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Seroprevalence of antibodies against SARS-CoV-2 virus in Northern Serbia (Vojvodina): A four consecutive sentinel population-based survey study

BACKGROUND: Monitoring changes of seroprevalence over time is important at the beginning and during of COVID-19 outbreak to anticipate its dynamics and plan an adequate public health response. METHODS: We conducted a repeated cross-sectional investigation among asymptomatic outpatient subjects and c...

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Autores principales: Ristić, Mioljub, Milosavljević, Biljana, Vapa, Slobodanka, Marković, Miloš, Petrović, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270141/
https://www.ncbi.nlm.nih.gov/pubmed/34242377
http://dx.doi.org/10.1371/journal.pone.0254516
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author Ristić, Mioljub
Milosavljević, Biljana
Vapa, Slobodanka
Marković, Miloš
Petrović, Vladimir
author_facet Ristić, Mioljub
Milosavljević, Biljana
Vapa, Slobodanka
Marković, Miloš
Petrović, Vladimir
author_sort Ristić, Mioljub
collection PubMed
description BACKGROUND: Monitoring changes of seroprevalence over time is important at the beginning and during of COVID-19 outbreak to anticipate its dynamics and plan an adequate public health response. METHODS: We conducted a repeated cross-sectional investigation among asymptomatic outpatient subjects and covered 0.1% of total population of Northern Serbia (Autonomous Province of Vojvodina). Each participant was tested for anti-SARS-CoV-2 antibodies using an immunochromatographic qualitative test (point-of-care rapid test). In the last round of survey IgG antibodies targeting the S1 subunit of the spike protein and the nucleocapsid protein of SARS-CoV-2 virus were assessed. RESULTS: During the four rounds of survey (between the end of April and the end of September), anti-SARS-CoV-2 seropositivities based on immunochromatographic test results were 2.60% (95% CI 1.80–3.63), 3.93% (95% CI 2.85–5.28), 6.11% (95% CI 4.72–7.77) and 14.60% (95% 12.51–16.89), respectively. After adjusting with results obtained from the Line immunoassay test, the estimated overall seroprevalence increased to 16.67% (95% CI 14.45–19.08) corresponding to 322,033 infections in total by the end of September 2020 in Vojvodina’s population. Throughout the course of the study, for every RT-PCR confirmed case of COVID-19, there were 39–87 additional infections in Vojvodina. No significant difference (p>0.05) in SARS-CoV-2 seropositivity regarding gender and between age subgroups was observed over the course of the survey. CONCLUSIONS: The population prevalence of SARS-CoV-2 antibodies implies much more widespread infection in Vojvodina than indicated by the number of confirmed cases. However, our results suggest that the population of Vojvodina has not reached a desirable level of protection from SARS-CoV-2 virus by the end of September 2020.
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spelling pubmed-82701412021-07-21 Seroprevalence of antibodies against SARS-CoV-2 virus in Northern Serbia (Vojvodina): A four consecutive sentinel population-based survey study Ristić, Mioljub Milosavljević, Biljana Vapa, Slobodanka Marković, Miloš Petrović, Vladimir PLoS One Research Article BACKGROUND: Monitoring changes of seroprevalence over time is important at the beginning and during of COVID-19 outbreak to anticipate its dynamics and plan an adequate public health response. METHODS: We conducted a repeated cross-sectional investigation among asymptomatic outpatient subjects and covered 0.1% of total population of Northern Serbia (Autonomous Province of Vojvodina). Each participant was tested for anti-SARS-CoV-2 antibodies using an immunochromatographic qualitative test (point-of-care rapid test). In the last round of survey IgG antibodies targeting the S1 subunit of the spike protein and the nucleocapsid protein of SARS-CoV-2 virus were assessed. RESULTS: During the four rounds of survey (between the end of April and the end of September), anti-SARS-CoV-2 seropositivities based on immunochromatographic test results were 2.60% (95% CI 1.80–3.63), 3.93% (95% CI 2.85–5.28), 6.11% (95% CI 4.72–7.77) and 14.60% (95% 12.51–16.89), respectively. After adjusting with results obtained from the Line immunoassay test, the estimated overall seroprevalence increased to 16.67% (95% CI 14.45–19.08) corresponding to 322,033 infections in total by the end of September 2020 in Vojvodina’s population. Throughout the course of the study, for every RT-PCR confirmed case of COVID-19, there were 39–87 additional infections in Vojvodina. No significant difference (p>0.05) in SARS-CoV-2 seropositivity regarding gender and between age subgroups was observed over the course of the survey. CONCLUSIONS: The population prevalence of SARS-CoV-2 antibodies implies much more widespread infection in Vojvodina than indicated by the number of confirmed cases. However, our results suggest that the population of Vojvodina has not reached a desirable level of protection from SARS-CoV-2 virus by the end of September 2020. Public Library of Science 2021-07-09 /pmc/articles/PMC8270141/ /pubmed/34242377 http://dx.doi.org/10.1371/journal.pone.0254516 Text en © 2021 Ristić et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ristić, Mioljub
Milosavljević, Biljana
Vapa, Slobodanka
Marković, Miloš
Petrović, Vladimir
Seroprevalence of antibodies against SARS-CoV-2 virus in Northern Serbia (Vojvodina): A four consecutive sentinel population-based survey study
title Seroprevalence of antibodies against SARS-CoV-2 virus in Northern Serbia (Vojvodina): A four consecutive sentinel population-based survey study
title_full Seroprevalence of antibodies against SARS-CoV-2 virus in Northern Serbia (Vojvodina): A four consecutive sentinel population-based survey study
title_fullStr Seroprevalence of antibodies against SARS-CoV-2 virus in Northern Serbia (Vojvodina): A four consecutive sentinel population-based survey study
title_full_unstemmed Seroprevalence of antibodies against SARS-CoV-2 virus in Northern Serbia (Vojvodina): A four consecutive sentinel population-based survey study
title_short Seroprevalence of antibodies against SARS-CoV-2 virus in Northern Serbia (Vojvodina): A four consecutive sentinel population-based survey study
title_sort seroprevalence of antibodies against sars-cov-2 virus in northern serbia (vojvodina): a four consecutive sentinel population-based survey study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270141/
https://www.ncbi.nlm.nih.gov/pubmed/34242377
http://dx.doi.org/10.1371/journal.pone.0254516
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