Cargando…

Nutraceutical and Probiotic Approaches to Examine Molecular Interactions of the Amyloid Precursor Protein APP in Drosophila Models of Alzheimer’s Disease

Studies using animal models have shed light into the molecular and cellular basis for the neuropathology observed in patients with Alzheimer’s disease (AD). In particular, the role of the amyloid precursor protein (APP) plays a crucial role in the formation of senile plaques and aging-dependent dege...

Descripción completa

Detalles Bibliográficos
Autores principales: Jalali, David, Guevarra, Justine Anne, Martinez, Luz, Hung, Lily, Vonhoff, Fernando J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269328/
https://www.ncbi.nlm.nih.gov/pubmed/34209883
http://dx.doi.org/10.3390/ijms22137022
_version_ 1783720554890526720
author Jalali, David
Guevarra, Justine Anne
Martinez, Luz
Hung, Lily
Vonhoff, Fernando J
author_facet Jalali, David
Guevarra, Justine Anne
Martinez, Luz
Hung, Lily
Vonhoff, Fernando J
author_sort Jalali, David
collection PubMed
description Studies using animal models have shed light into the molecular and cellular basis for the neuropathology observed in patients with Alzheimer’s disease (AD). In particular, the role of the amyloid precursor protein (APP) plays a crucial role in the formation of senile plaques and aging-dependent degeneration. Here, we focus our review on recent findings using the Drosophila AD model to expand our understanding of APP molecular function and interactions, including insights gained from the fly homolog APP-like (APPL). Finally, as there is still no cure for AD, we review some approaches that have shown promising results in ameliorating AD-associated phenotypes, with special attention on the use of nutraceuticals and their molecular effects, as well as interactions with the gut microbiome. Overall, the phenomena described here are of fundamental significance for understanding network development and degeneration. Given the highly conserved nature of fundamental signaling pathways, the insight gained from animal models such as Drosophila melanogaster will likely advance the understanding of the mammalian brain, and thus be relevant to human health.
format Online
Article
Text
id pubmed-8269328
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-82693282021-07-10 Nutraceutical and Probiotic Approaches to Examine Molecular Interactions of the Amyloid Precursor Protein APP in Drosophila Models of Alzheimer’s Disease Jalali, David Guevarra, Justine Anne Martinez, Luz Hung, Lily Vonhoff, Fernando J Int J Mol Sci Review Studies using animal models have shed light into the molecular and cellular basis for the neuropathology observed in patients with Alzheimer’s disease (AD). In particular, the role of the amyloid precursor protein (APP) plays a crucial role in the formation of senile plaques and aging-dependent degeneration. Here, we focus our review on recent findings using the Drosophila AD model to expand our understanding of APP molecular function and interactions, including insights gained from the fly homolog APP-like (APPL). Finally, as there is still no cure for AD, we review some approaches that have shown promising results in ameliorating AD-associated phenotypes, with special attention on the use of nutraceuticals and their molecular effects, as well as interactions with the gut microbiome. Overall, the phenomena described here are of fundamental significance for understanding network development and degeneration. Given the highly conserved nature of fundamental signaling pathways, the insight gained from animal models such as Drosophila melanogaster will likely advance the understanding of the mammalian brain, and thus be relevant to human health. MDPI 2021-06-29 /pmc/articles/PMC8269328/ /pubmed/34209883 http://dx.doi.org/10.3390/ijms22137022 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jalali, David
Guevarra, Justine Anne
Martinez, Luz
Hung, Lily
Vonhoff, Fernando J
Nutraceutical and Probiotic Approaches to Examine Molecular Interactions of the Amyloid Precursor Protein APP in Drosophila Models of Alzheimer’s Disease
title Nutraceutical and Probiotic Approaches to Examine Molecular Interactions of the Amyloid Precursor Protein APP in Drosophila Models of Alzheimer’s Disease
title_full Nutraceutical and Probiotic Approaches to Examine Molecular Interactions of the Amyloid Precursor Protein APP in Drosophila Models of Alzheimer’s Disease
title_fullStr Nutraceutical and Probiotic Approaches to Examine Molecular Interactions of the Amyloid Precursor Protein APP in Drosophila Models of Alzheimer’s Disease
title_full_unstemmed Nutraceutical and Probiotic Approaches to Examine Molecular Interactions of the Amyloid Precursor Protein APP in Drosophila Models of Alzheimer’s Disease
title_short Nutraceutical and Probiotic Approaches to Examine Molecular Interactions of the Amyloid Precursor Protein APP in Drosophila Models of Alzheimer’s Disease
title_sort nutraceutical and probiotic approaches to examine molecular interactions of the amyloid precursor protein app in drosophila models of alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269328/
https://www.ncbi.nlm.nih.gov/pubmed/34209883
http://dx.doi.org/10.3390/ijms22137022
work_keys_str_mv AT jalalidavid nutraceuticalandprobioticapproachestoexaminemolecularinteractionsoftheamyloidprecursorproteinappindrosophilamodelsofalzheimersdisease
AT guevarrajustineanne nutraceuticalandprobioticapproachestoexaminemolecularinteractionsoftheamyloidprecursorproteinappindrosophilamodelsofalzheimersdisease
AT martinezluz nutraceuticalandprobioticapproachestoexaminemolecularinteractionsoftheamyloidprecursorproteinappindrosophilamodelsofalzheimersdisease
AT hunglily nutraceuticalandprobioticapproachestoexaminemolecularinteractionsoftheamyloidprecursorproteinappindrosophilamodelsofalzheimersdisease
AT vonhofffernandoj nutraceuticalandprobioticapproachestoexaminemolecularinteractionsoftheamyloidprecursorproteinappindrosophilamodelsofalzheimersdisease