WPBs: making a mark and leaving a trail

In this issue of Blood, Holthenrich et al used a proximity labeling approach to pull, from out of the crowded intracellular milieu, proteins that specifically interact with Weibel-Palade bodies (WPBs). From the resulting catalog of proteins, the authors identified Munc13-2 as a novel WPB-associated...

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Detalles Bibliográficos
Autores principales: Carter, Tom, Bierings, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2019
Materias:
Vascular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270482/
https://www.ncbi.nlm.nih.gov/pubmed/31537537
http://dx.doi.org/10.1182/blood.2019002322
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author Carter, Tom
Bierings, Ruben
author_facet Carter, Tom
Bierings, Ruben
author_sort Carter, Tom
collection PubMed
description In this issue of Blood, Holthenrich et al used a proximity labeling approach to pull, from out of the crowded intracellular milieu, proteins that specifically interact with Weibel-Palade bodies (WPBs). From the resulting catalog of proteins, the authors identified Munc13-2 as a novel WPB-associated SNARE-interacting protein that positively regulates hormone-evoked WPB exocytosis.(1)
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spelling pubmed-82704822021-07-20 WPBs: making a mark and leaving a trail Carter, Tom Bierings, Ruben Blood Vascular Biology In this issue of Blood, Holthenrich et al used a proximity labeling approach to pull, from out of the crowded intracellular milieu, proteins that specifically interact with Weibel-Palade bodies (WPBs). From the resulting catalog of proteins, the authors identified Munc13-2 as a novel WPB-associated SNARE-interacting protein that positively regulates hormone-evoked WPB exocytosis.(1) American Society of Hematology 2019-09-19 2020-12-14 /pmc/articles/PMC8270482/ /pubmed/31537537 http://dx.doi.org/10.1182/blood.2019002322 Text en Copyright © 2019 American Society of Hematology. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Vascular Biology
Carter, Tom
Bierings, Ruben
WPBs: making a mark and leaving a trail
title WPBs: making a mark and leaving a trail
title_full WPBs: making a mark and leaving a trail
title_fullStr WPBs: making a mark and leaving a trail
title_full_unstemmed WPBs: making a mark and leaving a trail
title_short WPBs: making a mark and leaving a trail
title_sort wpbs: making a mark and leaving a trail
topic Vascular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270482/
https://www.ncbi.nlm.nih.gov/pubmed/31537537
http://dx.doi.org/10.1182/blood.2019002322
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