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Cerebroprotein hydrolysate‐I protects senescence‐induced by D‐galactose in PC12 cells and mice

Cerebroprotein hydrolysate‐I (CH‐I),a mixture of peptides extracted from porcine brain tissue,has shown a neuroprotective effect, but its role in brain senescence is unclear. In the present study, we established a senescence model of PC12 cells and mice to investigate the effect of CH‐I on brain sen...

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Autores principales: Zhu, Lin, Liu, Yingjuan, Wu, Xiaolin, Ren, Yuqian, Zhang, Qinghua, Ren, Leiming, Guo, Yunliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269606/
https://www.ncbi.nlm.nih.gov/pubmed/34262731
http://dx.doi.org/10.1002/fsn3.2333
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author Zhu, Lin
Liu, Yingjuan
Wu, Xiaolin
Ren, Yuqian
Zhang, Qinghua
Ren, Leiming
Guo, Yunliang
author_facet Zhu, Lin
Liu, Yingjuan
Wu, Xiaolin
Ren, Yuqian
Zhang, Qinghua
Ren, Leiming
Guo, Yunliang
author_sort Zhu, Lin
collection PubMed
description Cerebroprotein hydrolysate‐I (CH‐I),a mixture of peptides extracted from porcine brain tissue,has shown a neuroprotective effect, but its role in brain senescence is unclear. In the present study, we established a senescence model of PC12 cells and mice to investigate the effect of CH‐I on brain senescence via JAK2/STAT3 pathway. The results showed that CH‐I could improve cell viability, inhibit the apoptosis of cells, and reduce the senescence‐positive cells induced by D‐galactose. In vivo, CH‐I improved the learning ability and memory of aging mice, reduced neuronal damage in mice hippocampus. Mechanism studies showed that CH‐I could adjust BDNF protein expressions, activate JAK2/STAT3 pathway, and finally enhance telomerase activity. All these findings indicated that CH‐I showed a neuroprotective effect against brain senescence. These results might provide further reference and support for the application of CH‐I in delaying aging.
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spelling pubmed-82696062021-07-13 Cerebroprotein hydrolysate‐I protects senescence‐induced by D‐galactose in PC12 cells and mice Zhu, Lin Liu, Yingjuan Wu, Xiaolin Ren, Yuqian Zhang, Qinghua Ren, Leiming Guo, Yunliang Food Sci Nutr Original Research Cerebroprotein hydrolysate‐I (CH‐I),a mixture of peptides extracted from porcine brain tissue,has shown a neuroprotective effect, but its role in brain senescence is unclear. In the present study, we established a senescence model of PC12 cells and mice to investigate the effect of CH‐I on brain senescence via JAK2/STAT3 pathway. The results showed that CH‐I could improve cell viability, inhibit the apoptosis of cells, and reduce the senescence‐positive cells induced by D‐galactose. In vivo, CH‐I improved the learning ability and memory of aging mice, reduced neuronal damage in mice hippocampus. Mechanism studies showed that CH‐I could adjust BDNF protein expressions, activate JAK2/STAT3 pathway, and finally enhance telomerase activity. All these findings indicated that CH‐I showed a neuroprotective effect against brain senescence. These results might provide further reference and support for the application of CH‐I in delaying aging. John Wiley and Sons Inc. 2021-05-17 /pmc/articles/PMC8269606/ /pubmed/34262731 http://dx.doi.org/10.1002/fsn3.2333 Text en © 2021 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Zhu, Lin
Liu, Yingjuan
Wu, Xiaolin
Ren, Yuqian
Zhang, Qinghua
Ren, Leiming
Guo, Yunliang
Cerebroprotein hydrolysate‐I protects senescence‐induced by D‐galactose in PC12 cells and mice
title Cerebroprotein hydrolysate‐I protects senescence‐induced by D‐galactose in PC12 cells and mice
title_full Cerebroprotein hydrolysate‐I protects senescence‐induced by D‐galactose in PC12 cells and mice
title_fullStr Cerebroprotein hydrolysate‐I protects senescence‐induced by D‐galactose in PC12 cells and mice
title_full_unstemmed Cerebroprotein hydrolysate‐I protects senescence‐induced by D‐galactose in PC12 cells and mice
title_short Cerebroprotein hydrolysate‐I protects senescence‐induced by D‐galactose in PC12 cells and mice
title_sort cerebroprotein hydrolysate‐i protects senescence‐induced by d‐galactose in pc12 cells and mice
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269606/
https://www.ncbi.nlm.nih.gov/pubmed/34262731
http://dx.doi.org/10.1002/fsn3.2333
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