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Molecular and Neural Mechanism of Dysphagia Due to Cancer

Cancer is one of the most common causes of death worldwide. Along with the advances in diagnostic technology achieved through industry–academia partnerships, the survival rate of cancer patients has improved dramatically through treatments that include surgery, radiation therapy, and pharmacotherapy...

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Detalles Bibliográficos
Autores principales: Okuni, Ikuko, Otsubo, Yuta, Ebihara, Satoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269194/
https://www.ncbi.nlm.nih.gov/pubmed/34210012
http://dx.doi.org/10.3390/ijms22137033
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author Okuni, Ikuko
Otsubo, Yuta
Ebihara, Satoru
author_facet Okuni, Ikuko
Otsubo, Yuta
Ebihara, Satoru
author_sort Okuni, Ikuko
collection PubMed
description Cancer is one of the most common causes of death worldwide. Along with the advances in diagnostic technology achieved through industry–academia partnerships, the survival rate of cancer patients has improved dramatically through treatments that include surgery, radiation therapy, and pharmacotherapy. This has increased the population of cancer “survivors” and made cancer survivorship an important part of life for patients. The senses of taste and smell during swallowing and cachexia play important roles in dysphagia associated with nutritional disorders in cancer patients. Cancerous lesions in the brain can cause dysphagia. Taste and smell disorders that contribute to swallowing can worsen or develop because of pharmacotherapy or radiation therapy; metabolic or central nervous system damage due to cachexia, sarcopenia, or inflammation can also cause dysphagia. As the causes of eating disorders in cancer patients are complex and involve multiple factors, cancer patients require a multifaceted and long-term approach by the medical care team.
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spelling pubmed-82691942021-07-10 Molecular and Neural Mechanism of Dysphagia Due to Cancer Okuni, Ikuko Otsubo, Yuta Ebihara, Satoru Int J Mol Sci Review Cancer is one of the most common causes of death worldwide. Along with the advances in diagnostic technology achieved through industry–academia partnerships, the survival rate of cancer patients has improved dramatically through treatments that include surgery, radiation therapy, and pharmacotherapy. This has increased the population of cancer “survivors” and made cancer survivorship an important part of life for patients. The senses of taste and smell during swallowing and cachexia play important roles in dysphagia associated with nutritional disorders in cancer patients. Cancerous lesions in the brain can cause dysphagia. Taste and smell disorders that contribute to swallowing can worsen or develop because of pharmacotherapy or radiation therapy; metabolic or central nervous system damage due to cachexia, sarcopenia, or inflammation can also cause dysphagia. As the causes of eating disorders in cancer patients are complex and involve multiple factors, cancer patients require a multifaceted and long-term approach by the medical care team. MDPI 2021-06-29 /pmc/articles/PMC8269194/ /pubmed/34210012 http://dx.doi.org/10.3390/ijms22137033 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Okuni, Ikuko
Otsubo, Yuta
Ebihara, Satoru
Molecular and Neural Mechanism of Dysphagia Due to Cancer
title Molecular and Neural Mechanism of Dysphagia Due to Cancer
title_full Molecular and Neural Mechanism of Dysphagia Due to Cancer
title_fullStr Molecular and Neural Mechanism of Dysphagia Due to Cancer
title_full_unstemmed Molecular and Neural Mechanism of Dysphagia Due to Cancer
title_short Molecular and Neural Mechanism of Dysphagia Due to Cancer
title_sort molecular and neural mechanism of dysphagia due to cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269194/
https://www.ncbi.nlm.nih.gov/pubmed/34210012
http://dx.doi.org/10.3390/ijms22137033
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