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COVID-19 incidence and mortality in non-dialysis chronic kidney disease patients
Many studies reported a higher risk of COVID-19 disease among patients on dialysis or with kidney transplantation, and the poor outcome of COVID-19 in these patients. Patients in conservative management for chronic kidney disease (CKD) have received attention only recently, therefore less is known a...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270438/ https://www.ncbi.nlm.nih.gov/pubmed/34242368 http://dx.doi.org/10.1371/journal.pone.0254525 |
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author | Gibertoni, Dino Reno, Chiara Rucci, Paola Fantini, Maria Pia Buscaroli, Andrea Mosconi, Giovanni Rigotti, Angelo Giudicissi, Antonio Mambelli, Emanuele Righini, Matteo Zambianchi, Loretta Santoro, Antonio Bravi, Francesca Altini, Mattia |
author_facet | Gibertoni, Dino Reno, Chiara Rucci, Paola Fantini, Maria Pia Buscaroli, Andrea Mosconi, Giovanni Rigotti, Angelo Giudicissi, Antonio Mambelli, Emanuele Righini, Matteo Zambianchi, Loretta Santoro, Antonio Bravi, Francesca Altini, Mattia |
author_sort | Gibertoni, Dino |
collection | PubMed |
description | Many studies reported a higher risk of COVID-19 disease among patients on dialysis or with kidney transplantation, and the poor outcome of COVID-19 in these patients. Patients in conservative management for chronic kidney disease (CKD) have received attention only recently, therefore less is known about how COVID-19 affects this population. The aim of this study was to provide evidence on COVID-19 incidence and mortality in CKD patients followed up in an integrated healthcare program and in the population living in the same catchment area. The study population included CKD patients recruited in the Emilia-Romagna Prevention of Progressive Renal Insufficiency (PIRP) project, followed up in the 4 nephrology units (Ravenna, Forlì, Cesena and Rimini) of the Romagna Local Health Authority (Italy) and alive at 1.01.2020. We estimated the incidence of COVID-19, its related mortality and the excess mortality within this PIRP cohort as of 31.07.2020. COVID-19 incidence in CKD patients was 4.09% (193/4,716 patients), while in the general population it was 0.46% (5,195/1,125,574). The crude mortality rate among CKD patients with COVID-19 was 44.6% (86/193), compared to 4.7% (215/4,523) in CKD patients without COVID-19. The excess mortality of March-April 2020 was +69.8% than the average mortality of March-April 2015–19 in the PIRP cohort. In a cohort mostly including regularly followed up CKD patients, the incidence of COVID-19 among CKD patients was strongly related to the spread of the infection in the community, while its lethality is associated with the underlying kidney condition and comorbidities. COVID-19 related mortality was about ten times higher than that of CKD patients without COVID. For this reason, it is urgent to offer a direct protection to CKD patients by prioritizing their vaccination. |
format | Online Article Text |
id | pubmed-8270438 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-82704382021-07-21 COVID-19 incidence and mortality in non-dialysis chronic kidney disease patients Gibertoni, Dino Reno, Chiara Rucci, Paola Fantini, Maria Pia Buscaroli, Andrea Mosconi, Giovanni Rigotti, Angelo Giudicissi, Antonio Mambelli, Emanuele Righini, Matteo Zambianchi, Loretta Santoro, Antonio Bravi, Francesca Altini, Mattia PLoS One Research Article Many studies reported a higher risk of COVID-19 disease among patients on dialysis or with kidney transplantation, and the poor outcome of COVID-19 in these patients. Patients in conservative management for chronic kidney disease (CKD) have received attention only recently, therefore less is known about how COVID-19 affects this population. The aim of this study was to provide evidence on COVID-19 incidence and mortality in CKD patients followed up in an integrated healthcare program and in the population living in the same catchment area. The study population included CKD patients recruited in the Emilia-Romagna Prevention of Progressive Renal Insufficiency (PIRP) project, followed up in the 4 nephrology units (Ravenna, Forlì, Cesena and Rimini) of the Romagna Local Health Authority (Italy) and alive at 1.01.2020. We estimated the incidence of COVID-19, its related mortality and the excess mortality within this PIRP cohort as of 31.07.2020. COVID-19 incidence in CKD patients was 4.09% (193/4,716 patients), while in the general population it was 0.46% (5,195/1,125,574). The crude mortality rate among CKD patients with COVID-19 was 44.6% (86/193), compared to 4.7% (215/4,523) in CKD patients without COVID-19. The excess mortality of March-April 2020 was +69.8% than the average mortality of March-April 2015–19 in the PIRP cohort. In a cohort mostly including regularly followed up CKD patients, the incidence of COVID-19 among CKD patients was strongly related to the spread of the infection in the community, while its lethality is associated with the underlying kidney condition and comorbidities. COVID-19 related mortality was about ten times higher than that of CKD patients without COVID. For this reason, it is urgent to offer a direct protection to CKD patients by prioritizing their vaccination. Public Library of Science 2021-07-09 /pmc/articles/PMC8270438/ /pubmed/34242368 http://dx.doi.org/10.1371/journal.pone.0254525 Text en © 2021 Gibertoni et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Gibertoni, Dino Reno, Chiara Rucci, Paola Fantini, Maria Pia Buscaroli, Andrea Mosconi, Giovanni Rigotti, Angelo Giudicissi, Antonio Mambelli, Emanuele Righini, Matteo Zambianchi, Loretta Santoro, Antonio Bravi, Francesca Altini, Mattia COVID-19 incidence and mortality in non-dialysis chronic kidney disease patients |
title | COVID-19 incidence and mortality in non-dialysis chronic kidney disease patients |
title_full | COVID-19 incidence and mortality in non-dialysis chronic kidney disease patients |
title_fullStr | COVID-19 incidence and mortality in non-dialysis chronic kidney disease patients |
title_full_unstemmed | COVID-19 incidence and mortality in non-dialysis chronic kidney disease patients |
title_short | COVID-19 incidence and mortality in non-dialysis chronic kidney disease patients |
title_sort | covid-19 incidence and mortality in non-dialysis chronic kidney disease patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270438/ https://www.ncbi.nlm.nih.gov/pubmed/34242368 http://dx.doi.org/10.1371/journal.pone.0254525 |
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