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Life and Death of Immature Neurons in the Juvenile and Adult Primate Amygdala

In recent years, a large population of immature neurons has been documented in the paralaminar nucleus of the primate amygdala. A substantial fraction of these immature neurons differentiate into mature neurons during postnatal development or following selective lesion of the hippocampus. Notwithsta...

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Autores principales: Chareyron, Loïc J., Banta Lavenex, Pamela, Amaral, David G., Lavenex, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268704/
https://www.ncbi.nlm.nih.gov/pubmed/34206571
http://dx.doi.org/10.3390/ijms22136691
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author Chareyron, Loïc J.
Banta Lavenex, Pamela
Amaral, David G.
Lavenex, Pierre
author_facet Chareyron, Loïc J.
Banta Lavenex, Pamela
Amaral, David G.
Lavenex, Pierre
author_sort Chareyron, Loïc J.
collection PubMed
description In recent years, a large population of immature neurons has been documented in the paralaminar nucleus of the primate amygdala. A substantial fraction of these immature neurons differentiate into mature neurons during postnatal development or following selective lesion of the hippocampus. Notwithstanding a growing number of studies on the origin and fate of these immature neurons, fundamental questions about the life and death of these neurons remain. Here, we briefly summarize what is currently known about the immature neurons present in the primate ventral amygdala during development and in adulthood, as well as following selective hippocampal lesions. We provide evidence confirming that the distribution of immature neurons extends to the anterior portions of the entorhinal cortex and layer II of the perirhinal cortex. We also provide novel arguments derived from stereological estimates of the number of mature and immature neurons, which support the view that the migration of immature neurons from the lateral ventricle accompanies neuronal maturation in the primate amygdala at all ages. Finally, we propose and discuss the hypothesis that increased migration and maturation of neurons in the amygdala following hippocampal dysfunction may be linked to behavioral alterations associated with certain neurodevelopmental disorders.
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spelling pubmed-82687042021-07-10 Life and Death of Immature Neurons in the Juvenile and Adult Primate Amygdala Chareyron, Loïc J. Banta Lavenex, Pamela Amaral, David G. Lavenex, Pierre Int J Mol Sci Article In recent years, a large population of immature neurons has been documented in the paralaminar nucleus of the primate amygdala. A substantial fraction of these immature neurons differentiate into mature neurons during postnatal development or following selective lesion of the hippocampus. Notwithstanding a growing number of studies on the origin and fate of these immature neurons, fundamental questions about the life and death of these neurons remain. Here, we briefly summarize what is currently known about the immature neurons present in the primate ventral amygdala during development and in adulthood, as well as following selective hippocampal lesions. We provide evidence confirming that the distribution of immature neurons extends to the anterior portions of the entorhinal cortex and layer II of the perirhinal cortex. We also provide novel arguments derived from stereological estimates of the number of mature and immature neurons, which support the view that the migration of immature neurons from the lateral ventricle accompanies neuronal maturation in the primate amygdala at all ages. Finally, we propose and discuss the hypothesis that increased migration and maturation of neurons in the amygdala following hippocampal dysfunction may be linked to behavioral alterations associated with certain neurodevelopmental disorders. MDPI 2021-06-22 /pmc/articles/PMC8268704/ /pubmed/34206571 http://dx.doi.org/10.3390/ijms22136691 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chareyron, Loïc J.
Banta Lavenex, Pamela
Amaral, David G.
Lavenex, Pierre
Life and Death of Immature Neurons in the Juvenile and Adult Primate Amygdala
title Life and Death of Immature Neurons in the Juvenile and Adult Primate Amygdala
title_full Life and Death of Immature Neurons in the Juvenile and Adult Primate Amygdala
title_fullStr Life and Death of Immature Neurons in the Juvenile and Adult Primate Amygdala
title_full_unstemmed Life and Death of Immature Neurons in the Juvenile and Adult Primate Amygdala
title_short Life and Death of Immature Neurons in the Juvenile and Adult Primate Amygdala
title_sort life and death of immature neurons in the juvenile and adult primate amygdala
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268704/
https://www.ncbi.nlm.nih.gov/pubmed/34206571
http://dx.doi.org/10.3390/ijms22136691
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