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Mechanical forces regulate endothelial-to-mesenchymal transition and atherosclerosis via an Alk5-Shc mechanotransduction pathway
The response of endothelial cells to mechanical forces is a critical determinant of vascular health. Vascular pathologies, such as atherosclerosis, characterized by abnormal mechanical forces are frequently accompanied by endothelial-to-mesenchymal transition (EndMT). However, how forces affect the...
Autores principales: | Mehta, Vedanta, Pang, Kar-Lai, Givens, Christopher S., Chen, Zhongming, Huang, Jianhua, Sweet, Daniel T., Jo, Hanjoong, Reader, John S., Tzima, Ellie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270486/ https://www.ncbi.nlm.nih.gov/pubmed/34244146 http://dx.doi.org/10.1126/sciadv.abg5060 |
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