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From Genetics to Histomolecular Characterization: An Insight into Colorectal Carcinogenesis in Lynch Syndrome

Lynch syndrome is a hereditary cancer-predisposing syndrome caused by germline defects in DNA mismatch repair (MMR) genes such as MLH1, MSH2, MSH6, and PMS2. Carriers of pathogenic mutations in these genes have an increased lifetime risk of developing colorectal cancer (CRC) and other malignancies....

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Detalles Bibliográficos
Autores principales:	Lepore Signorile, Martina, Disciglio, Vittoria, Di Carlo, Gabriella, Pisani, Antonio, Simone, Cristiano, Ingravallo, Giuseppe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8268977/ https://www.ncbi.nlm.nih.gov/pubmed/34201893 http://dx.doi.org/10.3390/ijms22136767

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