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Bone Morphogenetic Proteins, Carriers, and Animal Models in the Development of Novel Bone Regenerative Therapies

Bone morphogenetic proteins (BMPs) possess a unique ability to induce new bone formation. Numerous preclinical studies have been conducted to develop novel, BMP-based osteoinductive devices for the management of segmental bone defects and posterolateral spinal fusion (PLF). In these studies, BMPs we...

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Autores principales: Stokovic, Nikola, Ivanjko, Natalia, Maticic, Drazen, Luyten, Frank P., Vukicevic, Slobodan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269575/
https://www.ncbi.nlm.nih.gov/pubmed/34202501
http://dx.doi.org/10.3390/ma14133513
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author Stokovic, Nikola
Ivanjko, Natalia
Maticic, Drazen
Luyten, Frank P.
Vukicevic, Slobodan
author_facet Stokovic, Nikola
Ivanjko, Natalia
Maticic, Drazen
Luyten, Frank P.
Vukicevic, Slobodan
author_sort Stokovic, Nikola
collection PubMed
description Bone morphogenetic proteins (BMPs) possess a unique ability to induce new bone formation. Numerous preclinical studies have been conducted to develop novel, BMP-based osteoinductive devices for the management of segmental bone defects and posterolateral spinal fusion (PLF). In these studies, BMPs were combined with a broad range of carriers (natural and synthetic polymers, inorganic materials, and their combinations) and tested in various models in mice, rats, rabbits, dogs, sheep, and non-human primates. In this review, we summarized bone regeneration strategies and animal models used for the initial, intermediate, and advanced evaluation of promising therapeutical solutions for new bone formation and repair. Moreover, in this review, we discuss basic aspects to be considered when planning animal experiments, including anatomical characteristics of the species used, appropriate BMP dosing, duration of the observation period, and sample size.
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spelling pubmed-82695752021-07-10 Bone Morphogenetic Proteins, Carriers, and Animal Models in the Development of Novel Bone Regenerative Therapies Stokovic, Nikola Ivanjko, Natalia Maticic, Drazen Luyten, Frank P. Vukicevic, Slobodan Materials (Basel) Review Bone morphogenetic proteins (BMPs) possess a unique ability to induce new bone formation. Numerous preclinical studies have been conducted to develop novel, BMP-based osteoinductive devices for the management of segmental bone defects and posterolateral spinal fusion (PLF). In these studies, BMPs were combined with a broad range of carriers (natural and synthetic polymers, inorganic materials, and their combinations) and tested in various models in mice, rats, rabbits, dogs, sheep, and non-human primates. In this review, we summarized bone regeneration strategies and animal models used for the initial, intermediate, and advanced evaluation of promising therapeutical solutions for new bone formation and repair. Moreover, in this review, we discuss basic aspects to be considered when planning animal experiments, including anatomical characteristics of the species used, appropriate BMP dosing, duration of the observation period, and sample size. MDPI 2021-06-24 /pmc/articles/PMC8269575/ /pubmed/34202501 http://dx.doi.org/10.3390/ma14133513 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Stokovic, Nikola
Ivanjko, Natalia
Maticic, Drazen
Luyten, Frank P.
Vukicevic, Slobodan
Bone Morphogenetic Proteins, Carriers, and Animal Models in the Development of Novel Bone Regenerative Therapies
title Bone Morphogenetic Proteins, Carriers, and Animal Models in the Development of Novel Bone Regenerative Therapies
title_full Bone Morphogenetic Proteins, Carriers, and Animal Models in the Development of Novel Bone Regenerative Therapies
title_fullStr Bone Morphogenetic Proteins, Carriers, and Animal Models in the Development of Novel Bone Regenerative Therapies
title_full_unstemmed Bone Morphogenetic Proteins, Carriers, and Animal Models in the Development of Novel Bone Regenerative Therapies
title_short Bone Morphogenetic Proteins, Carriers, and Animal Models in the Development of Novel Bone Regenerative Therapies
title_sort bone morphogenetic proteins, carriers, and animal models in the development of novel bone regenerative therapies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269575/
https://www.ncbi.nlm.nih.gov/pubmed/34202501
http://dx.doi.org/10.3390/ma14133513
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