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Membrane Interactions Accelerate the Self-Aggregation of Huntingtin Exon 1 Fragments in a Polyglutamine Length-Dependent Manner

The accumulation of aggregated protein is a typical hallmark of many human neurodegenerative disorders, including polyglutamine-related diseases such as chorea Huntington. Misfolding of the amyloidogenic proteins gives rise to self-assembled complexes and fibres. The huntingtin protein is characteri...

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Detalles Bibliográficos
Autores principales:	Marquette, Arnaud, Aisenbrey, Christopher, Bechinger, Burkhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268948/ https://www.ncbi.nlm.nih.gov/pubmed/34201610 http://dx.doi.org/10.3390/ijms22136725

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