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Determination of Child Waist Circumference Cut Points for Metabolic Risk Based on Acanthosis Nigricans, the Children’s Healthy Living Program

INTRODUCTION: Waist circumference is a common anthropometric measure for predicting abdominal obesity and insulin resistance. We developed optimal waist circumference cut points for children aged 2 to 8 years in the US-Affiliated Pacific (USAP) region based on the relationship of waist circumference...

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Autores principales: Yamanaka, Ashley B., Davis, James D., Wilkens, Lynne R., Hurwitz, Eric L., Fialkowski, Marie K., Deenik, Jonathan, Leon Guerrero, Rachael T., Novotny, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269744/
https://www.ncbi.nlm.nih.gov/pubmed/34166179
http://dx.doi.org/10.5888/pcd18.210021
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author Yamanaka, Ashley B.
Davis, James D.
Wilkens, Lynne R.
Hurwitz, Eric L.
Fialkowski, Marie K.
Deenik, Jonathan
Leon Guerrero, Rachael T.
Novotny, Rachel
author_facet Yamanaka, Ashley B.
Davis, James D.
Wilkens, Lynne R.
Hurwitz, Eric L.
Fialkowski, Marie K.
Deenik, Jonathan
Leon Guerrero, Rachael T.
Novotny, Rachel
author_sort Yamanaka, Ashley B.
collection PubMed
description INTRODUCTION: Waist circumference is a common anthropometric measure for predicting abdominal obesity and insulin resistance. We developed optimal waist circumference cut points for children aged 2 to 8 years in the US-Affiliated Pacific (USAP) region based on the relationship of waist circumference and acanthosis nigricans in this population. METHODS: We conducted a cross-sectional analysis from the Children’s Healthy Living Program’s 2012–2013 data on 4,023 children. We used receiver-operating characteristic analysis to determine the sensitivity and specificity for acanthosis nigricans across waist circumference, by sex and age. We determined optimal waist circumference cutoff points corresponding to Youden index (J), (equal to [sensitivity + specificity] – 1), with acanthosis nigricans. We compared these cut points with the 90th percentile. RESULTS: The 90th-percentile cut points for boys aged 2 to 5 years (58.15 cm) and 6 to 8 years (71.63 cm) were slightly higher than for girls in both age groups (aged 2–5 y, 57.97 cm; 6–8 y: 70.37 cm). The optimal cut points (corresponding to the highest sensitivity and specificity) were as follows: for boys aged 2 to 5 years, 90th percentile (58.25 cm; sensitivity, 48.0%; specificity, 91.5%); for boys aged 6 to 8 years, 78th percentile (63.59 cm; sensitivity, 86.8%; specificity, 82.8%); for girls aged 2 to 5 years, 62nd percentile (53.27 cm; sensitivity, 71.4%; specificity, 63.1%), and for girls aged 6 to 8 years, 80th percentile (63.63 cm; sensitivity, 55.4%; specificity, 82.9%). CONCLUSION: Among USAP children, waist circumference was a reasonable predictor for acanthosis nigricans. Further analysis is warranted to examine causes of acanthosis nigricans at lower-than-expected waist circumference percentiles. The cut points can be used for early detection of metabolic risk.
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spelling pubmed-82697442021-07-20 Determination of Child Waist Circumference Cut Points for Metabolic Risk Based on Acanthosis Nigricans, the Children’s Healthy Living Program Yamanaka, Ashley B. Davis, James D. Wilkens, Lynne R. Hurwitz, Eric L. Fialkowski, Marie K. Deenik, Jonathan Leon Guerrero, Rachael T. Novotny, Rachel Prev Chronic Dis Original Research INTRODUCTION: Waist circumference is a common anthropometric measure for predicting abdominal obesity and insulin resistance. We developed optimal waist circumference cut points for children aged 2 to 8 years in the US-Affiliated Pacific (USAP) region based on the relationship of waist circumference and acanthosis nigricans in this population. METHODS: We conducted a cross-sectional analysis from the Children’s Healthy Living Program’s 2012–2013 data on 4,023 children. We used receiver-operating characteristic analysis to determine the sensitivity and specificity for acanthosis nigricans across waist circumference, by sex and age. We determined optimal waist circumference cutoff points corresponding to Youden index (J), (equal to [sensitivity + specificity] – 1), with acanthosis nigricans. We compared these cut points with the 90th percentile. RESULTS: The 90th-percentile cut points for boys aged 2 to 5 years (58.15 cm) and 6 to 8 years (71.63 cm) were slightly higher than for girls in both age groups (aged 2–5 y, 57.97 cm; 6–8 y: 70.37 cm). The optimal cut points (corresponding to the highest sensitivity and specificity) were as follows: for boys aged 2 to 5 years, 90th percentile (58.25 cm; sensitivity, 48.0%; specificity, 91.5%); for boys aged 6 to 8 years, 78th percentile (63.59 cm; sensitivity, 86.8%; specificity, 82.8%); for girls aged 2 to 5 years, 62nd percentile (53.27 cm; sensitivity, 71.4%; specificity, 63.1%), and for girls aged 6 to 8 years, 80th percentile (63.63 cm; sensitivity, 55.4%; specificity, 82.9%). CONCLUSION: Among USAP children, waist circumference was a reasonable predictor for acanthosis nigricans. Further analysis is warranted to examine causes of acanthosis nigricans at lower-than-expected waist circumference percentiles. The cut points can be used for early detection of metabolic risk. Centers for Disease Control and Prevention 2021-06-24 /pmc/articles/PMC8269744/ /pubmed/34166179 http://dx.doi.org/10.5888/pcd18.210021 Text en https://creativecommons.org/licenses/by/4.0/Preventing Chronic Disease is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Original Research
Yamanaka, Ashley B.
Davis, James D.
Wilkens, Lynne R.
Hurwitz, Eric L.
Fialkowski, Marie K.
Deenik, Jonathan
Leon Guerrero, Rachael T.
Novotny, Rachel
Determination of Child Waist Circumference Cut Points for Metabolic Risk Based on Acanthosis Nigricans, the Children’s Healthy Living Program
title Determination of Child Waist Circumference Cut Points for Metabolic Risk Based on Acanthosis Nigricans, the Children’s Healthy Living Program
title_full Determination of Child Waist Circumference Cut Points for Metabolic Risk Based on Acanthosis Nigricans, the Children’s Healthy Living Program
title_fullStr Determination of Child Waist Circumference Cut Points for Metabolic Risk Based on Acanthosis Nigricans, the Children’s Healthy Living Program
title_full_unstemmed Determination of Child Waist Circumference Cut Points for Metabolic Risk Based on Acanthosis Nigricans, the Children’s Healthy Living Program
title_short Determination of Child Waist Circumference Cut Points for Metabolic Risk Based on Acanthosis Nigricans, the Children’s Healthy Living Program
title_sort determination of child waist circumference cut points for metabolic risk based on acanthosis nigricans, the children’s healthy living program
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269744/
https://www.ncbi.nlm.nih.gov/pubmed/34166179
http://dx.doi.org/10.5888/pcd18.210021
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