In vitro antioxidant and antitumor study of zein/SHA nanoparticles loaded with resveratrol

Resveratrol (RES) loaded Zein‐SHA (low‐molecular‐weight sodium hyaluronate) nanoparticles with average diameter of about 152.13 nm and polydispersity index (PDI) of 0.122, which can be used to encapsulate, protect and deliver resveratrol. By measuring ABTS free radical scavenging ability and iron (I...

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Detalles Bibliográficos
Autores principales: Shi, Qiankun, Wang, Xinya, Tang, Xudong, Zhen, Nuo, Wang, Yupeng, Luo, Zhijian, Zhang, Hao, Liu, Jingsheng, Zhou, Dongfang, Huang, Keke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269682/
https://www.ncbi.nlm.nih.gov/pubmed/34262713
http://dx.doi.org/10.1002/fsn3.2302
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author Shi, Qiankun
Wang, Xinya
Tang, Xudong
Zhen, Nuo
Wang, Yupeng
Luo, Zhijian
Zhang, Hao
Liu, Jingsheng
Zhou, Dongfang
Huang, Keke
author_facet Shi, Qiankun
Wang, Xinya
Tang, Xudong
Zhen, Nuo
Wang, Yupeng
Luo, Zhijian
Zhang, Hao
Liu, Jingsheng
Zhou, Dongfang
Huang, Keke
author_sort Shi, Qiankun
collection PubMed
description Resveratrol (RES) loaded Zein‐SHA (low‐molecular‐weight sodium hyaluronate) nanoparticles with average diameter of about 152.13 nm and polydispersity index (PDI) of 0.122, which can be used to encapsulate, protect and deliver resveratrol. By measuring ABTS free radical scavenging ability and iron (III) reducing power, it was determined that encapsulated resveratrol has higher in vitro antioxidant activity than free resveratrol. When tested with murine breast cancer cells 4T1, the encapsulated resveratrol also showed higher antiproliferative activity than free resveratrol, with IC(50) values of 14.73 and 17.84 μg/ml, respectively. The colloidal form of resveratrol developed in this research may be particularly suitable for functional foods and beverages, as well as dietary supplements and pharmaceutical products.
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spelling pubmed-82696822021-07-13 In vitro antioxidant and antitumor study of zein/SHA nanoparticles loaded with resveratrol Shi, Qiankun Wang, Xinya Tang, Xudong Zhen, Nuo Wang, Yupeng Luo, Zhijian Zhang, Hao Liu, Jingsheng Zhou, Dongfang Huang, Keke Food Sci Nutr Original Research Resveratrol (RES) loaded Zein‐SHA (low‐molecular‐weight sodium hyaluronate) nanoparticles with average diameter of about 152.13 nm and polydispersity index (PDI) of 0.122, which can be used to encapsulate, protect and deliver resveratrol. By measuring ABTS free radical scavenging ability and iron (III) reducing power, it was determined that encapsulated resveratrol has higher in vitro antioxidant activity than free resveratrol. When tested with murine breast cancer cells 4T1, the encapsulated resveratrol also showed higher antiproliferative activity than free resveratrol, with IC(50) values of 14.73 and 17.84 μg/ml, respectively. The colloidal form of resveratrol developed in this research may be particularly suitable for functional foods and beverages, as well as dietary supplements and pharmaceutical products. John Wiley and Sons Inc. 2021-05-07 /pmc/articles/PMC8269682/ /pubmed/34262713 http://dx.doi.org/10.1002/fsn3.2302 Text en © 2021 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Shi, Qiankun
Wang, Xinya
Tang, Xudong
Zhen, Nuo
Wang, Yupeng
Luo, Zhijian
Zhang, Hao
Liu, Jingsheng
Zhou, Dongfang
Huang, Keke
In vitro antioxidant and antitumor study of zein/SHA nanoparticles loaded with resveratrol
title In vitro antioxidant and antitumor study of zein/SHA nanoparticles loaded with resveratrol
title_full In vitro antioxidant and antitumor study of zein/SHA nanoparticles loaded with resveratrol
title_fullStr In vitro antioxidant and antitumor study of zein/SHA nanoparticles loaded with resveratrol
title_full_unstemmed In vitro antioxidant and antitumor study of zein/SHA nanoparticles loaded with resveratrol
title_short In vitro antioxidant and antitumor study of zein/SHA nanoparticles loaded with resveratrol
title_sort in vitro antioxidant and antitumor study of zein/sha nanoparticles loaded with resveratrol
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269682/
https://www.ncbi.nlm.nih.gov/pubmed/34262713
http://dx.doi.org/10.1002/fsn3.2302
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