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Zerumbone Ameliorates Neuropathic Pain Symptoms via Cannabinoid and PPAR Receptors Using In Vivo and In Silico Models

Neuropathic pain is a chronic pain condition persisting past the presence of any noxious stimulus or inflammation. Zerumbone, of the Zingiber zerumbet ginger plant, has exhibited anti-allodynic and antihyperalgesic effects in a neuropathic pain animal model, amongst other pharmacological properties....

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Autores principales: Chia, Jasmine Siew Min, Farouk, Ahmad Akira Omar, Mohamad, Tengku Azam Shah Tengku, Sulaiman, Mohd Roslan, Zakaria, Hanis, Hassan, Nurul Izzaty, Perimal, Enoch Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270339/
https://www.ncbi.nlm.nih.gov/pubmed/34202590
http://dx.doi.org/10.3390/molecules26133849
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author Chia, Jasmine Siew Min
Farouk, Ahmad Akira Omar
Mohamad, Tengku Azam Shah Tengku
Sulaiman, Mohd Roslan
Zakaria, Hanis
Hassan, Nurul Izzaty
Perimal, Enoch Kumar
author_facet Chia, Jasmine Siew Min
Farouk, Ahmad Akira Omar
Mohamad, Tengku Azam Shah Tengku
Sulaiman, Mohd Roslan
Zakaria, Hanis
Hassan, Nurul Izzaty
Perimal, Enoch Kumar
author_sort Chia, Jasmine Siew Min
collection PubMed
description Neuropathic pain is a chronic pain condition persisting past the presence of any noxious stimulus or inflammation. Zerumbone, of the Zingiber zerumbet ginger plant, has exhibited anti-allodynic and antihyperalgesic effects in a neuropathic pain animal model, amongst other pharmacological properties. This study was conducted to further elucidate the mechanisms underlying zerumbone’s antineuropathic actions. Research on therapeutic agents involving cannabinoid (CB) and peroxisome proliferator-activated receptors (PPARs) is rising. These receptor systems have shown importance in causing a synergistic effect in suppressing nociceptive processing. Behavioural responses were assessed using the von Frey filament test (mechanical allodynia) and Hargreaves plantar test (thermal hyperalgesia), in chronic constriction injury (CCI) neuropathic pain mice. Antagonists SR141716 (CB(1) receptor), SR144528 (CB(2) receptor), GW6471 (PPARα receptor) and GW9662 (PPARγ receptor) were pre-administered before the zerumbone treatment. Our findings indicated the involvement of CB(1), PPARα and PPARγ in zerumbone’s action against mechanical allodynia, whereas only CB(1) and PPARα were involved against thermal hyperalgesia. Molecular docking studies also suggest that zerumbone has a comparable and favourable binding affinity against the respective agonist on the CB and PPAR receptors studied. This finding will contribute to advance our knowledge on zerumbone and its significance in treating neuropathic pain.
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spelling pubmed-82703392021-07-10 Zerumbone Ameliorates Neuropathic Pain Symptoms via Cannabinoid and PPAR Receptors Using In Vivo and In Silico Models Chia, Jasmine Siew Min Farouk, Ahmad Akira Omar Mohamad, Tengku Azam Shah Tengku Sulaiman, Mohd Roslan Zakaria, Hanis Hassan, Nurul Izzaty Perimal, Enoch Kumar Molecules Article Neuropathic pain is a chronic pain condition persisting past the presence of any noxious stimulus or inflammation. Zerumbone, of the Zingiber zerumbet ginger plant, has exhibited anti-allodynic and antihyperalgesic effects in a neuropathic pain animal model, amongst other pharmacological properties. This study was conducted to further elucidate the mechanisms underlying zerumbone’s antineuropathic actions. Research on therapeutic agents involving cannabinoid (CB) and peroxisome proliferator-activated receptors (PPARs) is rising. These receptor systems have shown importance in causing a synergistic effect in suppressing nociceptive processing. Behavioural responses were assessed using the von Frey filament test (mechanical allodynia) and Hargreaves plantar test (thermal hyperalgesia), in chronic constriction injury (CCI) neuropathic pain mice. Antagonists SR141716 (CB(1) receptor), SR144528 (CB(2) receptor), GW6471 (PPARα receptor) and GW9662 (PPARγ receptor) were pre-administered before the zerumbone treatment. Our findings indicated the involvement of CB(1), PPARα and PPARγ in zerumbone’s action against mechanical allodynia, whereas only CB(1) and PPARα were involved against thermal hyperalgesia. Molecular docking studies also suggest that zerumbone has a comparable and favourable binding affinity against the respective agonist on the CB and PPAR receptors studied. This finding will contribute to advance our knowledge on zerumbone and its significance in treating neuropathic pain. MDPI 2021-06-24 /pmc/articles/PMC8270339/ /pubmed/34202590 http://dx.doi.org/10.3390/molecules26133849 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chia, Jasmine Siew Min
Farouk, Ahmad Akira Omar
Mohamad, Tengku Azam Shah Tengku
Sulaiman, Mohd Roslan
Zakaria, Hanis
Hassan, Nurul Izzaty
Perimal, Enoch Kumar
Zerumbone Ameliorates Neuropathic Pain Symptoms via Cannabinoid and PPAR Receptors Using In Vivo and In Silico Models
title Zerumbone Ameliorates Neuropathic Pain Symptoms via Cannabinoid and PPAR Receptors Using In Vivo and In Silico Models
title_full Zerumbone Ameliorates Neuropathic Pain Symptoms via Cannabinoid and PPAR Receptors Using In Vivo and In Silico Models
title_fullStr Zerumbone Ameliorates Neuropathic Pain Symptoms via Cannabinoid and PPAR Receptors Using In Vivo and In Silico Models
title_full_unstemmed Zerumbone Ameliorates Neuropathic Pain Symptoms via Cannabinoid and PPAR Receptors Using In Vivo and In Silico Models
title_short Zerumbone Ameliorates Neuropathic Pain Symptoms via Cannabinoid and PPAR Receptors Using In Vivo and In Silico Models
title_sort zerumbone ameliorates neuropathic pain symptoms via cannabinoid and ppar receptors using in vivo and in silico models
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270339/
https://www.ncbi.nlm.nih.gov/pubmed/34202590
http://dx.doi.org/10.3390/molecules26133849
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