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VAL genes regulate vegetative phase change via miR156-dependent and independent mechanisms

How organisms control when to transition between different stages of development is a key question in biology. In plants, epigenetic silencing by Polycomb repressive complex 1 (PRC1) and PRC2 plays a crucial role in promoting developmental transitions, including from juvenile-to-adult phases of vege...

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Autores principales: Fouracre, Jim P., He, Jia, Chen, Victoria J., Sidoli, Simone, Poethig, R. Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270478/
https://www.ncbi.nlm.nih.gov/pubmed/34181637
http://dx.doi.org/10.1371/journal.pgen.1009626
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author Fouracre, Jim P.
He, Jia
Chen, Victoria J.
Sidoli, Simone
Poethig, R. Scott
author_facet Fouracre, Jim P.
He, Jia
Chen, Victoria J.
Sidoli, Simone
Poethig, R. Scott
author_sort Fouracre, Jim P.
collection PubMed
description How organisms control when to transition between different stages of development is a key question in biology. In plants, epigenetic silencing by Polycomb repressive complex 1 (PRC1) and PRC2 plays a crucial role in promoting developmental transitions, including from juvenile-to-adult phases of vegetative growth. PRC1/2 are known to repress the master regulator of vegetative phase change, miR156, leading to the transition to adult growth, but how this process is regulated temporally is unknown. Here we investigate whether transcription factors in the VIVIPAROUS/ABI3-LIKE (VAL) gene family provide the temporal signal for the epigenetic repression of miR156. Exploiting a novel val1 allele, we found that VAL1 and VAL2 redundantly regulate vegetative phase change by controlling the overall level, rather than temporal dynamics, of miR156 expression. Furthermore, we discovered that VAL1 and VAL2 also act independently of miR156 to control this important developmental transition. In combination, our results highlight the complexity of temporal regulation in plants.
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spelling pubmed-82704782021-07-21 VAL genes regulate vegetative phase change via miR156-dependent and independent mechanisms Fouracre, Jim P. He, Jia Chen, Victoria J. Sidoli, Simone Poethig, R. Scott PLoS Genet Research Article How organisms control when to transition between different stages of development is a key question in biology. In plants, epigenetic silencing by Polycomb repressive complex 1 (PRC1) and PRC2 plays a crucial role in promoting developmental transitions, including from juvenile-to-adult phases of vegetative growth. PRC1/2 are known to repress the master regulator of vegetative phase change, miR156, leading to the transition to adult growth, but how this process is regulated temporally is unknown. Here we investigate whether transcription factors in the VIVIPAROUS/ABI3-LIKE (VAL) gene family provide the temporal signal for the epigenetic repression of miR156. Exploiting a novel val1 allele, we found that VAL1 and VAL2 redundantly regulate vegetative phase change by controlling the overall level, rather than temporal dynamics, of miR156 expression. Furthermore, we discovered that VAL1 and VAL2 also act independently of miR156 to control this important developmental transition. In combination, our results highlight the complexity of temporal regulation in plants. Public Library of Science 2021-06-28 /pmc/articles/PMC8270478/ /pubmed/34181637 http://dx.doi.org/10.1371/journal.pgen.1009626 Text en © 2021 Fouracre et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Fouracre, Jim P.
He, Jia
Chen, Victoria J.
Sidoli, Simone
Poethig, R. Scott
VAL genes regulate vegetative phase change via miR156-dependent and independent mechanisms
title VAL genes regulate vegetative phase change via miR156-dependent and independent mechanisms
title_full VAL genes regulate vegetative phase change via miR156-dependent and independent mechanisms
title_fullStr VAL genes regulate vegetative phase change via miR156-dependent and independent mechanisms
title_full_unstemmed VAL genes regulate vegetative phase change via miR156-dependent and independent mechanisms
title_short VAL genes regulate vegetative phase change via miR156-dependent and independent mechanisms
title_sort val genes regulate vegetative phase change via mir156-dependent and independent mechanisms
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270478/
https://www.ncbi.nlm.nih.gov/pubmed/34181637
http://dx.doi.org/10.1371/journal.pgen.1009626
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