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Experimental and Numerical Simulations of 3D-Printed Polycaprolactone Scaffolds for Bone Tissue Engineering Applications

Ideal bone scaffolds for tissue engineering should be highly porous allowing cell attachment, spreading, and differentiation and presenting appropriate biomechanical properties. These antagonistic characteristics usually require extensive experimental work to achieve optimised balanced properties. T...

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Detalles Bibliográficos
Autores principales: Xu, Zhanyan, Omar, Abdalla M., Bartolo, Paulo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269492/
https://www.ncbi.nlm.nih.gov/pubmed/34201996
http://dx.doi.org/10.3390/ma14133546
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author Xu, Zhanyan
Omar, Abdalla M.
Bartolo, Paulo
author_facet Xu, Zhanyan
Omar, Abdalla M.
Bartolo, Paulo
author_sort Xu, Zhanyan
collection PubMed
description Ideal bone scaffolds for tissue engineering should be highly porous allowing cell attachment, spreading, and differentiation and presenting appropriate biomechanical properties. These antagonistic characteristics usually require extensive experimental work to achieve optimised balanced properties. This paper presents a simulation approach to determine the mechanical behaviour of bone scaffolds allowing the compressive modulus and the deformation mechanisms to be predicted. Polycaprolactone scaffolds with regular square pores and different porosities were considered. Scaffolds were also printed using an extrusion-based additive manufacturing and assessed under compressive loads. Similar designs were used for both simulation and fabrication steps. A good correlation between numerical and experimental results was obtained, highlighting the suitability of the simulation tool for the mechanical design of 3D-printed bone scaffolds.
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spelling pubmed-82694922021-07-10 Experimental and Numerical Simulations of 3D-Printed Polycaprolactone Scaffolds for Bone Tissue Engineering Applications Xu, Zhanyan Omar, Abdalla M. Bartolo, Paulo Materials (Basel) Article Ideal bone scaffolds for tissue engineering should be highly porous allowing cell attachment, spreading, and differentiation and presenting appropriate biomechanical properties. These antagonistic characteristics usually require extensive experimental work to achieve optimised balanced properties. This paper presents a simulation approach to determine the mechanical behaviour of bone scaffolds allowing the compressive modulus and the deformation mechanisms to be predicted. Polycaprolactone scaffolds with regular square pores and different porosities were considered. Scaffolds were also printed using an extrusion-based additive manufacturing and assessed under compressive loads. Similar designs were used for both simulation and fabrication steps. A good correlation between numerical and experimental results was obtained, highlighting the suitability of the simulation tool for the mechanical design of 3D-printed bone scaffolds. MDPI 2021-06-25 /pmc/articles/PMC8269492/ /pubmed/34201996 http://dx.doi.org/10.3390/ma14133546 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xu, Zhanyan
Omar, Abdalla M.
Bartolo, Paulo
Experimental and Numerical Simulations of 3D-Printed Polycaprolactone Scaffolds for Bone Tissue Engineering Applications
title Experimental and Numerical Simulations of 3D-Printed Polycaprolactone Scaffolds for Bone Tissue Engineering Applications
title_full Experimental and Numerical Simulations of 3D-Printed Polycaprolactone Scaffolds for Bone Tissue Engineering Applications
title_fullStr Experimental and Numerical Simulations of 3D-Printed Polycaprolactone Scaffolds for Bone Tissue Engineering Applications
title_full_unstemmed Experimental and Numerical Simulations of 3D-Printed Polycaprolactone Scaffolds for Bone Tissue Engineering Applications
title_short Experimental and Numerical Simulations of 3D-Printed Polycaprolactone Scaffolds for Bone Tissue Engineering Applications
title_sort experimental and numerical simulations of 3d-printed polycaprolactone scaffolds for bone tissue engineering applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269492/
https://www.ncbi.nlm.nih.gov/pubmed/34201996
http://dx.doi.org/10.3390/ma14133546
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AT bartolopaulo experimentalandnumericalsimulationsof3dprintedpolycaprolactonescaffoldsforbonetissueengineeringapplications