Tumor-Associated Macrophages: Combination of Therapies, the Approach to Improve Cancer Treatment

Macrophages are one of the most important cells of the innate immune system and are known for their ability to engulf and digest foreign substances, including cellular debris and tumor cells. They can convert into tumor-associated macrophages (TAMs) when mature macrophages are recruited into the tum...

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Detalles Bibliográficos
Autores principales: Moeini, Pedram, Niedźwiedzka-Rystwej, Paulina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269174/
https://www.ncbi.nlm.nih.gov/pubmed/34281293
http://dx.doi.org/10.3390/ijms22137239
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author Moeini, Pedram
Niedźwiedzka-Rystwej, Paulina
author_facet Moeini, Pedram
Niedźwiedzka-Rystwej, Paulina
author_sort Moeini, Pedram
collection PubMed
description Macrophages are one of the most important cells of the innate immune system and are known for their ability to engulf and digest foreign substances, including cellular debris and tumor cells. They can convert into tumor-associated macrophages (TAMs) when mature macrophages are recruited into the tumor microenvironment. Their role in cancer progression, metastasis, and therapy failure is of special note. The aim of this review is to understand how the presence of TAMs are both advantageous and disadvantageous in the immune system.
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spelling pubmed-82691742021-07-10 Tumor-Associated Macrophages: Combination of Therapies, the Approach to Improve Cancer Treatment Moeini, Pedram Niedźwiedzka-Rystwej, Paulina Int J Mol Sci Review Macrophages are one of the most important cells of the innate immune system and are known for their ability to engulf and digest foreign substances, including cellular debris and tumor cells. They can convert into tumor-associated macrophages (TAMs) when mature macrophages are recruited into the tumor microenvironment. Their role in cancer progression, metastasis, and therapy failure is of special note. The aim of this review is to understand how the presence of TAMs are both advantageous and disadvantageous in the immune system. MDPI 2021-07-05 /pmc/articles/PMC8269174/ /pubmed/34281293 http://dx.doi.org/10.3390/ijms22137239 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Moeini, Pedram
Niedźwiedzka-Rystwej, Paulina
Tumor-Associated Macrophages: Combination of Therapies, the Approach to Improve Cancer Treatment
title Tumor-Associated Macrophages: Combination of Therapies, the Approach to Improve Cancer Treatment
title_full Tumor-Associated Macrophages: Combination of Therapies, the Approach to Improve Cancer Treatment
title_fullStr Tumor-Associated Macrophages: Combination of Therapies, the Approach to Improve Cancer Treatment
title_full_unstemmed Tumor-Associated Macrophages: Combination of Therapies, the Approach to Improve Cancer Treatment
title_short Tumor-Associated Macrophages: Combination of Therapies, the Approach to Improve Cancer Treatment
title_sort tumor-associated macrophages: combination of therapies, the approach to improve cancer treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269174/
https://www.ncbi.nlm.nih.gov/pubmed/34281293
http://dx.doi.org/10.3390/ijms22137239
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