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Optimized TrkB Agonist Ameliorates Alzheimer’s Disease Pathologies and Improves Cognitive Functions via Inhibiting Delta-Secretase

[Image: see text] BDNF/TrkB neurotropic pathway, essential for neural synaptic plasticity and survival, is deficient in neurodegenerative diseases including Alzheimer’s disease (AD). Our previous works support that BDNF diminishes AD pathologies by inhibiting delta-secretase, a crucial age-dependent...

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Detalles Bibliográficos
Autores principales:	Chen, Chun, Ahn, Eun H., Liu, Xia, Wang, Zhi-Hao, Luo, Shilin, Liao, Jianming, Ye, Keqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269693/ https://www.ncbi.nlm.nih.gov/pubmed/34106682 http://dx.doi.org/10.1021/acschemneuro.1c00181

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