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Influence of a High-Impact Multidimensional Rehabilitation Program on the Gut Microbiota of Patients with Multiple Sclerosis

Multiple sclerosis (MS) is a neurodegenerative inflammatory condition mediated by autoreactive immune processes. Due to its potential to influence host immunity and gut-brain communication, the gut microbiota has been suggested to be involved in the onset and progression of MS. To date, there is no...

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Autores principales: Barone, Monica, Mendozzi, Laura, D’Amico, Federica, Saresella, Marina, Rampelli, Simone, Piancone, Federica, La Rosa, Francesca, Marventano, Ivana, Clerici, Mario, d’Arma, Alessia, Pugnetti, Luigi, Rossi, Valentina, Candela, Marco, Brigidi, Patrizia, Turroni, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268819/
https://www.ncbi.nlm.nih.gov/pubmed/34281224
http://dx.doi.org/10.3390/ijms22137173
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author Barone, Monica
Mendozzi, Laura
D’Amico, Federica
Saresella, Marina
Rampelli, Simone
Piancone, Federica
La Rosa, Francesca
Marventano, Ivana
Clerici, Mario
d’Arma, Alessia
Pugnetti, Luigi
Rossi, Valentina
Candela, Marco
Brigidi, Patrizia
Turroni, Silvia
author_facet Barone, Monica
Mendozzi, Laura
D’Amico, Federica
Saresella, Marina
Rampelli, Simone
Piancone, Federica
La Rosa, Francesca
Marventano, Ivana
Clerici, Mario
d’Arma, Alessia
Pugnetti, Luigi
Rossi, Valentina
Candela, Marco
Brigidi, Patrizia
Turroni, Silvia
author_sort Barone, Monica
collection PubMed
description Multiple sclerosis (MS) is a neurodegenerative inflammatory condition mediated by autoreactive immune processes. Due to its potential to influence host immunity and gut-brain communication, the gut microbiota has been suggested to be involved in the onset and progression of MS. To date, there is no definitive cure for MS, and rehabilitation programs are of the utmost importance, especially in the later stages. However, only a few people generally participate due to poor support, knowledge, and motivation, and no information is available on gut microbiota changes. Herein we evaluated the potential of a brief high-impact multidimensional rehabilitation program (B-HIPE) in a leisure environment to affect the gut microbiota, mitigate MS symptoms and improve quality of life. B-HIPE resulted in modulation of the MS-typical dysbiosis, with reduced levels of pathobionts and the replenishment of beneficial short-chain fatty acid producers. This partial recovery of a eubiotic profile could help counteract the inflammatory tone typically observed in MS, as supported by reduced circulating lipopolysaccharide levels and decreased populations of pro-inflammatory lymphocytes. Improved physical performance and fatigue relief were also found. Our findings pave the way for integrating clinical practice with holistic approaches to mitigate MS symptoms and improve patients’ quality of life.
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spelling pubmed-82688192021-07-10 Influence of a High-Impact Multidimensional Rehabilitation Program on the Gut Microbiota of Patients with Multiple Sclerosis Barone, Monica Mendozzi, Laura D’Amico, Federica Saresella, Marina Rampelli, Simone Piancone, Federica La Rosa, Francesca Marventano, Ivana Clerici, Mario d’Arma, Alessia Pugnetti, Luigi Rossi, Valentina Candela, Marco Brigidi, Patrizia Turroni, Silvia Int J Mol Sci Article Multiple sclerosis (MS) is a neurodegenerative inflammatory condition mediated by autoreactive immune processes. Due to its potential to influence host immunity and gut-brain communication, the gut microbiota has been suggested to be involved in the onset and progression of MS. To date, there is no definitive cure for MS, and rehabilitation programs are of the utmost importance, especially in the later stages. However, only a few people generally participate due to poor support, knowledge, and motivation, and no information is available on gut microbiota changes. Herein we evaluated the potential of a brief high-impact multidimensional rehabilitation program (B-HIPE) in a leisure environment to affect the gut microbiota, mitigate MS symptoms and improve quality of life. B-HIPE resulted in modulation of the MS-typical dysbiosis, with reduced levels of pathobionts and the replenishment of beneficial short-chain fatty acid producers. This partial recovery of a eubiotic profile could help counteract the inflammatory tone typically observed in MS, as supported by reduced circulating lipopolysaccharide levels and decreased populations of pro-inflammatory lymphocytes. Improved physical performance and fatigue relief were also found. Our findings pave the way for integrating clinical practice with holistic approaches to mitigate MS symptoms and improve patients’ quality of life. MDPI 2021-07-02 /pmc/articles/PMC8268819/ /pubmed/34281224 http://dx.doi.org/10.3390/ijms22137173 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Barone, Monica
Mendozzi, Laura
D’Amico, Federica
Saresella, Marina
Rampelli, Simone
Piancone, Federica
La Rosa, Francesca
Marventano, Ivana
Clerici, Mario
d’Arma, Alessia
Pugnetti, Luigi
Rossi, Valentina
Candela, Marco
Brigidi, Patrizia
Turroni, Silvia
Influence of a High-Impact Multidimensional Rehabilitation Program on the Gut Microbiota of Patients with Multiple Sclerosis
title Influence of a High-Impact Multidimensional Rehabilitation Program on the Gut Microbiota of Patients with Multiple Sclerosis
title_full Influence of a High-Impact Multidimensional Rehabilitation Program on the Gut Microbiota of Patients with Multiple Sclerosis
title_fullStr Influence of a High-Impact Multidimensional Rehabilitation Program on the Gut Microbiota of Patients with Multiple Sclerosis
title_full_unstemmed Influence of a High-Impact Multidimensional Rehabilitation Program on the Gut Microbiota of Patients with Multiple Sclerosis
title_short Influence of a High-Impact Multidimensional Rehabilitation Program on the Gut Microbiota of Patients with Multiple Sclerosis
title_sort influence of a high-impact multidimensional rehabilitation program on the gut microbiota of patients with multiple sclerosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268819/
https://www.ncbi.nlm.nih.gov/pubmed/34281224
http://dx.doi.org/10.3390/ijms22137173
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