Cargando…

Repurposing Niclosamide for Targeting Pancreatic Cancer by Inhibiting Hh/Gli Non-Canonical Axis of Gsk3β

SIMPLE SUMMARY: The current obstacles for discovering new drugs for cancer therapy have necessitated the development of the alternative strategy of drug repurposing, the identification of new uses for approved or investigational drugs for new therapeutic purposes. Niclosamide (Nic) is a Food and Dru...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kaushal, Jyoti B., Bhatia, Rakesh, Kanchan, Ranjana K., Raut, Pratima, Mallapragada, Surya, Ly, Quan P., Batra, Surinder K., Rachagani, Satyanarayana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269055/ https://www.ncbi.nlm.nih.gov/pubmed/34206370 http://dx.doi.org/10.3390/cancers13133105

Ejemplares similares

Correction: Kaushal et al. Repurposing Niclosamide for Targeting Pancreatic Cancer by Inhibiting Hh/Gli Non-Canonical Axis of Gsk3β. Cancers 2021, 13, 3105
por: Kaushal, Jyoti B., et al.
Publicado: (2021)

The regulation of Hh/Gli1 signaling cascade involves Gsk3β- mediated mechanism in estrogen-derived endometrial hyperplasia
por: Kaushal, Jyoti Bala, et al.
Publicado: (2017)

MEDB-87. Transcriptome-driven drug repurposing in group 3 medulloblastoma
por: Doss, David, et al.
Publicado: (2022)

MDB-40. TRANSCRIPTOME-BASED DRUG REPURPOSING IN GROUP 3 MEDULLOBLASTOMA
por: Doss, David, et al.
Publicado: (2023)

Repurposing niclosamide for the treatment of neurological disorders
por: Apolloni, Savina, et al.
Publicado: (2023)

Emerging Role of miR-345 and Its Effective Delivery as a Potential Therapeutic Candidate in Pancreatic Cancer and Other Cancers
por: Natesh, Nagabhishek Sirpu, et al.
Publicado: (2021)

Repurposing the anthelmintic drug niclosamide to combat Helicobacter pylori
por: Tharmalingam, Nagendran, et al.
Publicado: (2018)

Niclosamide Triggers Non-Canonical LC3 Lipidation
por: Liu, Yajun, et al.
Publicado: (2019)

Drug Repurposing of the Anthelmintic Niclosamide to Treat Multidrug-Resistant Leukemia
por: Hamdoun, Sami, et al.
Publicado: (2017)

Investigation of niclosamide as a repurposing agent for skeletal muscle atrophy
por: Kim, Hyun-Jun, et al.
Publicado: (2021)

Gut microbiota: a non-target victim of pesticide-induced toxicity
por: Sharma, Tusha, et al.
Publicado: (2023)

Computational Screening Strategy for Drug Repurposing Identified Niclosamide as Inhibitor of Vascular Calcification
por: Tanaka, Takeshi, et al.
Publicado: (2022)

Niclosamide as a Repurposing Drug against Corynebacterium striatum Multidrug-Resistant Infections
por: Folliero, Veronica, et al.
Publicado: (2022)

PD2/Paf1 depletion in pancreatic acinar cells promotes acinar-to-ductal metaplasia
por: Dey, Parama, et al.
Publicado: (2014)

CRKL is a critical target of Hh‐GLI2 pathway in lung adenocarcinoma
por: Liu, Xiaoming, et al.
Publicado: (2021)

Repurposing Niclosamide as a Therapeutic Drug against Acute Liver Failure by Suppressing Ferroptosis
por: Zhong, Xiao, et al.
Publicado: (2023)

Niclosamide is a potential therapeutic for familial adenomatosis polyposis by disrupting Axin-GSK3 interaction
por: Ahn, Sung Yong, et al.
Publicado: (2017)

Anti-helminthic niclosamide inhibits Ras-driven oncogenic transformation via activation of GSK-3
por: Ahn, Sung Yong, et al.
Publicado: (2017)

CXCR2 signaling regulates KRAS((G12D))-induced autocrine growth of pancreatic cancer
por: Purohit, Abhilasha, et al.
Publicado: (2016)

Non-Canonical Hh Signaling in Cancer—Current Understanding and Future Directions
por: Gu, Dongsheng, et al.
Publicado: (2015)

Novel Pancreatic Cancer Cell Lines Derived from Genetically Engineered Mouse Models of Spontaneous Pancreatic Adenocarcinoma: Applications in Diagnosis and Therapy
por: Torres, María P., et al.
Publicado: (2013)

Membrane proximal ectodomain cleavage of MUC16 occurs in the acidifying Golgi/post-Golgi compartments
por: Das, Srustidhar, et al.
Publicado: (2015)

Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting
por: Pothuraju, Ramesh, et al.
Publicado: (2018)

Mucins, gut microbiota, and postbiotics role in colorectal cancer
por: Pothuraju, Ramesh, et al.
Publicado: (2021)

Histidine Enhances the Anticancer Effect of Gemcitabine against Pancreatic Cancer via Disruption of Amino Acid Homeostasis and Oxidant—Antioxidant Balance
por: Kumar, Narendra, et al.
Publicado: (2023)

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways
por: Miner, Kent, et al.
Publicado: (2019)

Gli1(+) progenitors mediate bone anabolic function of teriparatide via Hh and Igf signaling
por: Shi, Yu, et al.
Publicado: (2021)

Comparative Study of Subcutaneous and Orthotopic Mouse Models of Prostate Cancer: Vascular Perfusion, Vasculature Density, Hypoxic Burden and BB2r-Targeting Efficacy
por: Zhang, Wenting, et al.
Publicado: (2019)

Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells
por: Barkeer, Srikanth, et al.
Publicado: (2018)

An Integrated Bioinformatics Analysis Repurposes an Antihelminthic Drug Niclosamide for Treating HMGA2-Overexpressing Human Colorectal Cancer
por: Leung, Stephen Wan, et al.
Publicado: (2019)

Repurposing niclosamide as a novel anti-SARS-Cov-2 drug by restricting entry protein CD147
por: Yang, Zhe, et al.
Publicado: (2023)

Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene
por: Masetti, Riccardo, et al.
Publicado: (2017)

A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human
por: Singh, Bhairab N., et al.
Publicado: (2018)

The magic bullet: Niclosamide
por: Jiang, Haowen, et al.
Publicado: (2022)

Niclosamide Inhibits Aortic Valve Interstitial Cell Calcification by Interfering with the GSK-3β/β-Catenin Signaling Pathway
por: Adhikari, Radhika, et al.
Publicado: (2023)

Nicotine/Cigarette-smoke Promotes Metastasis of Pancreatic Cancer Through α7nAChR-mediated MUC4 Up-regulation
por: Momi, Navneet, et al.
Publicado: (2012)

Inhibition of hedgehog signaling improves the anti-carcinogenic effects of docetaxel in prostate cancer
por: Mimeault, Murielle, et al.
Publicado: (2015)

Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer
por: Seshacharyulu, Parthasarathy, et al.
Publicado: (2014)

Ubiquitous Aberration in Cholesterol Metabolism across Pancreatic Ductal Adenocarcinoma
por: Gunda, Venugopal, et al.
Publicado: (2022)

Repurposing Niclosamide as a Novel Anti-SARS-CoV-2 Drug by Restricting Entry Protein CD147
por: Yang, Zhe, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_tc0bk0qvmi4dvb2b4vq9v8k57c