Microbiome in Rheumatoid Arthritis and Celiac Disease: A Friend or Foe

Rheumatoid arthritis (RA) and celiac disease (CD) are both autoimmune diseases with increasing global prevalence. These two diseases have been connected based on similar HLA mutations, serological markers, rheumatological, and gastrointestinal manifestations. In this review, we discuss the role of t...

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Autores principales: Elsouri, Kawther, Arboleda, Vania, Heiser, Samantha, Kesselman, Marc M, Demory Beckler, Michelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Allergy/Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269990/
https://www.ncbi.nlm.nih.gov/pubmed/34277168
http://dx.doi.org/10.7759/cureus.15543
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author Elsouri, Kawther
Arboleda, Vania
Heiser, Samantha
Kesselman, Marc M
Demory Beckler, Michelle
author_facet Elsouri, Kawther
Arboleda, Vania
Heiser, Samantha
Kesselman, Marc M
Demory Beckler, Michelle
author_sort Elsouri, Kawther
collection PubMed
description Rheumatoid arthritis (RA) and celiac disease (CD) are both autoimmune diseases with increasing global prevalence. These two diseases have been connected based on similar HLA mutations, serological markers, rheumatological, and gastrointestinal manifestations. In this review, we discuss the role of the oral and gut microbiome in the development and progression of RA and CD. Here, we highlight similar microbial dysbiosis and how these alterations in composition can lead to worsening disease severity in both CD and RA. Additionally, we analyze the role of probiotics in regulating the microbiome and improving symptoms associated with RA and CD.
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spelling pubmed-82699902021-07-15 Microbiome in Rheumatoid Arthritis and Celiac Disease: A Friend or Foe Elsouri, Kawther Arboleda, Vania Heiser, Samantha Kesselman, Marc M Demory Beckler, Michelle Cureus Allergy/Immunology Rheumatoid arthritis (RA) and celiac disease (CD) are both autoimmune diseases with increasing global prevalence. These two diseases have been connected based on similar HLA mutations, serological markers, rheumatological, and gastrointestinal manifestations. In this review, we discuss the role of the oral and gut microbiome in the development and progression of RA and CD. Here, we highlight similar microbial dysbiosis and how these alterations in composition can lead to worsening disease severity in both CD and RA. Additionally, we analyze the role of probiotics in regulating the microbiome and improving symptoms associated with RA and CD. Cureus 2021-06-09 /pmc/articles/PMC8269990/ /pubmed/34277168 http://dx.doi.org/10.7759/cureus.15543 Text en Copyright © 2021, Elsouri et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Allergy/Immunology
Elsouri, Kawther
Arboleda, Vania
Heiser, Samantha
Kesselman, Marc M
Demory Beckler, Michelle
Microbiome in Rheumatoid Arthritis and Celiac Disease: A Friend or Foe
title Microbiome in Rheumatoid Arthritis and Celiac Disease: A Friend or Foe
title_full Microbiome in Rheumatoid Arthritis and Celiac Disease: A Friend or Foe
title_fullStr Microbiome in Rheumatoid Arthritis and Celiac Disease: A Friend or Foe
title_full_unstemmed Microbiome in Rheumatoid Arthritis and Celiac Disease: A Friend or Foe
title_short Microbiome in Rheumatoid Arthritis and Celiac Disease: A Friend or Foe
title_sort microbiome in rheumatoid arthritis and celiac disease: a friend or foe
topic Allergy/Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269990/
https://www.ncbi.nlm.nih.gov/pubmed/34277168
http://dx.doi.org/10.7759/cureus.15543
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