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Elevated retrotransposon activity and genomic instability in primed pluripotent stem cells

BACKGROUND: Naïve and primed pluripotent stem cells (PSCs) represent two different pluripotent states. Primed PSCs following in vitro culture exhibit lower developmental potency as evidenced by failure in germline chimera assays, unlike mouse naïve PSCs. However, the molecular mechanisms underlying...

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Detalles Bibliográficos
Autores principales:	Fu, Haifeng, Zhang, Weiyu, Li, Niannian, Yang, Jiao, Ye, Xiaoying, Tian, Chenglei, Lu, Xinyi, Liu, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268579/ https://www.ncbi.nlm.nih.gov/pubmed/34243810 http://dx.doi.org/10.1186/s13059-021-02417-9

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