Cargando…

Metabolic Dynamics in Short- and Long-Term Microgravity in Human Primary Macrophages

Microgravity acts on cellular systems on several levels. Cells of the immune system especially react rapidly to changes in gravity. In this study, we performed a correlative metabolomics analysis on short-term and long-term microgravity effects on primary human macrophages. We could detect an increa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thiel, Cora S., Vahlensieck, Christian, Bradley, Timothy, Tauber, Svantje, Lehmann, Martin, Ullrich, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269311/ https://www.ncbi.nlm.nih.gov/pubmed/34201720 http://dx.doi.org/10.3390/ijms22136752

Ejemplares similares

Cytoskeletal stability and metabolic alterations in primary human macrophages in long-term microgravity
por: Tauber, Svantje, et al.
Publicado: (2017)

Rapid Morphological and Cytoskeletal Response to Microgravity in Human Primary Macrophages
por: Thiel, Cora Sandra, et al.
Publicado: (2019)

Rapid Downregulation of H3K4me3 Binding to Immunoregulatory Genes in Altered Gravity in Primary Human M1 Macrophages
por: Vahlensieck, Christian, et al.
Publicado: (2022)

Rapid adaptation to microgravity in mammalian macrophage cells
por: Thiel, Cora S., et al.
Publicado: (2017)

Transcriptional Homeostasis of Oxidative Stress-Related Pathways in Altered Gravity
por: Tauber, Svantje, et al.
Publicado: (2018)

Rapid Cellular Perception of Gravitational Forces in Human Jurkat T Cells and Transduction into Gene Expression Regulation
por: Thiel, Cora Sandra, et al.
Publicado: (2020)

Regulation of ICAM-1 in Cells of the Monocyte/Macrophage System in Microgravity
por: Paulsen, Katrin, et al.
Publicado: (2015)

Post-Transcriptional Dynamics is Involved in Rapid Adaptation to Hypergravity in Jurkat T Cells
por: Vahlensieck, Christian, et al.
Publicado: (2022)

Expression of Hypoxia-Inducible Factor 1α (HIF-1α) and Genes of Related Pathways in Altered Gravity
por: Vogel, Johannes, et al.
Publicado: (2019)

Rapid alterations of cell cycle control proteins in human T lymphocytes in microgravity
por: Thiel, Cora S, et al.
Publicado: (2012)

Functional Activity of Plasmid DNA after Entry into the Atmosphere of Earth Investigated by a New Biomarker Stability Assay for Ballistic Spaceflight Experiments
por: Thiel, Cora S., et al.
Publicado: (2014)

Gravitational Force—Induced 3D Chromosomal Conformational Changes Are Associated with Rapid Transcriptional Response in Human T Cells
por: Vahlensieck, Christian, et al.
Publicado: (2021)

Transcriptional Response in Human Jurkat T Lymphocytes to a near Physiological Hypergravity Environment and to One Common in Routine Cell Culture Protocols
por: Vahlensieck, Christian, et al.
Publicado: (2023)

Signal transduction in primary human T lymphocytes in altered gravity – results of the MASER-12 suborbital space flight mission
por: Tauber, Svantje, et al.
Publicado: (2013)

Expression of hypoxia-inducible genes is suppressed in altered gravity due to impaired nuclear HIF1α accumulation
por: Aboouf, Mostafa A., et al.
Publicado: (2023)

Rapid Transient Transcriptional Adaptation to Hypergravity in Jurkat T Cells Revealed by Comparative Analysis of Microarray and RNA-Seq Data
por: Vahlensieck, Christian, et al.
Publicado: (2021)

Dynamic gene expression response to altered gravity in human T cells
por: Thiel, Cora S., et al.
Publicado: (2017)

Real-Time 3D High-Resolution Microscopy of Human Cells on the International Space Station
por: Thiel, Cora Sandra, et al.
Publicado: (2019)

Regulation of MMP-9 by a WIN-Binding Site in the Monocyte-Macrophage System Independent from Cannabinoid Receptors
por: Tauber, Svantje, et al.
Publicado: (2012)

The cannabinoid receptors agonist WIN55212-2 inhibits macrophageal differentiation and alters expression and phosphorylation of cell cycle control proteins
por: Paulsen, Katrin, et al.
Publicado: (2011)

Signal transduction in cells of the immune system in microgravity
por: Ullrich, Oliver, et al.
Publicado: (2008)

Stability of gene expression in human T cells in different gravity environments is clustered in chromosomal region 11p15.4
por: Thiel, Cora S., et al.
Publicado: (2017)

Rapid coupling between gravitational forces and the transcriptome in human myelomonocytic U937 cells
por: Thiel, Cora S., et al.
Publicado: (2018)

The Effects of Simulated Microgravity on Macrophage Phenotype
por: Ludtka, Christopher, et al.
Publicado: (2021)

Short-Term Microgravity Influences Cell Adhesion in Human Breast Cancer Cells
por: Nassef, Mohamed Zakaria, et al.
Publicado: (2019)

Macrophages in microgravity: the impact of space on immune cells
por: Ludtka, Christopher, et al.
Publicado: (2021)

The Impacts of Microgravity on Bacterial Metabolism
por: Sharma, Gayatri, et al.
Publicado: (2022)

Identification of Reference Genes in Human Myelomonocytic Cells for Gene Expression Studies in Altered Gravity
por: Thiel, Cora S., et al.
Publicado: (2015)

The effect of long-term exposure to microgravity on the perception of upright
por: Harris, Laurence R., et al.
Publicado: (2017)

Simulated microgravity-mediated reversion of murine lymphoma immune evasion
por: Bradley, Jillian H., et al.
Publicado: (2019)

Human Performance in a Realistic Instrument-Control Task during Short-Term Microgravity
por: Steinberg, Fabian, et al.
Publicado: (2015)

Modelling physiology of haemodynamic adaptation in short-term microgravity exposure and orthostatic stress on Earth
por: Mohammadyari, Parvin, et al.
Publicado: (2021)

Long-term exposure to microgravity impairs vestibulo-cardiovascular reflex
por: Morita, Hironobu, et al.
Publicado: (2016)

Cartilage breakdown in microgravity—a problem for long-term spaceflight?
por: Fitzgerald, Jamie
Publicado: (2017)

Microgravity and Hypergravity Induced by Parabolic Flight Differently Affect Lumbar Spinal Stiffness
por: Swanenburg, Jaap, et al.
Publicado: (2020)

Morphological and Physiological Changes in Mature In Vitro Neuronal Networks towards Exposure to Short-, Middle- or Long-Term Simulated Microgravity
por: Pani, Giuseppe, et al.
Publicado: (2013)

Dynamics of entomopathogenic nematode foraging and infectivity in microgravity
por: Kaplan, Fatma, et al.
Publicado: (2020)

Altered Regional Homogeneity with Short-term Simulated Microgravity and Its Relationship with Changed Performance in Mental Transformation
por: Liao, Yang, et al.
Publicado: (2013)

Decreased biofilm formation in Proteus mirabilis after short-term exposure to a simulated microgravity environment
por: Wang, Dapeng, et al.
Publicado: (2021)

Adaptation of Mouse Skeletal Muscle to Long-Term Microgravity in the MDS Mission
por: Sandonà, Dorianna, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_hsl6ke0o7u83rrre8da97unb5o