Levels of Produced Antibodies after Vaccination with mRNA Vaccine; Effect of Previous Infection with SARS-CoV-2

The aim of this study was to estimate the immunogenic effect of mRNA vaccine against SARS-CoV-2. This study included 510 participants who received mRNA vaccine. The measurement of anti-COVID-19 antibodies was performed using the Abbott SARS-CoV-2 IgG quantitative assay (Abbott). Overall, mean titer...

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Autores principales: Konstantinidis, Theocharis G., Zisaki, Stavroula, Mitroulis, Ioannis, Konstantinidou, Eleni, Kontekaki, Eftychia G., Romanidou, Gioulia, Karvelas, Alexandros, Nanousi, Ioanna, Lazidis, Leonidas, Cassimos, Dimitrios, Tsigalou, Christina, Martinis, Georges, Panopoulou, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268570/
https://www.ncbi.nlm.nih.gov/pubmed/34199029
http://dx.doi.org/10.3390/jcm10132842
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author Konstantinidis, Theocharis G.
Zisaki, Stavroula
Mitroulis, Ioannis
Konstantinidou, Eleni
Kontekaki, Eftychia G.
Romanidou, Gioulia
Karvelas, Alexandros
Nanousi, Ioanna
Lazidis, Leonidas
Cassimos, Dimitrios
Tsigalou, Christina
Martinis, Georges
Panopoulou, Maria
author_facet Konstantinidis, Theocharis G.
Zisaki, Stavroula
Mitroulis, Ioannis
Konstantinidou, Eleni
Kontekaki, Eftychia G.
Romanidou, Gioulia
Karvelas, Alexandros
Nanousi, Ioanna
Lazidis, Leonidas
Cassimos, Dimitrios
Tsigalou, Christina
Martinis, Georges
Panopoulou, Maria
author_sort Konstantinidis, Theocharis G.
collection PubMed
description The aim of this study was to estimate the immunogenic effect of mRNA vaccine against SARS-CoV-2. This study included 510 participants who received mRNA vaccine. The measurement of anti-COVID-19 antibodies was performed using the Abbott SARS-CoV-2 IgG quantitative assay (Abbott). Overall, mean titer of anti-Spike antibodies was 19,319.2 ± 1787.5 AU/mL. Vaccination induced a robust immunogenic response in those previously infected with SARS-CoV-2 compared with non-infected subjects. Additionally, individuals that were asymptomatic after vaccination produced lower levels of antibodies compared to feverish individuals. In conclusion, remarkably high levels of anti-Spike COVID-19 antibodies were observed after vaccination.
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spelling pubmed-82685702021-07-10 Levels of Produced Antibodies after Vaccination with mRNA Vaccine; Effect of Previous Infection with SARS-CoV-2 Konstantinidis, Theocharis G. Zisaki, Stavroula Mitroulis, Ioannis Konstantinidou, Eleni Kontekaki, Eftychia G. Romanidou, Gioulia Karvelas, Alexandros Nanousi, Ioanna Lazidis, Leonidas Cassimos, Dimitrios Tsigalou, Christina Martinis, Georges Panopoulou, Maria J Clin Med Brief Report The aim of this study was to estimate the immunogenic effect of mRNA vaccine against SARS-CoV-2. This study included 510 participants who received mRNA vaccine. The measurement of anti-COVID-19 antibodies was performed using the Abbott SARS-CoV-2 IgG quantitative assay (Abbott). Overall, mean titer of anti-Spike antibodies was 19,319.2 ± 1787.5 AU/mL. Vaccination induced a robust immunogenic response in those previously infected with SARS-CoV-2 compared with non-infected subjects. Additionally, individuals that were asymptomatic after vaccination produced lower levels of antibodies compared to feverish individuals. In conclusion, remarkably high levels of anti-Spike COVID-19 antibodies were observed after vaccination. MDPI 2021-06-27 /pmc/articles/PMC8268570/ /pubmed/34199029 http://dx.doi.org/10.3390/jcm10132842 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Konstantinidis, Theocharis G.
Zisaki, Stavroula
Mitroulis, Ioannis
Konstantinidou, Eleni
Kontekaki, Eftychia G.
Romanidou, Gioulia
Karvelas, Alexandros
Nanousi, Ioanna
Lazidis, Leonidas
Cassimos, Dimitrios
Tsigalou, Christina
Martinis, Georges
Panopoulou, Maria
Levels of Produced Antibodies after Vaccination with mRNA Vaccine; Effect of Previous Infection with SARS-CoV-2
title Levels of Produced Antibodies after Vaccination with mRNA Vaccine; Effect of Previous Infection with SARS-CoV-2
title_full Levels of Produced Antibodies after Vaccination with mRNA Vaccine; Effect of Previous Infection with SARS-CoV-2
title_fullStr Levels of Produced Antibodies after Vaccination with mRNA Vaccine; Effect of Previous Infection with SARS-CoV-2
title_full_unstemmed Levels of Produced Antibodies after Vaccination with mRNA Vaccine; Effect of Previous Infection with SARS-CoV-2
title_short Levels of Produced Antibodies after Vaccination with mRNA Vaccine; Effect of Previous Infection with SARS-CoV-2
title_sort levels of produced antibodies after vaccination with mrna vaccine; effect of previous infection with sars-cov-2
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268570/
https://www.ncbi.nlm.nih.gov/pubmed/34199029
http://dx.doi.org/10.3390/jcm10132842
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