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Estimating the gains of early detection of hypertension over the marginal patient

This study estimated the potential impact of early diagnosis programs on health outcomes in England. Specifically, if advising individuals to visit their family doctor due to a suspected case of mild hypertension would result in (i) an increase in the diagnosis and treatment of high blood pressure;...

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Autor principal: Rodríguez-Lesmes, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270433/
https://www.ncbi.nlm.nih.gov/pubmed/34242312
http://dx.doi.org/10.1371/journal.pone.0254260
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author Rodríguez-Lesmes, Paul
author_facet Rodríguez-Lesmes, Paul
author_sort Rodríguez-Lesmes, Paul
collection PubMed
description This study estimated the potential impact of early diagnosis programs on health outcomes in England. Specifically, if advising individuals to visit their family doctor due to a suspected case of mild hypertension would result in (i) an increase in the diagnosis and treatment of high blood pressure; (ii) an improved lifestyle reflected in objective measures such as the body-mass-index and blood pressure levels; (iii) a reduced probability of the onset of other cardiovascular diseases, such as diabetes. To address potential selection bias in screening, a feature of the English Longitudinal Study of Ageing is exploited, motivating a regression discontinuity design. If respondents’ blood pressure measurements are above a standard clinical threshold, they are advised to visit their family doctor to confirm hypertension. Two years after the protocol, there is evidence of an increase in diagnosis (5.7 pp, p-val = 0.06) and medication use (6 pp, p-val = 0.007) for treating the condition. However, four years after the protocol, the difference in diagnosis and medication disappeared (4 pp, p-val = 0.384; 3.4 pp, p-val = 0.261). Moreover, there are no differences on observed blood pressure levels (systolic 0.026 mmHg, p-val = 0.815; diastolic -0.336 mmHg, p-val = 0.765), or Body-Mass-Index ((0.771, p-val = 0.154)). There are also no differences on diagnosis of diabetes (1.7 pp, p-val = 0.343) or heart related conditions (3.6 pp, p-value = 0.161). In conclusion, the nudge produces an earlier diagnosis of around two years, but there are no perceivable gains in health outcomes after four years.
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spelling pubmed-82704332021-07-21 Estimating the gains of early detection of hypertension over the marginal patient Rodríguez-Lesmes, Paul PLoS One Research Article This study estimated the potential impact of early diagnosis programs on health outcomes in England. Specifically, if advising individuals to visit their family doctor due to a suspected case of mild hypertension would result in (i) an increase in the diagnosis and treatment of high blood pressure; (ii) an improved lifestyle reflected in objective measures such as the body-mass-index and blood pressure levels; (iii) a reduced probability of the onset of other cardiovascular diseases, such as diabetes. To address potential selection bias in screening, a feature of the English Longitudinal Study of Ageing is exploited, motivating a regression discontinuity design. If respondents’ blood pressure measurements are above a standard clinical threshold, they are advised to visit their family doctor to confirm hypertension. Two years after the protocol, there is evidence of an increase in diagnosis (5.7 pp, p-val = 0.06) and medication use (6 pp, p-val = 0.007) for treating the condition. However, four years after the protocol, the difference in diagnosis and medication disappeared (4 pp, p-val = 0.384; 3.4 pp, p-val = 0.261). Moreover, there are no differences on observed blood pressure levels (systolic 0.026 mmHg, p-val = 0.815; diastolic -0.336 mmHg, p-val = 0.765), or Body-Mass-Index ((0.771, p-val = 0.154)). There are also no differences on diagnosis of diabetes (1.7 pp, p-val = 0.343) or heart related conditions (3.6 pp, p-value = 0.161). In conclusion, the nudge produces an earlier diagnosis of around two years, but there are no perceivable gains in health outcomes after four years. Public Library of Science 2021-07-09 /pmc/articles/PMC8270433/ /pubmed/34242312 http://dx.doi.org/10.1371/journal.pone.0254260 Text en © 2021 Paul Rodríguez-Lesmes https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Rodríguez-Lesmes, Paul
Estimating the gains of early detection of hypertension over the marginal patient
title Estimating the gains of early detection of hypertension over the marginal patient
title_full Estimating the gains of early detection of hypertension over the marginal patient
title_fullStr Estimating the gains of early detection of hypertension over the marginal patient
title_full_unstemmed Estimating the gains of early detection of hypertension over the marginal patient
title_short Estimating the gains of early detection of hypertension over the marginal patient
title_sort estimating the gains of early detection of hypertension over the marginal patient
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270433/
https://www.ncbi.nlm.nih.gov/pubmed/34242312
http://dx.doi.org/10.1371/journal.pone.0254260
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