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Photosensitizer-Functionalized Nanocomposites for Light-Activated Cancer Theranostics
Photosensitizers (PSs) have received significant attention recently in cancer treatment due to its theranostic capability for imaging and phototherapy. These PSs are highly responsive to light source of a suitable wavelength for image-guided cancer therapy from generated singlet oxygen and/or therma...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268703/ https://www.ncbi.nlm.nih.gov/pubmed/34206318 http://dx.doi.org/10.3390/ijms22136658 |
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author | Dash, Banendu Sunder Das, Suprava Chen, Jyh-Ping |
author_facet | Dash, Banendu Sunder Das, Suprava Chen, Jyh-Ping |
author_sort | Dash, Banendu Sunder |
collection | PubMed |
description | Photosensitizers (PSs) have received significant attention recently in cancer treatment due to its theranostic capability for imaging and phototherapy. These PSs are highly responsive to light source of a suitable wavelength for image-guided cancer therapy from generated singlet oxygen and/or thermal heat. Various organic dye PSs show tremendous attenuation of tumor cells during cancer treatment. Among them, porphyrin and chlorophyll-based ultraviolet-visible (UV-Vis) dyes are employed for photodynamic therapy (PDT) by reactive oxygen species (ROS) and free radicals generated with 400–700 nm laser lights, which have poor tissue penetration depth. To enhance the efficacy of PDT, other light sources such as red light laser and X-ray have been suggested; nonetheless, it is still a challenging task to improve the light penetration depth for deep tumor treatment. To overcome this deficiency, near infrared (NIR) (700–900 nm) PSs, indocyanine green (ICG), and its derivatives like IR780, IR806 and IR820, have been introduced for imaging and phototherapy. These NIR PSs have been used in various cancer treatment modality by combining photothermal therapy (PTT) and/or PDT with chemotherapy or immunotherapy. In this review, we will focus on the use of different PSs showing photothermal/photodynamic response to UV-Vis or NIR-Vis light. The emphasis is a comprehensive review of recent smart design of PS-loaded nanocomposites for targeted delivery of PSs in light-activated combination cancer therapy. |
format | Online Article Text |
id | pubmed-8268703 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82687032021-07-10 Photosensitizer-Functionalized Nanocomposites for Light-Activated Cancer Theranostics Dash, Banendu Sunder Das, Suprava Chen, Jyh-Ping Int J Mol Sci Review Photosensitizers (PSs) have received significant attention recently in cancer treatment due to its theranostic capability for imaging and phototherapy. These PSs are highly responsive to light source of a suitable wavelength for image-guided cancer therapy from generated singlet oxygen and/or thermal heat. Various organic dye PSs show tremendous attenuation of tumor cells during cancer treatment. Among them, porphyrin and chlorophyll-based ultraviolet-visible (UV-Vis) dyes are employed for photodynamic therapy (PDT) by reactive oxygen species (ROS) and free radicals generated with 400–700 nm laser lights, which have poor tissue penetration depth. To enhance the efficacy of PDT, other light sources such as red light laser and X-ray have been suggested; nonetheless, it is still a challenging task to improve the light penetration depth for deep tumor treatment. To overcome this deficiency, near infrared (NIR) (700–900 nm) PSs, indocyanine green (ICG), and its derivatives like IR780, IR806 and IR820, have been introduced for imaging and phototherapy. These NIR PSs have been used in various cancer treatment modality by combining photothermal therapy (PTT) and/or PDT with chemotherapy or immunotherapy. In this review, we will focus on the use of different PSs showing photothermal/photodynamic response to UV-Vis or NIR-Vis light. The emphasis is a comprehensive review of recent smart design of PS-loaded nanocomposites for targeted delivery of PSs in light-activated combination cancer therapy. MDPI 2021-06-22 /pmc/articles/PMC8268703/ /pubmed/34206318 http://dx.doi.org/10.3390/ijms22136658 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dash, Banendu Sunder Das, Suprava Chen, Jyh-Ping Photosensitizer-Functionalized Nanocomposites for Light-Activated Cancer Theranostics |
title | Photosensitizer-Functionalized Nanocomposites for Light-Activated Cancer Theranostics |
title_full | Photosensitizer-Functionalized Nanocomposites for Light-Activated Cancer Theranostics |
title_fullStr | Photosensitizer-Functionalized Nanocomposites for Light-Activated Cancer Theranostics |
title_full_unstemmed | Photosensitizer-Functionalized Nanocomposites for Light-Activated Cancer Theranostics |
title_short | Photosensitizer-Functionalized Nanocomposites for Light-Activated Cancer Theranostics |
title_sort | photosensitizer-functionalized nanocomposites for light-activated cancer theranostics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268703/ https://www.ncbi.nlm.nih.gov/pubmed/34206318 http://dx.doi.org/10.3390/ijms22136658 |
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