Neoantigen vaccination induces clinical and immunologic responses in non-small cell lung cancer patients harboring EGFR mutations

BACKGROUND: Neoantigen (NeoAg) peptides displayed at the tumor cell surface by human leukocyte antigen molecules show exquisite tumor specificity and can elicit T cell mediated tumor rejection. However, few NeoAgs are predicted to be shared between patients, and none to date have demonstrated therap...

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Autores principales: Li, Fenge, Deng, Ligang, Jackson, Kyle R, Talukder, Amjad H, Katailiha, Arjun S, Bradley, Sherille D, Zou, Qingwei, Chen, Caixia, Huo, Chong, Chiu, Yulun, Stair, Matthew, Feng, Weihong, Bagaev, Aleksander, Kotlov, Nikita, Svekolkin, Viktor, Ataullakhanov, Ravshan, Miheecheva, Natalia, Frenkel, Felix, Wang, Yaling, Zhang, Minying, Hawke, David, Han, Ling, Zhou, Shuo, Zhang, Yan, Wang, Zhenglu, Decker, William K, Sonnemann, Heather M, Roszik, Jason, Forget, Marie-Andree, Davies, Michael A, Bernatchez, Chantale, Yee, Cassian, Bassett, Roland, Hwu, Patrick, Du, Xueming, Lizee, Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268925/
https://www.ncbi.nlm.nih.gov/pubmed/34244308
http://dx.doi.org/10.1136/jitc-2021-002531

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