Characterization of an Atypical Trypanosoma brucei Hsp70 Demonstrates Its Cytosolic-Nuclear Localization and Modulation by Quercetin and Methylene Blue

Trypanosoma brucei (Tb) harbours twelve Hsp70 chaperones. Of these, four are predicted to reside in the parasite cytosol. TbHsp70.c is predicted to be cytosolic and upregulated upon heat stress and is an ATPase that exhibits holdase chaperone function. Cytosol-localized Tbj2 stimulates the ATPase ac...

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Detalles Bibliográficos
Autores principales: Burger, Adélle, Macucule-Tinga, Paula, Bentley, Stephen John, Ludewig, Michael Hans, Mhlongo, Ndumiso Nhlakanipho, Shonhai, Addmore, Boshoff, Aileen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269394/
https://www.ncbi.nlm.nih.gov/pubmed/34202520
http://dx.doi.org/10.3390/ijms22136776

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