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COVID-19 and the Endocrine System: A Comprehensive Review on the Theme

Background and aim. The review aimed to summarize advances in the topic of endocrine diseases and coronavirus disease 2019 (COVID-19). Methods. Scientific and institutional websites and databases were searched and data were collected and organized, when plausible, to angle the discussion toward the...

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Autores principales: Lisco, Giuseppe, De Tullio, Anna, Stragapede, Assunta, Solimando, Antonio Giovanni, Albanese, Federica, Capobianco, Martina, Giagulli, Vito Angelo, Guastamacchia, Edoardo, De Pergola, Giovanni, Vacca, Angelo, Racanelli, Vito, Triggiani, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269331/
https://www.ncbi.nlm.nih.gov/pubmed/34209964
http://dx.doi.org/10.3390/jcm10132920
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author Lisco, Giuseppe
De Tullio, Anna
Stragapede, Assunta
Solimando, Antonio Giovanni
Albanese, Federica
Capobianco, Martina
Giagulli, Vito Angelo
Guastamacchia, Edoardo
De Pergola, Giovanni
Vacca, Angelo
Racanelli, Vito
Triggiani, Vincenzo
author_facet Lisco, Giuseppe
De Tullio, Anna
Stragapede, Assunta
Solimando, Antonio Giovanni
Albanese, Federica
Capobianco, Martina
Giagulli, Vito Angelo
Guastamacchia, Edoardo
De Pergola, Giovanni
Vacca, Angelo
Racanelli, Vito
Triggiani, Vincenzo
author_sort Lisco, Giuseppe
collection PubMed
description Background and aim. The review aimed to summarize advances in the topic of endocrine diseases and coronavirus disease 2019 (COVID-19). Methods. Scientific and institutional websites and databases were searched and data were collected and organized, when plausible, to angle the discussion toward the following clinical issues. (1) Are patients with COVID-19 at higher risk of developing acute or late-onset endocrine diseases or dysfunction? (2) May the underlying endocrine diseases or dysfunctions be considered risk factors for poor prognosis once the infection has occurred? (3) Are there defined strategies to manage endocrine diseases despite pandemic-related constraints? Herein, the authors considered only relevant and more frequently observed endocrine diseases and disorders related to the hypothalamic-pituitary region, thyroid and parathyroid glands, calcium-phosphorus homeostasis and osteoporosis, adrenal glands, and gonads. Main. Data highlight the basis of some pathophysiological mechanisms and anatomical alterations of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-induced endocrine dysfunctions. Some conditions, such as adrenal insufficiency and cortisol excess, may be risk factors of worse clinical progression once the infection has occurred. These at-risk populations may require adequate education to avoid the SARS-CoV-2 infection and adequately manage medical therapy during the pandemic, even in emergencies. Endocrine disease management underwent a palpable restraint, especially procedures requiring obligate access to healthcare facilities for diagnostic and therapeutic purposes. Strategies of clinical triage to prioritize medical consultations, laboratory, instrumental evaluations, and digital telehealth solutions should be implemented to better deal with this probably long-term situation.
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spelling pubmed-82693312021-07-10 COVID-19 and the Endocrine System: A Comprehensive Review on the Theme Lisco, Giuseppe De Tullio, Anna Stragapede, Assunta Solimando, Antonio Giovanni Albanese, Federica Capobianco, Martina Giagulli, Vito Angelo Guastamacchia, Edoardo De Pergola, Giovanni Vacca, Angelo Racanelli, Vito Triggiani, Vincenzo J Clin Med Review Background and aim. The review aimed to summarize advances in the topic of endocrine diseases and coronavirus disease 2019 (COVID-19). Methods. Scientific and institutional websites and databases were searched and data were collected and organized, when plausible, to angle the discussion toward the following clinical issues. (1) Are patients with COVID-19 at higher risk of developing acute or late-onset endocrine diseases or dysfunction? (2) May the underlying endocrine diseases or dysfunctions be considered risk factors for poor prognosis once the infection has occurred? (3) Are there defined strategies to manage endocrine diseases despite pandemic-related constraints? Herein, the authors considered only relevant and more frequently observed endocrine diseases and disorders related to the hypothalamic-pituitary region, thyroid and parathyroid glands, calcium-phosphorus homeostasis and osteoporosis, adrenal glands, and gonads. Main. Data highlight the basis of some pathophysiological mechanisms and anatomical alterations of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-induced endocrine dysfunctions. Some conditions, such as adrenal insufficiency and cortisol excess, may be risk factors of worse clinical progression once the infection has occurred. These at-risk populations may require adequate education to avoid the SARS-CoV-2 infection and adequately manage medical therapy during the pandemic, even in emergencies. Endocrine disease management underwent a palpable restraint, especially procedures requiring obligate access to healthcare facilities for diagnostic and therapeutic purposes. Strategies of clinical triage to prioritize medical consultations, laboratory, instrumental evaluations, and digital telehealth solutions should be implemented to better deal with this probably long-term situation. MDPI 2021-06-29 /pmc/articles/PMC8269331/ /pubmed/34209964 http://dx.doi.org/10.3390/jcm10132920 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lisco, Giuseppe
De Tullio, Anna
Stragapede, Assunta
Solimando, Antonio Giovanni
Albanese, Federica
Capobianco, Martina
Giagulli, Vito Angelo
Guastamacchia, Edoardo
De Pergola, Giovanni
Vacca, Angelo
Racanelli, Vito
Triggiani, Vincenzo
COVID-19 and the Endocrine System: A Comprehensive Review on the Theme
title COVID-19 and the Endocrine System: A Comprehensive Review on the Theme
title_full COVID-19 and the Endocrine System: A Comprehensive Review on the Theme
title_fullStr COVID-19 and the Endocrine System: A Comprehensive Review on the Theme
title_full_unstemmed COVID-19 and the Endocrine System: A Comprehensive Review on the Theme
title_short COVID-19 and the Endocrine System: A Comprehensive Review on the Theme
title_sort covid-19 and the endocrine system: a comprehensive review on the theme
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269331/
https://www.ncbi.nlm.nih.gov/pubmed/34209964
http://dx.doi.org/10.3390/jcm10132920
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