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Beam-Specific Spot Guidance and Optimization for PBS Proton Treatment of Bilateral Head and Neck Cancers

PURPOSE: A multi-field optimization (MFO) technique that uses beam-specific spot placement volumes (SPVs) and spot avoidance volumes (SAVs) is introduced for bilateral head and neck (H&N) cancers. These beam-specific volumes are used to guide the optimizer to consistently achieve optimal organ-a...

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Autores principales: Leach, Karla, Tang, Shikui, Sturgeon, Jared, Lee, Andrew K., Grover, Ryan, Sanghvi, Parag, Urbanic, James, Chang, Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Particle Therapy Co-operative Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270101/
https://www.ncbi.nlm.nih.gov/pubmed/34285935
http://dx.doi.org/10.14338/IJPT-20-00060.1
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author Leach, Karla
Tang, Shikui
Sturgeon, Jared
Lee, Andrew K.
Grover, Ryan
Sanghvi, Parag
Urbanic, James
Chang, Chang
author_facet Leach, Karla
Tang, Shikui
Sturgeon, Jared
Lee, Andrew K.
Grover, Ryan
Sanghvi, Parag
Urbanic, James
Chang, Chang
author_sort Leach, Karla
collection PubMed
description PURPOSE: A multi-field optimization (MFO) technique that uses beam-specific spot placement volumes (SPVs) and spot avoidance volumes (SAVs) is introduced for bilateral head and neck (H&N) cancers. These beam-specific volumes are used to guide the optimizer to consistently achieve optimal organ-at-risk (OAR) sparing with target coverage and plan robustness. MATERIALS AND METHODS: Implementation of this technique using a 4-beam, 5-beam, and variant 5-beam arrangement is discussed. The generation of beam-specific SPVs and SAVs derived from target and OARs are shown. The SPVs for select fields are further partitioned into optimization volumes for uniform dose distributions that resemble those of single-field optimization (SFO). A conventional MFO plan that does not use beam-specific spot placement guidance (MFOcon) and an MFO plan that uses only beam-specific SPV (MFOspv) are compared with current technique (MFOspv/sav), using both simulated scenarios and forward-calculated plans on weekly verification computed tomography (VFCT) scans. RESULTS: Dose distribution characteristics of the 4-beam, 5-beam, and variant 5-beam technique are demonstrated with discussion on OAR sparing. When comparing the MFOcon, MFOspv, and MFOspv/sav, the MFOspv/sav is shown to have superior OAR sparing in 9 of the 14 OARs examined. It also shows clinical plan robustness when evaluated by using both simulated uncertainty scenarios and forward-calculated weekly VFCTs throughout the 7-week treatment course. CONCLUSION: The MFOspv/sav technique is a systematic approach using SPVs and SAVs to guide the optimizer to consistently reach desired OAR dose values and plan robustness.
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spelling pubmed-82701012021-07-19 Beam-Specific Spot Guidance and Optimization for PBS Proton Treatment of Bilateral Head and Neck Cancers Leach, Karla Tang, Shikui Sturgeon, Jared Lee, Andrew K. Grover, Ryan Sanghvi, Parag Urbanic, James Chang, Chang Int J Part Ther Physics PURPOSE: A multi-field optimization (MFO) technique that uses beam-specific spot placement volumes (SPVs) and spot avoidance volumes (SAVs) is introduced for bilateral head and neck (H&N) cancers. These beam-specific volumes are used to guide the optimizer to consistently achieve optimal organ-at-risk (OAR) sparing with target coverage and plan robustness. MATERIALS AND METHODS: Implementation of this technique using a 4-beam, 5-beam, and variant 5-beam arrangement is discussed. The generation of beam-specific SPVs and SAVs derived from target and OARs are shown. The SPVs for select fields are further partitioned into optimization volumes for uniform dose distributions that resemble those of single-field optimization (SFO). A conventional MFO plan that does not use beam-specific spot placement guidance (MFOcon) and an MFO plan that uses only beam-specific SPV (MFOspv) are compared with current technique (MFOspv/sav), using both simulated scenarios and forward-calculated plans on weekly verification computed tomography (VFCT) scans. RESULTS: Dose distribution characteristics of the 4-beam, 5-beam, and variant 5-beam technique are demonstrated with discussion on OAR sparing. When comparing the MFOcon, MFOspv, and MFOspv/sav, the MFOspv/sav is shown to have superior OAR sparing in 9 of the 14 OARs examined. It also shows clinical plan robustness when evaluated by using both simulated uncertainty scenarios and forward-calculated weekly VFCTs throughout the 7-week treatment course. CONCLUSION: The MFOspv/sav technique is a systematic approach using SPVs and SAVs to guide the optimizer to consistently reach desired OAR dose values and plan robustness. The Particle Therapy Co-operative Group 2021-06-25 /pmc/articles/PMC8270101/ /pubmed/34285935 http://dx.doi.org/10.14338/IJPT-20-00060.1 Text en ©Copyright 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/Distributed under Creative Commons CC-BY (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Physics
Leach, Karla
Tang, Shikui
Sturgeon, Jared
Lee, Andrew K.
Grover, Ryan
Sanghvi, Parag
Urbanic, James
Chang, Chang
Beam-Specific Spot Guidance and Optimization for PBS Proton Treatment of Bilateral Head and Neck Cancers
title Beam-Specific Spot Guidance and Optimization for PBS Proton Treatment of Bilateral Head and Neck Cancers
title_full Beam-Specific Spot Guidance and Optimization for PBS Proton Treatment of Bilateral Head and Neck Cancers
title_fullStr Beam-Specific Spot Guidance and Optimization for PBS Proton Treatment of Bilateral Head and Neck Cancers
title_full_unstemmed Beam-Specific Spot Guidance and Optimization for PBS Proton Treatment of Bilateral Head and Neck Cancers
title_short Beam-Specific Spot Guidance and Optimization for PBS Proton Treatment of Bilateral Head and Neck Cancers
title_sort beam-specific spot guidance and optimization for pbs proton treatment of bilateral head and neck cancers
topic Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270101/
https://www.ncbi.nlm.nih.gov/pubmed/34285935
http://dx.doi.org/10.14338/IJPT-20-00060.1
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