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COVID-19 incidence and mortality in non-dialysis chronic kidney disease patients

Many studies reported a higher risk of COVID-19 disease among patients on dialysis or with kidney transplantation, and the poor outcome of COVID-19 in these patients. Patients in conservative management for chronic kidney disease (CKD) have received attention only recently, therefore less is known a...

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Autores principales: Gibertoni, Dino, Reno, Chiara, Rucci, Paola, Fantini, Maria Pia, Buscaroli, Andrea, Mosconi, Giovanni, Rigotti, Angelo, Giudicissi, Antonio, Mambelli, Emanuele, Righini, Matteo, Zambianchi, Loretta, Santoro, Antonio, Bravi, Francesca, Altini, Mattia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270438/
https://www.ncbi.nlm.nih.gov/pubmed/34242368
http://dx.doi.org/10.1371/journal.pone.0254525
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author Gibertoni, Dino
Reno, Chiara
Rucci, Paola
Fantini, Maria Pia
Buscaroli, Andrea
Mosconi, Giovanni
Rigotti, Angelo
Giudicissi, Antonio
Mambelli, Emanuele
Righini, Matteo
Zambianchi, Loretta
Santoro, Antonio
Bravi, Francesca
Altini, Mattia
author_facet Gibertoni, Dino
Reno, Chiara
Rucci, Paola
Fantini, Maria Pia
Buscaroli, Andrea
Mosconi, Giovanni
Rigotti, Angelo
Giudicissi, Antonio
Mambelli, Emanuele
Righini, Matteo
Zambianchi, Loretta
Santoro, Antonio
Bravi, Francesca
Altini, Mattia
author_sort Gibertoni, Dino
collection PubMed
description Many studies reported a higher risk of COVID-19 disease among patients on dialysis or with kidney transplantation, and the poor outcome of COVID-19 in these patients. Patients in conservative management for chronic kidney disease (CKD) have received attention only recently, therefore less is known about how COVID-19 affects this population. The aim of this study was to provide evidence on COVID-19 incidence and mortality in CKD patients followed up in an integrated healthcare program and in the population living in the same catchment area. The study population included CKD patients recruited in the Emilia-Romagna Prevention of Progressive Renal Insufficiency (PIRP) project, followed up in the 4 nephrology units (Ravenna, Forlì, Cesena and Rimini) of the Romagna Local Health Authority (Italy) and alive at 1.01.2020. We estimated the incidence of COVID-19, its related mortality and the excess mortality within this PIRP cohort as of 31.07.2020. COVID-19 incidence in CKD patients was 4.09% (193/4,716 patients), while in the general population it was 0.46% (5,195/1,125,574). The crude mortality rate among CKD patients with COVID-19 was 44.6% (86/193), compared to 4.7% (215/4,523) in CKD patients without COVID-19. The excess mortality of March-April 2020 was +69.8% than the average mortality of March-April 2015–19 in the PIRP cohort. In a cohort mostly including regularly followed up CKD patients, the incidence of COVID-19 among CKD patients was strongly related to the spread of the infection in the community, while its lethality is associated with the underlying kidney condition and comorbidities. COVID-19 related mortality was about ten times higher than that of CKD patients without COVID. For this reason, it is urgent to offer a direct protection to CKD patients by prioritizing their vaccination.
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spelling pubmed-82704382021-07-21 COVID-19 incidence and mortality in non-dialysis chronic kidney disease patients Gibertoni, Dino Reno, Chiara Rucci, Paola Fantini, Maria Pia Buscaroli, Andrea Mosconi, Giovanni Rigotti, Angelo Giudicissi, Antonio Mambelli, Emanuele Righini, Matteo Zambianchi, Loretta Santoro, Antonio Bravi, Francesca Altini, Mattia PLoS One Research Article Many studies reported a higher risk of COVID-19 disease among patients on dialysis or with kidney transplantation, and the poor outcome of COVID-19 in these patients. Patients in conservative management for chronic kidney disease (CKD) have received attention only recently, therefore less is known about how COVID-19 affects this population. The aim of this study was to provide evidence on COVID-19 incidence and mortality in CKD patients followed up in an integrated healthcare program and in the population living in the same catchment area. The study population included CKD patients recruited in the Emilia-Romagna Prevention of Progressive Renal Insufficiency (PIRP) project, followed up in the 4 nephrology units (Ravenna, Forlì, Cesena and Rimini) of the Romagna Local Health Authority (Italy) and alive at 1.01.2020. We estimated the incidence of COVID-19, its related mortality and the excess mortality within this PIRP cohort as of 31.07.2020. COVID-19 incidence in CKD patients was 4.09% (193/4,716 patients), while in the general population it was 0.46% (5,195/1,125,574). The crude mortality rate among CKD patients with COVID-19 was 44.6% (86/193), compared to 4.7% (215/4,523) in CKD patients without COVID-19. The excess mortality of March-April 2020 was +69.8% than the average mortality of March-April 2015–19 in the PIRP cohort. In a cohort mostly including regularly followed up CKD patients, the incidence of COVID-19 among CKD patients was strongly related to the spread of the infection in the community, while its lethality is associated with the underlying kidney condition and comorbidities. COVID-19 related mortality was about ten times higher than that of CKD patients without COVID. For this reason, it is urgent to offer a direct protection to CKD patients by prioritizing their vaccination. Public Library of Science 2021-07-09 /pmc/articles/PMC8270438/ /pubmed/34242368 http://dx.doi.org/10.1371/journal.pone.0254525 Text en © 2021 Gibertoni et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Gibertoni, Dino
Reno, Chiara
Rucci, Paola
Fantini, Maria Pia
Buscaroli, Andrea
Mosconi, Giovanni
Rigotti, Angelo
Giudicissi, Antonio
Mambelli, Emanuele
Righini, Matteo
Zambianchi, Loretta
Santoro, Antonio
Bravi, Francesca
Altini, Mattia
COVID-19 incidence and mortality in non-dialysis chronic kidney disease patients
title COVID-19 incidence and mortality in non-dialysis chronic kidney disease patients
title_full COVID-19 incidence and mortality in non-dialysis chronic kidney disease patients
title_fullStr COVID-19 incidence and mortality in non-dialysis chronic kidney disease patients
title_full_unstemmed COVID-19 incidence and mortality in non-dialysis chronic kidney disease patients
title_short COVID-19 incidence and mortality in non-dialysis chronic kidney disease patients
title_sort covid-19 incidence and mortality in non-dialysis chronic kidney disease patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270438/
https://www.ncbi.nlm.nih.gov/pubmed/34242368
http://dx.doi.org/10.1371/journal.pone.0254525
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