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Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology
DJ-1 was originally identified as an oncogene product while mutations of the gene encoding DJ-1/PARK7 were later associated with a recessive form of Parkinson’s disease. Its ubiquitous expression and diversity of function suggest that DJ-1 is also involved in mechanisms outside the central nervous s...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270312/ https://www.ncbi.nlm.nih.gov/pubmed/34206441 http://dx.doi.org/10.3390/molecules26133795 |
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author | Tsoporis, James N. Drosatos, Ioannis-Alexandros Gupta, Sahil Amatullah, Hajera Izhar, Shehla dos Santos, Claudia C. Salpeas, Vasileos Rigopoulos, Angelos G. Toumpoulis, Ioannis K. Triantafyllis, Andreas S. Sakadakis, Eleftharios Kavantzas, Nikolaos Marshall, John C. Rizos, Ioannis K. Parker, Thomas G. |
author_facet | Tsoporis, James N. Drosatos, Ioannis-Alexandros Gupta, Sahil Amatullah, Hajera Izhar, Shehla dos Santos, Claudia C. Salpeas, Vasileos Rigopoulos, Angelos G. Toumpoulis, Ioannis K. Triantafyllis, Andreas S. Sakadakis, Eleftharios Kavantzas, Nikolaos Marshall, John C. Rizos, Ioannis K. Parker, Thomas G. |
author_sort | Tsoporis, James N. |
collection | PubMed |
description | DJ-1 was originally identified as an oncogene product while mutations of the gene encoding DJ-1/PARK7 were later associated with a recessive form of Parkinson’s disease. Its ubiquitous expression and diversity of function suggest that DJ-1 is also involved in mechanisms outside the central nervous system. In the last decade, the contribution of DJ-1 to the protection from ischemia-reperfusion injury has been recognized and its involvement in the pathophysiology of cardiovascular disease is attracting increasing attention. This review describes the current and gaps in our knowledge of DJ-1, focusing on its role in regulating cardiovascular function. In parallel, we present original data showing an association between increased DJ-1 expression and antiapoptotic and anti-inflammatory markers following cardiac and vascular surgical procedures. Future studies should address DJ-1’s role as a plausible novel therapeutic target for cardiovascular disease. |
format | Online Article Text |
id | pubmed-8270312 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82703122021-07-10 Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology Tsoporis, James N. Drosatos, Ioannis-Alexandros Gupta, Sahil Amatullah, Hajera Izhar, Shehla dos Santos, Claudia C. Salpeas, Vasileos Rigopoulos, Angelos G. Toumpoulis, Ioannis K. Triantafyllis, Andreas S. Sakadakis, Eleftharios Kavantzas, Nikolaos Marshall, John C. Rizos, Ioannis K. Parker, Thomas G. Molecules Review DJ-1 was originally identified as an oncogene product while mutations of the gene encoding DJ-1/PARK7 were later associated with a recessive form of Parkinson’s disease. Its ubiquitous expression and diversity of function suggest that DJ-1 is also involved in mechanisms outside the central nervous system. In the last decade, the contribution of DJ-1 to the protection from ischemia-reperfusion injury has been recognized and its involvement in the pathophysiology of cardiovascular disease is attracting increasing attention. This review describes the current and gaps in our knowledge of DJ-1, focusing on its role in regulating cardiovascular function. In parallel, we present original data showing an association between increased DJ-1 expression and antiapoptotic and anti-inflammatory markers following cardiac and vascular surgical procedures. Future studies should address DJ-1’s role as a plausible novel therapeutic target for cardiovascular disease. MDPI 2021-06-22 /pmc/articles/PMC8270312/ /pubmed/34206441 http://dx.doi.org/10.3390/molecules26133795 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tsoporis, James N. Drosatos, Ioannis-Alexandros Gupta, Sahil Amatullah, Hajera Izhar, Shehla dos Santos, Claudia C. Salpeas, Vasileos Rigopoulos, Angelos G. Toumpoulis, Ioannis K. Triantafyllis, Andreas S. Sakadakis, Eleftharios Kavantzas, Nikolaos Marshall, John C. Rizos, Ioannis K. Parker, Thomas G. Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology |
title | Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology |
title_full | Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology |
title_fullStr | Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology |
title_full_unstemmed | Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology |
title_short | Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology |
title_sort | cytoprotective mechanisms of dj-1: implications in cardiac pathophysiology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270312/ https://www.ncbi.nlm.nih.gov/pubmed/34206441 http://dx.doi.org/10.3390/molecules26133795 |
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