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External Validation of the IOTA Classification in Women with Ovarian Masses Suspected to Be Endometrioma

The study aimed to perform external validation of the International Ovarian Tumor Analysis (IOTA) classification of adnexal masses as benign or malignant in women with suspected endometrioma. A retrospective study including women referred to an endometriosis tertiary referral center for dedicated tr...

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Autores principales: Cohen Ben-Meir, Lee, Mashiach, Roy, Eisenberg, Vered H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269298/
https://www.ncbi.nlm.nih.gov/pubmed/34279456
http://dx.doi.org/10.3390/jcm10132971
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author Cohen Ben-Meir, Lee
Mashiach, Roy
Eisenberg, Vered H.
author_facet Cohen Ben-Meir, Lee
Mashiach, Roy
Eisenberg, Vered H.
author_sort Cohen Ben-Meir, Lee
collection PubMed
description The study aimed to perform external validation of the International Ovarian Tumor Analysis (IOTA) classification of adnexal masses as benign or malignant in women with suspected endometrioma. A retrospective study including women referred to an endometriosis tertiary referral center for dedicated transvaginal ultrasound (TVUS). Adnexal masses were evaluated using the IOTA classification simple descriptors, simple rules and expert opinion. The reference standard was definitive histology after mass removal at laparoscopy. In total, 621 women were evaluated and divided into four groups: endometrioma on TVUS and confirmed on surgery (Group 1 = 181), endometrioma on TVUS but other benign cysts on surgery (Group 2 = 9), other cysts on TVUS but endometrioma on surgery (Group 3 = 2), masses classified as other findings or suspicious for malignancy on TVUS and confirmed on surgery (Group 4 = 5 potentially malignant, 11 benign). This gave a sensitivity 98.9%, specificity 64%, positive 95.3% and negative 88.9% predictive values, positive 2.74 and negative 0.02 likelihood ratios and 94.7% overall accuracy. The surgical diagnosis for the five masses suspected to be malignant was: borderline serous tumor (2), borderline mucinous tumor (2), and endometrioid lesion with complex hyperplasia without atypia (1). The conclusions were that the IOTA classification simple descriptors, simple rules and expert opinion performs well for classifying adnexal masses suspected to be endometrioma. The most common potentially malignant masses in these women were borderline ovarian tumors.
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spelling pubmed-82692982021-07-10 External Validation of the IOTA Classification in Women with Ovarian Masses Suspected to Be Endometrioma Cohen Ben-Meir, Lee Mashiach, Roy Eisenberg, Vered H. J Clin Med Article The study aimed to perform external validation of the International Ovarian Tumor Analysis (IOTA) classification of adnexal masses as benign or malignant in women with suspected endometrioma. A retrospective study including women referred to an endometriosis tertiary referral center for dedicated transvaginal ultrasound (TVUS). Adnexal masses were evaluated using the IOTA classification simple descriptors, simple rules and expert opinion. The reference standard was definitive histology after mass removal at laparoscopy. In total, 621 women were evaluated and divided into four groups: endometrioma on TVUS and confirmed on surgery (Group 1 = 181), endometrioma on TVUS but other benign cysts on surgery (Group 2 = 9), other cysts on TVUS but endometrioma on surgery (Group 3 = 2), masses classified as other findings or suspicious for malignancy on TVUS and confirmed on surgery (Group 4 = 5 potentially malignant, 11 benign). This gave a sensitivity 98.9%, specificity 64%, positive 95.3% and negative 88.9% predictive values, positive 2.74 and negative 0.02 likelihood ratios and 94.7% overall accuracy. The surgical diagnosis for the five masses suspected to be malignant was: borderline serous tumor (2), borderline mucinous tumor (2), and endometrioid lesion with complex hyperplasia without atypia (1). The conclusions were that the IOTA classification simple descriptors, simple rules and expert opinion performs well for classifying adnexal masses suspected to be endometrioma. The most common potentially malignant masses in these women were borderline ovarian tumors. MDPI 2021-07-01 /pmc/articles/PMC8269298/ /pubmed/34279456 http://dx.doi.org/10.3390/jcm10132971 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cohen Ben-Meir, Lee
Mashiach, Roy
Eisenberg, Vered H.
External Validation of the IOTA Classification in Women with Ovarian Masses Suspected to Be Endometrioma
title External Validation of the IOTA Classification in Women with Ovarian Masses Suspected to Be Endometrioma
title_full External Validation of the IOTA Classification in Women with Ovarian Masses Suspected to Be Endometrioma
title_fullStr External Validation of the IOTA Classification in Women with Ovarian Masses Suspected to Be Endometrioma
title_full_unstemmed External Validation of the IOTA Classification in Women with Ovarian Masses Suspected to Be Endometrioma
title_short External Validation of the IOTA Classification in Women with Ovarian Masses Suspected to Be Endometrioma
title_sort external validation of the iota classification in women with ovarian masses suspected to be endometrioma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269298/
https://www.ncbi.nlm.nih.gov/pubmed/34279456
http://dx.doi.org/10.3390/jcm10132971
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