Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways

Pattern recognition receptors (PRRs) form the front line of defense against pathogens. Many of the molecular mechanisms that facilitate PRR signaling have been characterized in detail, which is critical for the development of accurate PRR pathway models at the molecular interaction level. These mode...

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Detalles Bibliográficos
Autores principales: Manes, Nathan P., Nita-Lazar, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269223/
https://www.ncbi.nlm.nih.gov/pubmed/34184910
http://dx.doi.org/10.1128/mSystems.00336-21
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author Manes, Nathan P.
Nita-Lazar, Aleksandra
author_facet Manes, Nathan P.
Nita-Lazar, Aleksandra
author_sort Manes, Nathan P.
collection PubMed
description Pattern recognition receptors (PRRs) form the front line of defense against pathogens. Many of the molecular mechanisms that facilitate PRR signaling have been characterized in detail, which is critical for the development of accurate PRR pathway models at the molecular interaction level. These models could support the development of therapeutics for numerous diseases, including sepsis and COVID-19. This review describes the molecular mechanisms of the principal signaling interactions of the Toll-like receptor, STING, MAVS, and inflammasome pathways. A detailed molecular mechanism network is included as Data Set S1 in the supplemental material.
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spelling pubmed-82692232021-08-02 Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways Manes, Nathan P. Nita-Lazar, Aleksandra mSystems Minireview Pattern recognition receptors (PRRs) form the front line of defense against pathogens. Many of the molecular mechanisms that facilitate PRR signaling have been characterized in detail, which is critical for the development of accurate PRR pathway models at the molecular interaction level. These models could support the development of therapeutics for numerous diseases, including sepsis and COVID-19. This review describes the molecular mechanisms of the principal signaling interactions of the Toll-like receptor, STING, MAVS, and inflammasome pathways. A detailed molecular mechanism network is included as Data Set S1 in the supplemental material. American Society for Microbiology 2021-06-29 /pmc/articles/PMC8269223/ /pubmed/34184910 http://dx.doi.org/10.1128/mSystems.00336-21 Text en https://doi.org/10.1128/AuthorWarrantyLicense.v1This is a work of the U.S. Government and is not subject to copyright protection in the United States. Foreign copyrights may apply.
spellingShingle Minireview
Manes, Nathan P.
Nita-Lazar, Aleksandra
Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways
title Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways
title_full Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways
title_fullStr Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways
title_full_unstemmed Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways
title_short Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways
title_sort molecular mechanisms of the toll-like receptor, sting, mavs, inflammasome, and interferon pathways
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269223/
https://www.ncbi.nlm.nih.gov/pubmed/34184910
http://dx.doi.org/10.1128/mSystems.00336-21
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