicado: (2021)

Rev-Erbα and Photoreceptor Outer Segments modulate the Circadian Clock in Retinal Pigment Epithelial Cells
por: Milićević, Nemanja, et al.
Publicado: (2019)

Characterization and AAV-mediated CRB gene augmentation in human-derived CRB1(KO) and CRB1(KO)CRB2(+/−) retinal organoids
por: Boon, Nanda, et al.
Publicado: (2023)

Retinitis Pigmentosa: Current Clinical Management and Emerging Therapies
por: Nguyen, Xuan-Thanh-An, et al.
Publicado: (2023)

AAV-mediated gene augmentation therapy of CRB1 patient-derived retinal organoids restores the histological and transcriptional retinal phenotype
por: Boon, Nanda, et al.
Publicado: (2023)

A Systematic Review on Transplantation Studies of the Retinal Pigment Epithelium in Animal Models
por: Koster, Céline, et al.
Publicado: (2020)

The Lrat(−/−) Rat: CRISPR/Cas9 Construction and Phenotyping of a New Animal Model for Retinitis Pigmentosa
por: Koster, Céline, et al.
Publicado: (2021)

CRB1 is required for recycling by RAB11A+ vesicles in human retinal organoids
por: Buck, Thilo M., et al.
Publicado: (2023)

Retinal Dystrophies and the Road to Treatment: Clinical Requirements and Considerations
por: Talib, Mays, et al.
Publicado: (2020)

The Prospects for Retinal Organoids in Treatment of Retinal Diseases
por: Xue, Yuntian, et al.
Publicado: (2022)

Retinal Organoids and Retinal Prostheses: An Overview
por: Bellapianta, Alessandro, et al.
Publicado: (2022)

Long-Term Follow-Up of Retinal Degenerations Associated With LRAT Mutations and Their Comparability to Phenotypes Associated With RPE65 Mutations
por: Talib, Mays, et al.
Publicado: (2019)

Generation of liver bipotential organoids with a small-molecule cocktail
por: Wang, Xin, et al.
Publicado: (2020)

Loss of MAPK Pathway Activation in Post-Mitotic Retinal Cells as Mechanism in MEK Inhibition-Related Retinopathy in Cancer Patients
por: van Dijk, Elon H. C., et al.
Publicado: (2016)

Artificial vision: the effectiveness of the OrCam in patients with advanced inherited retinal dystrophies
por: Nguyen, Xuan‐Thanh‐An, et al.
Publicado: (2021)

Retinal organoids: a window into human retinal development
por: O'Hara-Wright, Michelle, et al.
Publicado: (2020)

AAV-mediated gene augmentation therapy of CRB1 patient-derived retinal organoids restores the histological and transcriptional retinal phenotype
por: Boon, Nanda, et al.
Publicado: (2023)

Defining inclusion criteria and endpoints for clinical trials: a prospective cross‐sectional study in CRB1‐associated retinal dystrophies
por: Talib, Mays, et al.
Publicado: (2021)

Organoids for the Study of Retinal Development and Developmental Abnormalities
por: Vielle, Anne, et al.
Publicado: (2021)

A Cleared View on Retinal Organoids
por: Cora, Virginia, et al.
Publicado: (2019)

The Rise of Retinal Organoids for Vision Research
por: Sharma, Kritika, et al.
Publicado: (2020)

Retinal organoids as models for development and diseases
por: Zhang, Xiao, et al.
Publicado: (2021)

Retinal Organoids: Cultivation, Differentiation, and Transplantation
por: Li, Xuying, et al.
Publicado: (2021)

Convolutional Neural Networks Can Predict Retinal Differentiation in Retinal Organoids
por: Kegeles, Evgenii, et al.
Publicado: (2020)

Light-responsive microRNA molecules in human retinal organoids are differentially regulated by distinct wavelengths of light
por: Celiker, Canan, et al.
Publicado: (2023)

RPGR-Associated Dystrophies: Clinical, Genetic, and Histopathological Features
por: Nguyen, Xuan-Thanh-An, et al.
Publicado: (2020)

Special Issue Introduction: Inherited Retinal Disease: Novel Candidate Genes, Genotype–Phenotype Correlations, and Inheritance Models
por: Cremers, Frans P. M., et al.
Publicado: (2018)

Bioengineering Human Pluripotent Stem Cell-Derived Retinal Organoids and Optic Vesicle-Containing Brain Organoids for Ocular Diseases
por: Arthur, Peggy, et al.
Publicado: (2022)

New Drug Discovery Paradigms for Retinal Diseases: A Focus on Retinal Organoids
por: Aasen, Davis M., et al.
Publicado: (2020)

Modeling retinitis pigmentosa through patient-derived retinal organoids
por: Li, Yan-Ping, et al.
Publicado: (2021)

Comparative gene expression study and pathway analysis of the human iris- and the retinal pigment epithelium
por: Bennis, Anna, et al.
Publicado: (2017)

Characterization of Primary Cilia Formation in Human ESC-Derived Retinal Organoids
por: Ning, Ke, et al.
Publicado: (2023)

Retinal organoids provide unique insights into molecular signatures of inherited retinal disease throughout retinogenesis
por: Watson, Avril, et al.
Publicado: (2022)

A look into retinal organoids: methods, analytical techniques, and applications
por: Afanasyeva, Tess A. V., et al.
Publicado: (2021)

Mouse Retinal Organoid Growth and Maintenance in Longer-Term Culture
por: Völkner, Manuela, et al.
Publicado: (2021)

Optogenetic Light Sensors in Human Retinal Organoids
por: Garita-Hernandez, Marcela, et al.
Publicado: (2018)

Retinal Organoid Technology: Where Are We Now?
por: Zhang, Zuming, et al.
Publicado: (2021)

Corrigendum: Retinal Organoids: Cultivation, Differentiation, and Transplantation
por: Li, Xuying, et al.
Publicado: (2021)

Thyroid hormone signaling specifies cone subtypes in human retinal organoids
por: Eldred, Kiara C., et al.
Publicado: (2018)

Retinoblastoma from human stem cell-derived retinal organoids
por: Norrie, Jackie L., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_t08gbacl1t579dnm3f17k7nh5f