The fluid shear stress sensor TRPM7 regulates tumor cell intravasation

Tumor cell intravasation preferentially occurs in regions of low fluid shear because high shear is detrimental to tumor cells. Here, we describe a molecular mechanism by which cells avoid high shear during intravasation. The transition from migration to intravasation was modeled using a microfluidic...

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Detalles Bibliográficos
Autores principales: Yankaskas, Christopher L., Bera, Kaustav, Stoletov, Konstantin, Serra, Selma A., Carrillo-Garcia, Julia, Tuntithavornwat, Soontorn, Mistriotis, Panagiotis, Lewis, John D., Valverde, Miguel A., Konstantopoulos, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270498/
https://www.ncbi.nlm.nih.gov/pubmed/34244134
http://dx.doi.org/10.1126/sciadv.abh3457

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