Deep Learning-Based Stage-Wise Risk Stratification for Early Lung Adenocarcinoma in CT Images: A Multi-Center Study

SIMPLE SUMMARY: Prediction of the malignancy and invasiveness of ground glass nodules (GGNs) from computed tomography images is a crucial task for radiologists in risk stratification of early-stage lung adenocarcinoma. In order to solve this challenge, a two-stage deep neural network (DNN) was developed based on the images collected from four centers. A multi-reader multi-case observer study was conducted to evaluate the model capability. The performance of our model was comparable or even more accurate than that of senior radiologists, with average area under the curve values of 0.76 and 0.95 for two tasks, respectively. Findings suggest (1) a positive trend between the diagnostic performance and radiologist’s experience, (2) DNN yielded equivalent or even higher performance in comparison with senior radiologists, and (3) low image resolution reduced the model performance in predicting the risks of GGNs. ABSTRACT: This study aims to develop a deep neural network (DNN)-based two-stage risk stratification model for early lung adenocarcinomas in CT images, and investigate the performance compared with practicing radiologists. A total of 2393 GGNs were retrospectively collected from 2105 patients in four centers. All the pathologic results of GGNs were obtained from surgically resected specimens. A two-stage deep neural network was developed based on the 3D residual network and atrous convolution module to diagnose benign and malignant GGNs (Task1) and classify between invasive adenocarcinoma (IA) and non-IA for these malignant GGNs (Task2). A multi-reader multi-case observer study with six board-certified radiologists’ (average experience 11 years, range 2–28 years) participation was conducted to evaluate the model capability. DNN yielded area under the receiver operating characteristic curve (AUC) values of 0.76 ± 0.03 (95% confidence interval (CI): (0.69, 0.82)) and 0.96 ± 0.02 (95% CI: (0.92, 0.98)) for Task1 and Task2, which were equivalent to or higher than radiologists in the senior group with average AUC values of 0.76 and 0.95, respectively (p > 0.05). With the CT image slice thickness increasing from 1.15 mm ± 0.36 to 1.73 mm ± 0.64, DNN performance decreased 0.08 and 0.22 for the two tasks. The results demonstrated (1) a positive trend between the diagnostic performance and radiologist’s experience, (2) the DNN yielded equivalent or even higher performance in comparison with senior radiologists, and (3) low image resolution decreased model performance in predicting the risks of GGNs. Once tested prospectively in clinical practice, the DNN could have the potential to assist doctors in precision diagnosis and treatment of early lung adenocarcinoma.