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Bleeding Disorders in Primary Fibrinolysis

Fibrinolysis is a complex enzymatic process aimed at dissolving blood clots to prevent vascular occlusions. The fibrinolytic system is composed of a number of cofactors that, by regulating fibrin degradation, maintain the hemostatic balance. A dysregulation of fibrinolysis is associated with various...

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Detalles Bibliográficos
Autores principales: Franchini, Massimo, Zaffanello, Marco, Mannucci, Pier Mannuccio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268566/
https://www.ncbi.nlm.nih.gov/pubmed/34209949
http://dx.doi.org/10.3390/ijms22137027
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author Franchini, Massimo
Zaffanello, Marco
Mannucci, Pier Mannuccio
author_facet Franchini, Massimo
Zaffanello, Marco
Mannucci, Pier Mannuccio
author_sort Franchini, Massimo
collection PubMed
description Fibrinolysis is a complex enzymatic process aimed at dissolving blood clots to prevent vascular occlusions. The fibrinolytic system is composed of a number of cofactors that, by regulating fibrin degradation, maintain the hemostatic balance. A dysregulation of fibrinolysis is associated with various pathological processes that result, depending on the type of abnormality, in prothrombotic or hemorrhagic states. This narrative review is focused on the congenital and acquired disorders of primary fibrinolysis in both adults and children characterized by a hyperfibrinolytic state with a bleeding phenotype.
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spelling pubmed-82685662021-07-10 Bleeding Disorders in Primary Fibrinolysis Franchini, Massimo Zaffanello, Marco Mannucci, Pier Mannuccio Int J Mol Sci Review Fibrinolysis is a complex enzymatic process aimed at dissolving blood clots to prevent vascular occlusions. The fibrinolytic system is composed of a number of cofactors that, by regulating fibrin degradation, maintain the hemostatic balance. A dysregulation of fibrinolysis is associated with various pathological processes that result, depending on the type of abnormality, in prothrombotic or hemorrhagic states. This narrative review is focused on the congenital and acquired disorders of primary fibrinolysis in both adults and children characterized by a hyperfibrinolytic state with a bleeding phenotype. MDPI 2021-06-29 /pmc/articles/PMC8268566/ /pubmed/34209949 http://dx.doi.org/10.3390/ijms22137027 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Franchini, Massimo
Zaffanello, Marco
Mannucci, Pier Mannuccio
Bleeding Disorders in Primary Fibrinolysis
title Bleeding Disorders in Primary Fibrinolysis
title_full Bleeding Disorders in Primary Fibrinolysis
title_fullStr Bleeding Disorders in Primary Fibrinolysis
title_full_unstemmed Bleeding Disorders in Primary Fibrinolysis
title_short Bleeding Disorders in Primary Fibrinolysis
title_sort bleeding disorders in primary fibrinolysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268566/
https://www.ncbi.nlm.nih.gov/pubmed/34209949
http://dx.doi.org/10.3390/ijms22137027
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