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Bisphenol a Interferes with Uterine Artery Features and Impairs Rat Feto-Placental Growth

Bisphenol A (BPA) is a widespread environmental contaminant, found in human fluids and tissues. Maternal BPA exposure is associated with alterations in pregnancy outcomes. Because maternal uterine circulation plays a crucial role in normal placenta and fetal growth, we hypothesized that BPA compromi...

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Autores principales: Barberio, Laura, Paulesu, Luana, Canesi, Laura, Grasselli, Elena, Mandalà, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268965/
https://www.ncbi.nlm.nih.gov/pubmed/34199136
http://dx.doi.org/10.3390/ijms22136912
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author Barberio, Laura
Paulesu, Luana
Canesi, Laura
Grasselli, Elena
Mandalà, Maurizio
author_facet Barberio, Laura
Paulesu, Luana
Canesi, Laura
Grasselli, Elena
Mandalà, Maurizio
author_sort Barberio, Laura
collection PubMed
description Bisphenol A (BPA) is a widespread environmental contaminant, found in human fluids and tissues. Maternal BPA exposure is associated with alterations in pregnancy outcomes. Because maternal uterine circulation plays a crucial role in normal placenta and fetal growth, we hypothesized that BPA compromises the function of uterine arteries (UAs) and fetoplacental development. Female rats were orally administered with BPA (2.5, 25 and 250 µg/kg/day) or with its vehicle (ethanol) for 30 days before pregnancy and during the first 20 days of pregnancy. To compare the effect of BPA in the reproductive vs. systemic circulation, it was tested on UAs and mesenteric arteries (MAs). Arteries were isolated and examined by pressure myography. Moreover, fetuses and placentas were weighed to provide an index of reproductive performance. In UAs of BPA-treated rats, lumen diameter, acetylcholine-relaxation and expressions of endothelial nitric oxide synthase 3 (NOS3), estrogen receptor α (ERα) and peroxisome proliferator-activated receptor ɣ (PPARɣ) were reduced. Conversely, no changes were observed in MAs. BPA treatment also reduced placental weights, while fetal weights were increased. For the first time, our results indicate that UAs represent a specific target of BPA during pregnancy and provide insight into the molecular mechanisms that underlie its negative effects on pregnancy outcomes.
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spelling pubmed-82689652021-07-10 Bisphenol a Interferes with Uterine Artery Features and Impairs Rat Feto-Placental Growth Barberio, Laura Paulesu, Luana Canesi, Laura Grasselli, Elena Mandalà, Maurizio Int J Mol Sci Article Bisphenol A (BPA) is a widespread environmental contaminant, found in human fluids and tissues. Maternal BPA exposure is associated with alterations in pregnancy outcomes. Because maternal uterine circulation plays a crucial role in normal placenta and fetal growth, we hypothesized that BPA compromises the function of uterine arteries (UAs) and fetoplacental development. Female rats were orally administered with BPA (2.5, 25 and 250 µg/kg/day) or with its vehicle (ethanol) for 30 days before pregnancy and during the first 20 days of pregnancy. To compare the effect of BPA in the reproductive vs. systemic circulation, it was tested on UAs and mesenteric arteries (MAs). Arteries were isolated and examined by pressure myography. Moreover, fetuses and placentas were weighed to provide an index of reproductive performance. In UAs of BPA-treated rats, lumen diameter, acetylcholine-relaxation and expressions of endothelial nitric oxide synthase 3 (NOS3), estrogen receptor α (ERα) and peroxisome proliferator-activated receptor ɣ (PPARɣ) were reduced. Conversely, no changes were observed in MAs. BPA treatment also reduced placental weights, while fetal weights were increased. For the first time, our results indicate that UAs represent a specific target of BPA during pregnancy and provide insight into the molecular mechanisms that underlie its negative effects on pregnancy outcomes. MDPI 2021-06-27 /pmc/articles/PMC8268965/ /pubmed/34199136 http://dx.doi.org/10.3390/ijms22136912 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Barberio, Laura
Paulesu, Luana
Canesi, Laura
Grasselli, Elena
Mandalà, Maurizio
Bisphenol a Interferes with Uterine Artery Features and Impairs Rat Feto-Placental Growth
title Bisphenol a Interferes with Uterine Artery Features and Impairs Rat Feto-Placental Growth
title_full Bisphenol a Interferes with Uterine Artery Features and Impairs Rat Feto-Placental Growth
title_fullStr Bisphenol a Interferes with Uterine Artery Features and Impairs Rat Feto-Placental Growth
title_full_unstemmed Bisphenol a Interferes with Uterine Artery Features and Impairs Rat Feto-Placental Growth
title_short Bisphenol a Interferes with Uterine Artery Features and Impairs Rat Feto-Placental Growth
title_sort bisphenol a interferes with uterine artery features and impairs rat feto-placental growth
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268965/
https://www.ncbi.nlm.nih.gov/pubmed/34199136
http://dx.doi.org/10.3390/ijms22136912
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